An insulin-like growth factor 1 receptor inhibitor induces CYP3A4 expression through a pregnane X receptor-independent, noncanonical constitutive androstane receptor- related mechanism

Journal of Pharmacology and Experimental Therapeutics

Volumn 340, Issue 3, 2012, Pages 688-697

  Li, Linhao ^a   Sinz, Michael W ^b   Zimmermann, Kurt ^b   Wang, Hongbing ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [1 [2 [4 [[2 (4 CHLORO 1H PYRAZOL 1 YL)ETHYL]AMINO] 2 OXO 1,2 DIHYDROPYRIDIN 3 YL] 4 METHYL 1H BENZO[D]IMIDAZOL 6 YL]PIPERIDIN 4 YL]PIPERAZINE 1 CARBOXYLATE; BMS 665351; CONSTITUTIVE ANDROSTANE RECEPTOR; CYCLOHEXIMIDE; CYTOCHROME P450 3A4; DACTINOMYCIN; MESSENGER RNA; PREGNANE X RECEPTOR; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; CELL ASSAY; CELL NUCLEUS; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOCHROME P450 3A4 GENE; CYTOPLASM; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME LOCALIZATION; ENZYME MECHANISM; ENZYME STRUCTURE; GENE; HUMAN; HUMAN CELL; LIVER CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; WESTERN BLOTTING;

ACTIVE TRANSPORT, CELL NUCLEUS; BENZIMIDAZOLES; CYCLOHEXIMIDE; CYTOCHROME P-450 CYP3A; DACTINOMYCIN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEP G2 CELLS; HEPATOCYTES; HUMANS; PIPERAZINES; RECEPTOR, IGF TYPE 1; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RNA, MESSENGER;

EID: 84863122056     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.188854     Document Type: Article

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