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Volumn 42, Issue 3, 2012, Pages 266-277

Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues

Author keywords

Glucuronidation; UDP glucuronosyltransferase; UGT

Indexed keywords

BETA ACTIN; GLUCURONOSYLTRANSFERASE; MESSENGER RNA; RNA; RNA 18S; URIDINE DIPHOSPHATE GLUCURONIC ACID;

EID: 84863042741     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2011.618954     Document Type: Article
Times cited : (179)

References (38)
  • 2
    • 0024272881 scopus 로고
    • The inadequacy of perinatal glucuronidation: Immunoblot analysis of the developmental expression of individual UDP-glucuronosyltransferase isoenzymes in rat and human liver microsomes
    • Coughtrie MW, Burchell B, Leakey JE, Hume R. (1988). The inadequacy of perinatal glucuronidation: Immunoblot analysis of the developmental expression of individual UDPglucuronosyltransferase isoenzymes in rat and human liver microsomes. Mol Pharmacol 34:729-735. (Pubitemid 19014393)
    • (1988) Molecular Pharmacology , vol.34 , Issue.6 , pp. 729-735
    • Coughtrie, M.W.H.1    Burchell, B.2    Leakey, J.E.A.3    Hume, R.4
  • 4
    • 0042858542 scopus 로고    scopus 로고
    • Evaluation of 3′-azido-3′-deoxythymidine, morphine, and codeine as probe substrates for udp-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: Specificity and influence of the UGT2B7*2 polymorphism
    • DOI 10.1124/dmd.31.9.1125
    • Court MH, Krishnaswamy S, Hao Q, Duan SX, Patten CJ, Von Moltke LL, Greenblatt DJ. (2003). Evaluation of 3?-azido-3?-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: Specificity and influence of the UGT2B72 polymorphism. Drug Metab Dispos 31:1125-1133. (Pubitemid 37048284)
    • (2003) Drug Metabolism and Disposition , vol.31 , Issue.9 , pp. 1125-1133
    • Court, M.H.1    Krishnaswamy, S.2    Hao, Q.3    Duan, S.X.4    Patten, C.J.5    Von Moltke, L.L.6    Greenblatt, D.J.7
  • 5
    • 30144436526 scopus 로고    scopus 로고
    • Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases
    • DOI 10.1016/S0076-6879(05)00007-8, PII S0076687905000078, 7, Phase II Conjugation Enzymes and Transport Systems
    • Court MH. (2005). Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases. Meth Enzymol 400:104-116. (Pubitemid 43052418)
    • (2005) Methods in Enzymology , vol.400 , pp. 104-116
    • Court, M.H.1
  • 6
    • 50449083633 scopus 로고    scopus 로고
    • Novel polymorphic human UDP-glucuronosyltransferase (UGT) 2A3: Cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction
    • Court MH, Hazarika S, Krishnaswamy S, Finel M, Williams JA. (2008). Novel polymorphic human UDP-glucuronosyltransferase (UGT) 2A3: Cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction. Mol Pharmacol 74:744-754.
    • (2008) Mol Pharmacol , vol.74 , pp. 744-754
    • Court, M.H.1    Hazarika, S.2    Krishnaswamy, S.3    Finel, M.4    Williams, J.A.5
  • 7
    • 74549132748 scopus 로고    scopus 로고
    • Inter-individual variability in hepatic drug glucuronidation: Studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system
    • Court MH. (2010). Inter-individual variability in hepatic drug glucuronidation: Studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system. Drug Metab Rev 42:209-224.
    • (2010) Drug Metab Rev , vol.42 , pp. 209-224
    • Court, M.H.1
  • 9
  • 11
    • 0033564554 scopus 로고    scopus 로고
    • Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase
    • DOI 10.1042/0264-6021:3400837
    • Jedlitschky G, Cassidy AJ, Sales M, Pratt N, Burchell B. (1999). Cloning and characterization of a novel human olfactory UDPglucuronosyltransferase. Biochem J 340:837-843. (Pubitemid 29312884)
    • (1999) Biochemical Journal , vol.340 , Issue.3 , pp. 837-843
    • Jedlitschky, G.1    Cassidy, A.J.2    Sales, M.3    Pratt, N.4    Burchell, B.5
  • 13
    • 24944529235 scopus 로고    scopus 로고
    • Coupling of conjugating enzymes and efflux transporters: Impact on bioavailability and drug interactions
    • DOI 10.2174/138920005774330657
    • Jeong EJ, Liu X, Jia X, Chen J, Hu M. (2005). Coupling of conjugating enzymes and efflux transporters: Impact on bioavailability and drug interactions. Curr Drug Metab 6:455-468. (Pubitemid 41300790)
    • (2005) Current Drug Metabolism , vol.6 , Issue.5 , pp. 455-468
    • Jeong, E.J.1    Liu, X.2    Jia, X.3    Chen, J.4    Hu, M.5
  • 14
    • 0031570313 scopus 로고    scopus 로고
    • The regio-and stereo-selectivity of C19 and C21 hydroxysteroid glucuronidation by UGT2B7 and UGT2B11
    • DOI 10.1006/abbi.1997.9949
    • Jin CJ, Mackenzie PI, Miners JO. (1997). The regio-and stereoselectivity of C19 and C21 hydroxysteroid glucuronidation by UGT2B7 and UGT2B11. Arch Biochem Biophys 341:207-211. (Pubitemid 27203023)
    • (1997) Archives of Biochemistry and Biophysics , vol.341 , Issue.2 , pp. 207-211
    • Jin, C.-J.1    Mackenzie, P.I.2    Miners, J.O.3
  • 17
    • 77952349321 scopus 로고    scopus 로고
    • A molecular model of the human UDPglucuronosyltransferase 1A1, its membrane orientation, and the interactions between different parts of the enzyme
    • Laakkonen L, Finel M. (2010). A molecular model of the human UDPglucuronosyltransferase 1A1, its membrane orientation, and the interactions between different parts of the enzyme. Mol Pharmacol 77:931-939.
    • (2010) Mol Pharmacol , vol.77 , pp. 931-939
    • Laakkonen, L.1    Finel, M.2
  • 18
    • 0026090495 scopus 로고
    • Odorant signal termination by olfactory UDP glucuronosyl transferase
    • Lazard D, Zupko K, Poria Y, Nef P, Lazarovits J, Horn S, Khen M, Lancet D. (1991). Odorant signal termination by olfactory UDP glucuronosyl transferase. Nature 349:790-793. (Pubitemid 21912166)
    • (1991) Nature , vol.349 , Issue.6312 , pp. 790-793
    • Lazard, D.1    Zupko, K.2    Poria, Y.3    Nef, P.4    Lazarovits, J.5    Horn, S.6    Khen, M.7    Lancet, D.8
  • 22
    • 47949110575 scopus 로고    scopus 로고
    • Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines
    • Nakamura A, Nakajima M, Yamanaka H, Fujiwara R, Yokoi T. (2008). Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines. Drug Metab Dispos 36:1461-1464.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1461-1464
    • Nakamura, A.1    Nakajima, M.2    Yamanaka, H.3    Fujiwara, R.4    Yokoi, T.5
  • 23
    • 34147141506 scopus 로고    scopus 로고
    • Tissue-specific mRNA expression profiles of human phase i metabolizing enzymes except for cytochrome P450 and phase II metabolizing enzymes
    • Nishimura M, Naito S. (2006). Tissue-specific mRNA expression profiles of human phase I metabolizing enzymes except for cytochrome P450 and phase II metabolizing enzymes. Drug Metab Pharmacokinet 21:357-374.
    • (2006) Drug Metab Pharmacokinet , vol.21 , pp. 357-374
    • Nishimura, M.1    Naito, S.2
  • 24
    • 58149467072 scopus 로고    scopus 로고
    • Determination of mRNA expression of human UDP-glucuronosyltransferases and application for localization in various human tissues by real-time reverse transcriptasepolymerase chain reaction
    • Ohno S, Nakajin S. (2009). Determination of mRNA expression of human UDP-glucuronosyltransferases and application for localization in various human tissues by real-time reverse transcriptasepolymerase chain reaction. Drug Metab Dispos 37:32-40.
    • (2009) Drug Metab Dispos , vol.37 , pp. 32-40
    • Ohno, S.1    Nakajin, S.2
  • 27
    • 0023675927 scopus 로고
    • Similarity of unusual bile acids in human umbilical cord blood and amniotic fluid from newborns and in sera and urine from adult patients with cholestatic liver diseases
    • Shoda J, Mahara R, Osuga T, Tohma M, Ohnishi S, Miyazaki H, Tanaka N, Matsuzaki Y. (1988). Similarity of unusual bile acids in human umbilical cord blood and amniotic fluid from newborns and in sera and urine from adult patients with cholestatic liver diseases. J Lipid Res 29:847-858.
    • (1988) J Lipid Res , vol.29 , pp. 847-858
    • Shoda, J.1    Mahara, R.2    Osuga, T.3    Tohma, M.4    Ohnishi, S.5    Miyazaki, H.6    Tanaka, N.7    Matsuzaki, Y.8
  • 28
    • 73949103669 scopus 로고    scopus 로고
    • Human UDP-glucuronosyltransferase UGT2A2: CDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A
    • Sneitz N, Court MH, Zhang X, Laajanen K, Yee KK, Dalton P, Ding X, and Finel M. (2009). Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A. Pharmacogenet Genomics 19:923-934.
    • (2009) Pharmacogenet Genomics , vol.19 , pp. 923-934
    • Sneitz, N.1    Court, M.H.2    Zhang, X.3    Laajanen, K.4    Yee, K.K.5    Dalton, P.6    Ding, X.7    Finel, M.8
  • 29
    • 34748896235 scopus 로고    scopus 로고
    • A comparison of the expression and metabolizing activities of phase I and II enzymes in freshly isolated human lung parenchymal cells and cryopreserved human hepatocytes
    • DOI 10.1124/dmd.107.015966
    • Somers GI, Lindsay N, Lowdon BM, Jones AE, Freathy C, Ho S, Woodrooffe AJ, Bayliss MK, Manchee GR. (2007). A comparison of the expression and metabolizing activities of phase I and II enzymes in freshly isolated human lung parenchymal cells and cryopreserved human hepatocytes. Drug Metab Dispos 35:1797-1805. (Pubitemid 47481571)
    • (2007) Drug Metabolism and Disposition , vol.35 , Issue.10 , pp. 1797-1805
    • Somers, G.I.1    Lindsay, N.2    Lowdon, B.M.3    Jones, A.E.4    Freathy, C.5    Ho, S.6    Woodrooffe, A.J.M.7    Bayliss, M.K.8    Manchee, G.R.9
  • 30
    • 0036150897 scopus 로고    scopus 로고
    • Developmental aspects of human hepatic drug glucuronidation in young children and adults
    • DOI 10.1136/gut.0500259..
    • Strassburg CP, Strassburg A, Kneip S, Barut A, Tukey RH, Rodeck B, Manns MP. (2002). Developmental aspects of human hepatic drug glucuronidation in young children and adults. Gut 50:259-265. (Pubitemid 34087942)
    • (2002) Gut , vol.50 , Issue.2 , pp. 259-265
    • Strassburg, C.P.1    Strassburg, A.2    Kneip, S.3    Barut, A.4    Tukey, R.H.5    Rodeck, B.6    Manns, M.P.7
  • 31
    • 0032931896 scopus 로고    scopus 로고
    • Expression of the androgen metabolizing enzyme UGT2B15 in adipose tissue and relative expression measurement using a competitive RT-PCR method
    • DOI 10.1046/j.1365-2265.1999.00709.x
    • Tchernof A, Levesque E, Beaulieu M, Couture P, Despres JP, Hum DW, Belanger A. (1999). Expression of the androgen metabolizing enzyme UGT2B15 in adipose tissue and relative expression measurement using a competitive RT-PCR method. Clin Endocrinol 50:637-642. (Pubitemid 29236341)
    • (1999) Clinical Endocrinology , vol.50 , Issue.5 , pp. 637-642
    • Tchernof, A.1    Levesque, E.2    Beaulieu, M.3    Couture, P.4    Despres, J.-P.5    Hum, D.W.6    Belanger, A.7
  • 32
    • 0034128936 scopus 로고    scopus 로고
    • Human UDP-glucuronosyltransferases: Metabolism, expression, and disease
    • DOI 10.1146/annurev.pharmtox.40.1.581
    • Tukey RH, Strassburg CP. (2000). Human UDPglucuronosyltransferases: Metabolism, expression, and disease. Annu Rev Pharmacol Toxicol 40:581-616. (Pubitemid 30340694)
    • (2000) Annual Review of Pharmacology and Toxicology , vol.40 , pp. 581-616
    • Tukey, R.H.1    Strassburg, C.P.2
  • 33
    • 0035115599 scopus 로고    scopus 로고
    • Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract
    • Tukey RH, Strassburg CP. (2001). Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract. Mol Pharmacol 59:405-414. (Pubitemid 32179916)
    • (2001) Molecular Pharmacology , vol.59 , Issue.3 , pp. 405-414
    • Tukey, R.H.1    Strassburg, C.P.2
  • 34
    • 0035103197 scopus 로고    scopus 로고
    • Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members
    • DOI 10.1210/en.142.2.778
    • Turgeon D, Carrier JS, Levesque E, Hum DW, Belanger A. (2001). Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members. Endocrinology 142:778-787. (Pubitemid 32222427)
    • (2001) Endocrinology , vol.142 , Issue.2 , pp. 778-787
    • Turgeon, D.1    Carrier, J.-S.2    Levesque, E.3    Hum, D.W.4    Belanger, A.5
  • 38
    • 77950932971 scopus 로고    scopus 로고
    • Role of human UGT2B10 in N-glucuronidation of tricyclic antidepressants, amitriptyline, imipramine, clomipramine, and trimipramine
    • Zhou D, Guo J, Linnenbach AJ, Booth-Genthe CL, Grimm SW. (2010). Role of human UGT2B10 in N-glucuronidation of tricyclic antidepressants, amitriptyline, imipramine, clomipramine, and trimipramine. Drug Metab Dispos 38:863-870.
    • (2010) Drug Metab Dispos , vol.38 , pp. 863-870
    • Zhou, D.1    Guo, J.2    Linnenbach, A.J.3    Booth-Genthe, C.L.4    Grimm, S.W.5


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