Role of human UGT2B10 in N-glucuronidation of tricyclic antidepressants, amitriptyline, imipramine, clomipramine, and trimipramine

Drug Metabolism and Disposition

Volumn 38, Issue 5, 2010, Pages 863-870

  Zhou, Diansong ^a   Guo, Jian ^a   Linnenbach, Alban J ^a   Booth Genthe, Catherine L ^a,b   Grimm, Scott W ^a  

^a ASTRAZENECA   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; CLOMIPRAMINE; GLUCURONOSYLTRANSFERASE; IMIPRAMINE; TRIMIPRAMINE; UDP GLUCURONOSYLTRANSFERASE 2B10; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; GLUCURONIDATION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; KINETICS; LIVER MICROSOME; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

AMITRIPTYLINE; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BIOCATALYSIS; CLOMIPRAMINE; ENZYME INHIBITORS; GLUCURONIC ACID; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; IMIPRAMINE; KINETICS; MICROSOMES, LIVER; NICOTINE; RECOMBINANT PROTEINS; SAPOGENINS; TRIMIPRAMINE;

EID: 77950932971     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.030981     Document Type: Article

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