Downregulation of connexin 43 expression by high glucose induces senescence in glomerular mesangial cells

Journal of the American Society of Nephrology

Volumn 17, Issue 6, 2006, Pages 1532-1542

  Zhang, Xiaojie ^a   Chen, Xiangmei ^a   Wu, Di ^a   Liu, Weiping ^a   Wang, Jianzhong ^a   Feng, Zhe ^a   Cai, Guangyan ^a   Fu, Bo ^a   Hong, Quan ^a   Du, Jing ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CONNEXIN 43; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; GLUCOSE; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; DIABETIC NEPHROPATHY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE TRANSFER; KNOCKOUT MOUSE; MALE; MESANGIUM CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA INTERFERENCE; SENESCENCE;

EID: 33646905626     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/ASN.2005070776     Document Type: Article

References (37)

1. Wolf G: Cell cycle regulation in diabetic nephropathy. Kidney Int 77[Suppl]: S59-S66, 2000
2. Wolf G, Reinking R, Zahner G, Stahl RA, Shankland SJ: Erk 1,2 phosphorylates p27(Kip1): Functional evidence for a role in high glucose-induced hypertrophy of mesangial cells. Diabetologia 46: 1090-1099, 2003
3. Al-Douahji M, Brugarolas J, Brown PA, Stehman-Breen CO, Alpers CE, Shankland SJ: The cyclin kinase inhibitor p21WAF1/CIP1 is required for glomerular hypertrophy in experimental diabetic nephropathy. Kidney Int 56: 1691-1699, 1999
4. Ben-Porath I, Weinberg RA: When cells get stressed: An integrative view of cellular senescence. J Clin Invest 113: 8-13, 2004
5. Zheng F, Plati AR, Banerjee A, Elliot S, Striker LJ, Striker GE: The molecular basis of age-related kidney disease. Sci Aging Knowledge Environ 29: 20-28, 2003
6. Blazer S, Khankin E, Segev Y, Ofir R, Yalon-Hacohen M, Kra-Oz Z, Gottfried Y, Larisch S, Skorecki KL: High glucose-induced replicative senescence: Point of no return and effect of telomerase. Biochem Biophys Res Commun 296: 93-101, 2002
7. Morocutti A, Earle KA, Sethi M, Piras G, Pal K, Richards D, Rodemann P, Viberti G: Premature senescence of skin fibroblasts from insulin-dependent diabetic patients with kidney disease. Kidney Int 50: 250-256, 1996
8. Fernandes R, Giro H, Pereira P: High glucose down-regulates intercellular communication in retinal endothelial cells by enhancing degradation of connexin 43 by a proteasome-dependent mechanism. J Biol Chem 279: 27219-27224, 2004
9. Kuroki T, Inoguchi T, Umeda F, Ueda F, Nawata H: High glucose induces alteration of gap junction permeability and phosphorylation of connexin-43 in cultured aortic smooth muscle cells. Diabetes 47: 931-936, 1998
10. Li AF, Sato T, Haimovici R, Okamoto T, Roy S: High glucose alters connexin 43 expression and gap junction intercellular communication activity in retinal pericytes. Invest Ophthalmol Vis Sci 44: 5376-5382, 2003
11. Sato T, Haimovici R, Kao R, Li AF, Roy S: Downregulation of connexin 43 expression by high glucose reduces gap junction activity in microvascular endothelial cells. Diabetes 51: 1565-1571, 2002
12. Li Z, Chen X, Xie Y, Shi S, Feng Z, Fu B, Zhang X, Cai G, Wu C, Wu D, Gu Y: Expression and significance of integrin-linked kinase in cultured cells, normal tissue, and diseased tissue of aging rat kidneys. J Gerontol A Biol Sci Med Sci 59: 984-996, 2004
13. Nagai K, Matsubara T, Mima A, Sumi E, Kanamori H, Iehara N, Fukatsu A, Yanagita M, Nakano T, Ishimoto Y, Kita T, Doi T, Aral H: Gas6 induces Akt/mTOR-mediated mesangial hypertrophy in diabetic nephropathy. Kidney Int 68: 552-561, 2005
14. Storrie B, Pepperkok R, Stelzer EH, Kreis TE: The intracellular mobility of a viral membrane glycoprotein measured by confocal microscope fluorescence recovery after photobleaching. J Cell Sci 107: 1309-1319, 1994
15. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T: Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498, 2001
16. Wu D, Chen X, Guo D, Hong Q, Fu B, Ding R, Yu L, Hou K, Feng Z, Zhang X, Wang J: Knockdown of fibronectin induces mitochondria-dependent apoptosis in rat mesangial cells. J Am Soc Nephrol 16: 646-657, 2005
17. Sharpless NE, DePinho RA: Telomeres, stem cells, senescence, and cancer. J Clin Invest 113: 160-168, 2004
18. Ho HY, Cheng ML, Lu FJ, Chou YH, Stern A, Liang CM, Chiu DT: Enhanced oxidative stress and accelerated cellular senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts. Free Radic Biol Med 29: 156-169, 2000
19. Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O: A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92: 9363-9367, 1995
20. Goodenough DA, Paul DL: Beyond the gap: Functions of unpaired connexon channels. Nat Rev Mol Cell Biol 4: 285-294, 2003
21. Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC: Plasma membrane channels formed by connexins: Their regulation and functions. Physiol Rev 83: 1359-1400, 2003
22. Statuto M, Bianchi C, Perego R, Del Monte U: Drop of connexin 43 7in replicative senescence of human fibroblasts HEL-299 as a possible biomarker of senescence. Exp Gerontol 37: 1113-1120, 2002
23. Jones SA, Lancaster MK, Boyett MR: Ageing-related changes of connexins and conduction within the sinoatrial node. J Physiol 560: 429-437, 2004
24. Yeh HI, Chang HM, Lu WW, Lee YN, Ko YS, Severs NJ, Tsai CH: Age-related alteration of gap junction distribution and connexin expression in rat aortic endothelium. J Histochem Cytochem 48: 1377-1389, 2000
25. Cotrina ML, Gao Q, Lin JH, Nedergaard M: Expression and function of astrocytic gap junctions in aging. Brain Res 901: 55-61, 2001
26. Dilley TK, Bowden GT, Chen QM: Novel mechanisms of sublethal oxidant toxicity: Induction of premature senescence in human fibroblasts confers tumor promoter activity. Exp Cell Res 290: 38-48, 2003
27. Guo R, Liu L, Barajas L: RT-PCR study of the distribution of connexin 43 mRNA in the glomerulus and renal tubular segments. Am J Physiol 275: R439-R447, 1998
28. Hillis GS, Duthie LA, Mlynski R, McKay NG, Mistry S, MacLeod AM, Simpson JG, Haites NE: The expression of connexin 43 in human kidney and cultured renal cells. Nephron 75: 458-463, 1997
29. Yao J, Morioka T, Oite T: PDGF regulates gap junction communication and connexin43 phosphorylation by PI 3-kinase in mesangial cells. Kidney Int 57: 1915-1926, 2000
30. Yao J, Suwa M, Li B, Kawamura K, Morioka T, Oite T: ATP-dependent mechanism for coordination of intercellular Ca2+ signaling and renin secretion in rat juxtaglomerular cells. Circ Res 93: 338-345, 2003
31. Ryan MJ, Liu B, Herbowy MT, Gross KW, Hajduczok G: Intercellular communication between renin expressing As4.1 cells, endothelial cells and smooth muscle cells. Life Sci 72: 1289-1301, 2003
32. Inoguchi T, Yu HY, Imamura M, Kakimoto M, Kuroki T, Maruyama T, Nawata H: Altered gap junction activity in cardiovascular tissues of diabetes. Med Electron Microsc 34: 86-91, 2001
33. Wolf G, Schroeder R, Zahner G, Stahl RA, Shankland SJ: High glucose-induced hypertrophy of mesangial cells requires p27(Kip1), an inhibitor of cyclin-dependent kinases. Am J Pathol 158: 1091-1100, 2001
34. Chkhotua AB, Gabusi E, Altimari A, D'Errico A, Yakubovich M, Vienken J, Stefoni S, Chieco P, Yussim A, Grigioni WF: Increased expression of p16(INK4a) and p27(Kip1) cyclin-dependent kinase inhibitor genes in aging human kidney and chronic allograft nephropathy. Am J Kidney Dis 41: 1303-1313, 2003
35. Alexander K, Hinds PW: Requirement for p27(KIP1) in retinoblastoma protein-mediated senescence. Mol Cell Biol 21: 3616-3631, 2001
36. Jirawatnotai S, Moons DS, Stocco CO, Franks R, Hales DB, Gibori G, Kiyokawa H: The cyclin-dependent kinase inhibitors p27Kip1 and p21Cip1 cooperate to restrict proliferative life span in differentiating ovarian cells. J Biol Chem 278: 17021-17027, 2003
37. Awazu M, Omori S, Ishikura K, Hida M, Fujita H: The lack of cyclin kinase inhibitor p27(Kip1) ameliorates progression of diabetic nephropathy. J Am Soc Nephrol 14: 699-708, 2003