A new nonpeptide substrate of human sirtuin in a capillary electrophoresis-based assay. Investigation of the binding mode by docking experiments

Electrophoresis

Volumn 33, Issue 11, 2012, Pages 1652-1659

  Abromeit, Hans ^a   Kannan, Srinivasaraghaven ^b   Sippl, Wolfgang ^b   Scriba, Gerhard K E ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Capillary electrophoresis; Docking study; Enzyme assay; Molecular modeling; Sirtuin

Indexed keywords

ACETYLATION; AMINO ACIDS; BINDING ENERGY; CAPILLARY ELECTROPHORESIS; CELL DEATH; CELL PROLIFERATION; ENZYMES; ESTERS; SUBSTRATES;

BINDING MODES; CELL AGING; CELL PROLIFERATION/DIFFERENTIATION; DINUCLEOTIDES; DOCKING STUDIES; ENZYME ASSAYS; HISTONE DEACETYLASES; NONPEPTIDE SUBSTRATE; PHYSIOLOGICAL PROCESS; SIRTUIN;

AMIDES;

SIRTUIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CAPILLARY ELECTROPHORESIS; CARBOXY TERMINAL SEQUENCE; DEACETYLATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SUBSTRATE; HYDRODYNAMICS; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MICHAELIS MENTEN KINETICS; MOLECULAR DOCKING; MOLECULAR MODEL; PROTEIN BINDING; SEQUENCE HOMOLOGY; STRUCTURAL HOMOLOGY;

EID: 84862893727     PISSN: 01730835     EISSN: 15222683     Source Type: Journal    
DOI: 10.1002/elps.201100641     Document Type: Article

References (39)

1. Klar, A. J., Fogel, S., Macleod, K., Genetics 1979, 93, 37-50.
2. Shore, D., Squire, M., Nasmyth, K. A., EMBO J. 1984, 3, 2817-2823.
3. Frye, R. A., Biochem. Biophys. Res. Commun. 2000, 273, 793-798.
4. Luo, J., Nikolaev, A. Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., Gu, W., Cell 2001, 107, 137-148.
5. Daitoku, H., Hatta, M., Matsuzaki, H., Aratani, S., Ohshima, T., Miyagishi, M., Nakajima, T., Fukamizu, A., Proc. Natl. Acad. Sci. USA. 2004, 101, 10042-10047.
6. Fulco, M., Schiltz, R. L., Lezzi, S., King, M. T., Zhao, P., Kashiwaya, Y., Hoffman, E., Veech, R. L., Sartorelli, V., Mol. Cell 2003, 12, 51-62.
7. Avalos, J. L., Bever, K. M., Wolberger, C., Mol. Cell 2005, 17, 855-868.
8. Michan, S., Sinclair, D., Biochem. J. 2007, 404, 1-13.
9. Silva, J. P., Wahlestedt, C., Drug Discov. Today 2010, 15, 781-791.
10. Kaeberlein, M., McDonagh, T., Heltweg, B., Hixon, J., Westman, E. A., Caldwell, S. D., Napper, A., Curtis, R., DiStefano, P. S., Fields, S., Bedalov, A., Kennedy, B. K., J. Biol. Chem. 2005, 280, 17038-17045.
11. Blander, G., Olejnik, J., Krzymanska-Olejnik, E., McDonagh, T., Haigis, M., Yaffe, M. B., Guarente, L., J. Biol. Chem. 2005, 280, 9780-9785.
12. McDonagh, T., Hixon, J., DiStefano, P. S., Curtis, R., Napper, A. D., Methods 2005, 36, 346-350.
13. Kölle, D., Brosch, G., Lechner, T., Lusser, A., Loidl, P., Methods 1998, 15, 323-331.
14. Tanner, K. G., Landry, J., Sternglanz, R., Denu, J. M., Proc. Natl. Acad. Sci. USA. 2000, 97, 14178-14182.
15. de Boer, V. C. J., de Goffau, M. C., Arts, I. C. W., Hollman, P. C. H., Keijer, J., Mech. Ageing Dev. 2006, 127, 618-627.
16. Liu, Y., Gerber, R., Wu, J., Tsuruda, T., McCarter, J., Anal. Biochem. 2008, 378, 53-59.
17. Fan, Y., Ludewig, R., Imhof, D., Scriba, G. K. E., Electrophoresis 2008, 29, 3717-3723.
18. Fan, Y., Ludewig, R., Scriba, G. K. E., Anal. Biochem. 2009, 387, 243-248.
19. Marcotte, P., Richardson, P. R., Guo, J., Barrett, L. W., Xu, N., Gunasekera, A., Glaser, K. B., Anal. Biochem. 2004, 332, 90-99.
20. Schlicker, C., Gertz, M., Papatheodorou, P., Kachholz, B., Becker, C. F. W., Steegborn, C., J. Mol. Biol. 2008, 382, 790-801.
21. Borra, M. T., Smith, B. C., Denu, J. M., J. Biol. Chem. 2005, 280, 17187-17195.
22. Heltweg, B., Dequiedt, F., Verdin, E., Jung, M., Anal. Biochem. 2003, 319, 42-48.
23. Heltweg, B., Jung, M., Anal. Biochem. 2002, 302, 175-183.
24. Fan, Y., Hense, M., Ludewig, R., Weisgerber, C., Scriba, G. K. E., J. Pharm. Biomed. Anal. 2011, 54, 772-778.
25. Šali, A., Blundell, T. L., J. Mol. Biol. 1993, 234, 779-815.
26. Laskowski, R. A., MacArthur, M. W., Moss, D. S., Thornton, J. M., J. Appl. Crystallogr. 1993, 26, 283-291.
27. Wang, J., Cieplak, P., Kollman, P. A., J. Comput. Chem. 2000, 21, 1049-1074.
28. Jones, G., Willett, P., Glen, R. C., Leach, A. R., Taylor, R., J. Mol. Biol. 1997, 267, 727-748.
29. Zhang, C.-X., Thormann, W., Anal. Chem. 1996, 68, 2523-2532.
30. Qi, S., Huang, A., Sun, Y., Anal. Chem. 1996, 68, 1342-1346.
31. de Boer, T., Ensing, K., J. Chromatogr. A 1997, 788, 212-217.
32. Ritchie, R. J., Prvan, T., Biochem. Educ. 1996, 24, 196-206.
33. Grozinger, C. M., Chao, E. D., Blackwell, H. E., Moazed, D., Schreiber, S. L., J. Biol. Chem. 2001, 276, 38837-38843.
34. Trapp, J., Meier, R., Hongwiset, D., Kassack, M. U., Sippl, W., Jung, M., ChemMedChem 2007, 2, 1419-1431.
35. Mai, A., Massa, S., Lavu, S., Pezzi, R., Simeoni, S., Ragno, R., Mariotti, F. R., Chiani, F., Camilloni, G., Sinclair, D. A., J. Med. Chem. 2005, 48, 7789-7795.
36. Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., Scherer, B., Sinclair, D. A., Nature 2003, 425, 191-196.
37. Beher, D., Wu, J., Cumine, S., Kim, K. W., Lu, S.-C., Atangan, L., Wang, M., Chem. Biol. Drug Des. 2009, 74, 619-624.
38. Jin, L., Wei, W., Jiang, Y., Peng, H., Cai, J., Mao, C., Dai, H., Choy, W., Bemis, J. E., Jirousek, M. R., Milne, J. C., Westphal, C. H., Perni, R. B., J. Biol. Chem. 2009, 284, 24394-24405.
39. Hawse, W. F., Hoff, K. G., Fatkins, D. G., Daines, A., Zubkova, O. V., Schramm, V. L., Zheng, W., Wolberger, C., Structure 2008, 16, 1368-1377.