Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo

Biochemical Journal

Volumn 442, Issue 1, 2012, Pages 161-169

  Smith, Greg C ^a   Ong, Wee Kiat ^b   Rewcastle, Gordon W ^a,c   Kendall, Jackie D ^a,c   Han, Weiping ^b   Shepherd, Peter R ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b AGENCY FOR SCIENCE   (Singapore)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Glucose metabolism; Insulin; Mammalian target of rapamycin (mTOR); Phosphoinositide 3 kinase (PI3K); Phosphoinositide 3 kinase catalytic polypeptide (PIK3CA)

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 2 (2 DIFLUOROMETHYLBENZIMIDAZOL 1 YL) 4,6 DIMORPHOLINO 1,3,5 TRIAZINE; 2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; 2 (6 AMINO 9 PURINYLMETHYL) 5 METHYL 3 (2 METHYLPHENYL) 3H QUINAZOLIN 4 ONE; 5 [5 (4 FLUORO 2 HYDROXYPHENYL)FURFURYLIDENE] 2,4 THIAZOLIDINEDIONE; 9 (1 ANILINOETHYL) 7 METHYL 2 MORPHOLINOPYRIDO[1,2 A]PYRIMIDIN 4 ONE; GLUCOSE; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PHENMETRAZINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PIK 75; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASAL METABOLIC RATE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; ENZYME REGULATION; FEMALE; FLUID INTAKE; FOOD INTAKE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; IMPAIRED GLUCOSE TOLERANCE; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; MALE; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PHARMACOLOGICAL BLOCKING; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; EATING; ENZYME INHIBITORS; FURANS; GLUCOSE; HYDRAZONES; IMIDAZOLES; ISOENZYMES; MALE; MICE; MOTOR ACTIVITY; PHOSPHATIDYLINOSITOL 3-KINASES; PYRIDINES; PYRIMIDINES; QUINOLINES; SULFONAMIDES; TOR SERINE-THREONINE KINASES;

ANIMALIA; MAMMALIA; MUS;

EID: 84863080820     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20111913     Document Type: Article

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