Sch9 partially mediates TORC1 signaling to control ribosomal RNA synthesis

Cell Cycle

Volumn 8, Issue 24, 2009, Pages 4085-4090

  Wei, Yuehua ^a   Zheng, X F Steven ^b  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

Maf1; Nucleolus; RNA polymerase III; Sch9; TOR (target of rapamycin)

Indexed keywords

DNA DIRECTED DNA POLYMERASE ALPHA; DNA DIRECTED DNA POLYMERASE BETA; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHOTRANSFERASE; PROTEIN MAF1; PROTEIN SCH9; RAPAMYCIN; REPRESSOR PROTEIN; RIBOSOME RNA; TARGET OF RAPAMYCIN COMPLEX 1; TRANSFER RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL GROWTH; CELLULAR DISTRIBUTION; CYTOPLASM; ENZYME PHOSPHORYLATION; NONHUMAN; NUCLEOCYTOPLASMIC TRANSPORT; NUCLEOLUS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RIBOSOME; RNA SYNTHESIS; RNA TRANSCRIPTION;

EID: 74849135206     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.24.10170     Document Type: Article

References (31)

1. Keith CT, Schreiber SL. PIK-related kinases: DNA repair, recombination and cell cycle checkpoints. Science 1995; 270:50-1.
2. Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo J, Bonenfant D, et al. Two TOR Complexes, Only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 2002; 10:457-68.
3. Zheng XF, Florentino D, Chen J, Crabtree GR, Schreiber SL. TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin. Cell 1995; 82:121-30.
4. Wullschleger S, Loewith R, Hall MN. TOR Signaling in growth and metabolism. Cell 2006; 124:471-84.
5. Tsang C, Zheng X. TOR-in(g) the nucleus. Cell Cycle 2007; 6:25-9.
6. Warner JR. The economics of ribosome biosynthesis in yeast. Trends Biochem Sci 1999; 24:437-40.
7. Moss T, Stefanovsky VY. At the center of eukaryotic life. Cell 2002; 109:545-8.
8. White R. RNA polymerases I and III, growth control and cancer. Nat Rev Mol Cell Biol 2005; 6:69-78.
9. Johnson DL, Johnson SAS. Cell Biology: RNA metabolism and oncogenesis. Science 2008; 320:461-2.
10. 0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway. Mol Cell Biol 1998; 18:4463-70.
11. Powers T, Walter P. Regulation of ribosmome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae. Mol Biol Cell 1999; 10:987-1000.
12. Li H, Tsang C, Watkins M, Bertram P, Zheng X. Nutrient regulates Tor1 nuclear localization and association with rDNA promoter. Nature 2006; 442:1058-61.
13. Drenan RM, Liu X, Bertram PG, Zheng XFS. FKBP12-Rapamycin-associated protein or mammalian target of rapamycin (FRAP/mTOR) localization in the Endoplasmic reticulum and the Golgi apparatus. J Biol Chem 2004; 279:772-8.
14. Zhang X, Shu L, Hosoi H, Murti KG, Houghton PJ. Predominant nuclear localization of mammalian target of rapamycin in normal and malignant cells in culture. J Biol Chem 2002; 277:28127-381.
15. Wei Y, Tsang CK, Zheng XF. Mechanisms of regulation of RNA polymerase III-dependent transcription by TORC1. EMBO J 2009; 28:2220-30.
16. Upadhya R, Lee J, Willis I. Maf1 is an essential mediator of diverse signals that repress RNA polymerase III transcription. Mol Cell 2002; 10:1489-94.
17. Roberts D, Wilson B, Huff J, Stewart A, Cairns B. Dephosphorylation and genome-wide association of Maf1 with Pol III-transcribed genes during repression. Mol Cell 2006; 22:633-44.
18. Oficjalska-Pham D, Harismendy O, Smagowicz W, Gonzalez de Pered A, Boguta M, Sentenac A, et al. General repression of RNA polymerase III transcription is triggered by protein phosphatase type 2A-mediated dephosphorylation of Maf1. Mol Cell 2006; 22:623-32.
19. Moir RD, Lee J, Haeusler RA, Desai N, Engelke DR, Willis IM. Protein kinase A regulates RNA polymerase III transcription through the nuclear localization of Maf1. Proc Natl Acad Sci USA 2006; 103:15044-9.
20. Towpik J, Graczyk D, Gajda A, Lefebvre O, Boguta M. Derepression of RNA polymerase III transcription by phosphorylation and nuclear export of its negative regulator, Maf1. J Biol Chem 2008; 283:17168-74.
21. Jorgensen P, Rupes I, Sharom JR, Schneper L, Broach JR, Tyers M. A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size. Genes Dev 2004; 18:2491-505.
22. Urban J, Soulard A, Huber A, Lippman S, Mukhopadhyay D, Deloche O, et al. Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Mol Cell 2007; 26:663-74.
23. Lee J, Moir RD, Willis IM. Regulation of RNA polymerase III transcription involves SCH9-dependent and SCH9-independent branches of the target of rapamycin (TOR) pathway. J Biol Chem 2009; 284:12604-8.
24. Huber A, Bodenmiller B, Uotila A, Stahl M, Wanka S, Gerrits B, et al. Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis. Genes Dev 2009; 23:1929-43.
25. Morano KA, Thiele DJ. The Sch9 protein kinase regulates Hsp90 chaperone complex signal transduction activity in vivo. EMBO J 1999; 18:5953-62.
26. Pluta K, Lefebvre O, Martin NC, Smagowicz WJ, Stanford DR, Ellis SR, et al. Maf1p, a negative effector of RNA polymerase III in Saccharomyces cerevisiae. Mol Cell Biol 2001; 21:5031-40.
27. Ciesla M, Towpik J, Graczyk D, Oficjalska-Pham D, Harismendy O, Suleau A, et al. Maf1 is involved in coupling carbon metabolism to RNA Polymerase III transcription. Mol Cell Biol 2007; 27:7693-702.
28. Chan TF, Carvalho J, Riles L, Zheng XFS. A chemical genomics approach toward understanding the global functions of TOR. Proc Natl Acad Sci USA 2000; 97:13227-32.
29. Mayer C, Zhao J, Yuan X, Grummt I. mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability. Genes Dev 2004; 18:423-34.
30. Claypool JA, French SL, Johzuka K, Eliason K, Vu L, Dodd JA, et al. Tor pathway regulates Rrn3p-dependent recruitment of Yeast RNA polymerase I to the promoter but does not participate in alteration of the number of active genes. Mol Biol Cell 2004; 15:946-56.
31. Fabrizio P, Pozza F, Pletcher SD, Gendron CM, Longo VD. Regulation of longevity and stress resistance by Sch9 in yeast. Science 2001; 292:288-90.