The combined effect of sodium butyrate and low culture temperature on the production, sialylation, and biological activity of an antibody produced in CHO cells

Biotechnology and Bioprocess Engineering

Volumn 16, Issue 6, 2011, Pages 1157-1165

  Chen, Fei ^a   Kou, Tianci ^a   Fan, Li ^a   Zhou, Yan ^a   Ye, Zhaoyang ^a   Zhao, Liang ^a   Tan, Wen Song ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

CHO cells; Low culture temperature; N glycolylneuraminic acid; Sialylation; Sodium butyrate

Indexed keywords

ANTIBODIES; BIOACTIVITY; CARBOXYLIC ACIDS; CELL CULTURE; CELL DEATH; CELL PROLIFERATION; GLYCOSYLATION; SODIUM; SODIUM COMPOUNDS; TEMPERATURE;

CHO CELL; LOW CULTURE TEMPERATURE; N-GLYCOLYLNEURAMINIC ACID; SIALYLATION; SODIUM BUTYRATE;

LOW TEMPERATURE PRODUCTION;

BUTYRIC ACID; N GLYCOLOYLNEURAMINIC ACID; SIALIC ACID;

ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CELL CYCLE REGULATION; CELL GROWTH; CELL VIABILITY; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE TECHNIQUE; FLOW CYTOMETRY; GROWTH RATE; LOW TEMPERATURE PROCEDURES; PROTEIN QUATERNARY STRUCTURE; SIALYLATION; TEMPERATURE DEPENDENCE;

EID: 84862933227     PISSN: 12268372     EISSN: 19763816     Source Type: Journal    
DOI: 10.1007/s12257-011-0069-8     Document Type: Article

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