Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking

Journal of Biological Chemistry

Volumn 287, Issue 6, 2012, Pages 3963-3975

  Woo, Michael G ^a,b   Xue, Kai ^a,b,c   Liu, Jiayin ^c   McBride, Heidi ^a   Tsang, Benjamin K ^a,b,d  

^a UNIVERSITY OF OTTAWA   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c NANJING MEDICAL UNIVERSITY   (China)

^d Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

26 S PROTEASOME; ANTI-APOPTOTIC PROTEIN; CALPAINS; CASPASE-3; CASPASES; CHEMORESISTANCE; CHEMOSENSITIVITY; CISPLATIN; CLEAVAGE SITES; CONTRIBUTING FACTOR; CYTOPLASMIC PROTEINS; DOWN-REGULATION; IN-VITRO; IONOMYCIN; MOLECULAR MECHANISM; OVARIAN CANCER CELLS; OVARIAN CANCERS; POST-TRANSLATIONAL PROCESSING; PRO-APOPTOTIC FUNCTION; PROTEASOMAL DEGRADATION; SIGNALING PATHWAYS; SUB-CELLULAR; SUBCELLULAR LOCALIZATIONS;

CALCIUM; PLATINUM COMPOUNDS; PROTEINS;

CELL DEATH;

26S PROTEASOME; CALCIUM ION; CALPAIN; CASPASE; CISPLATIN; IONOMYCIN; PROTEASOME; PROTEIN KINASE B; PROTEIN P53; PROTEIN PARC; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CALCIUM SIGNALING; CANCER CELL CULTURE; CANCER RESISTANCE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG SENSITIVITY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR TRANSPORT; MITOCHONDRION; OVARY CANCER; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN PROCESSING; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CALCIUM; CALCIUM IONOPHORES; CALPAIN; CARRIER PROTEINS; CASPASE 3; CELL LINE, TUMOR; CISPLATIN; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IONOMYCIN; OVARIAN NEOPLASMS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84863066878     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.314765     Document Type: Article

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