Losartan inhibits STAT1 activation and protects human glomerular mesangial cells from angiotensin II induced premature senescence

Canadian Journal of Physiology and Pharmacology

Volumn 90, Issue 1, 2012, Pages 89-98

  Jiao, Sumin ^a   Zheng, Xiaoyu ^a   Yang, Xue ^a   Zhang, Jin ^a   Wang, Lining ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Cellular senescence; Glomerular mesangial cells; Kidney ageing; Losartan; P53 p21cip1 pathway; STAT1 signaling

Indexed keywords

ACETYLCYSTEINE; ANGIOTENSIN II; BETA GALACTOSIDE; CYCLIN DEPENDENT KINASE INHIBITOR 1; LOSARTAN; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STAT1 PROTEIN;

ARTICLE; CELL AGING; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL SURVIVAL; HUMAN; HUMAN CELL; MESANGIUM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE;

ACETYLCYSTEINE; ANGIOTENSIN II; BETA-GALACTOSIDASE; CELL AGING; CELL CYCLE CHECKPOINTS; CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; ENZYME ACTIVATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; LOSARTAN; MESANGIAL CELLS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84862956409     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/Y11-105     Document Type: Article

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