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Volumn 433, Issue 1-2, 2012, Pages 51-59

Conception, preparation and properties of functional carrier particles for pulmonary drug delivery

Author keywords

Functional carriers; Mucociliary clearance; Mucus; Powder properties; Spray drying

Indexed keywords

ACETYLCYSTEINE; DEXTRAN; DRUG CARRIER; MANNITOL;

EID: 84862890201     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.04.067     Document Type: Article
Times cited : (39)

References (77)
  • 1
    • 77953021975 scopus 로고    scopus 로고
    • Co-spray-dried mannitol-ciprofloxacin dry powder inhaler formulation for cystic fibrosis and chronic obstructive pulmonary disease
    • Adi, H., Young, P.M., Chan, H.K., Agus, H., Traini, D., 2010. Co-spray-dried mannitol-ciprofloxacin dry powder inhaler formulation for cystic fibrosis and chronic obstructive pulmonary disease. Eur. J. Pharm. Sci. 40, 239-247.
    • (2010) Eur. J. Pharm. Sci. , vol.40 , pp. 239-247
    • Adi, H.1    Young, P.M.2    Chan, H.K.3    Agus, H.4    Traini, D.5
  • 3
    • 0002754152 scopus 로고
    • The intravascular persistence of dextran of different molecular size in normal humans
    • Arturson, G., Wallenius, G., 1964. The intravascular persistence of dextran of different molecular size in normal humans. Scand. J. Clin. Lab. Invest. 16, 76-80.
    • (1964) Scand. J. Clin. Lab. Invest. , vol.16 , pp. 76-80
    • Arturson, G.1    Wallenius, G.2
  • 4
    • 33745001604 scopus 로고    scopus 로고
    • Mucin structure, aggregation, physiological functions and biomedical applications
    • DOI 10.1016/j.cocis.2005.11.001, PII S1359029405001184
    • Bansil, R., Turner, B.S., 2006. Mucin structure aggregation, physiological functions and biomedical applications. Curr. Opin. Colloid Interface Sci. 11, 164-170. (Pubitemid 43867390)
    • (2006) Current Opinion in Colloid and Interface Science , vol.11 , Issue.2-3 , pp. 164-170
    • Bansil, R.1    Turner, B.S.2
  • 5
    • 0030459932 scopus 로고    scopus 로고
    • Inhibition by dextran of Pseudomonos oeruginosa adherence to epithelial cells
    • Barghouthi, S., Guerdoud, L.M., Speert, D.P., 1996. Inhibition by dextran of Pseudomonos oeruginosa adherence to epithelial cells. Am. J. Respir. Crit. Care Med. 154, 1768-1793.
    • (1996) Am. J. Respir. Crit. Care Med. , vol.154 , pp. 1768-1793
    • Barghouthi, S.1    Guerdoud, L.M.2    Speert, D.P.3
  • 6
    • 26944440146 scopus 로고    scopus 로고
    • Distribution of receptor targets in the lung
    • Barnes, P.J., 2004. Distribution of receptor targets in the lung. Proc. Am. Thor. Soc. 1, 345-351.
    • (2004) Proc. Am. Thor. Soc. , vol.1 , pp. 345-351
    • Barnes, P.J.1
  • 8
    • 0029979921 scopus 로고    scopus 로고
    • Drug diffusion through cystic fibrotic mucus: Steady-state permeation, rheologic properties, and glycoprotein morphology
    • DOI 10.1021/js950381s
    • Bhat, P.G., Flanagan, D.R., Donovan, M.D., 1996. Drug diffusion through cystic fibrotic mucus: steady-state permeation, rheologic properties, and glycoprotein morphology. J. Pharm. Sci. 85, 624-630. (Pubitemid 26179102)
    • (1996) Journal of Pharmaceutical Sciences , vol.85 , Issue.6 , pp. 624-630
    • Bhat, P.G.1    Flanagan, D.R.2    Donovan, M.D.3
  • 9
    • 0035209735 scopus 로고    scopus 로고
    • Comparison of particle sizing techniques in the case of inhalation dry powders
    • DOI 10.1002/jps.1154
    • Bosquillon, C., Lombry, C., Preat, V., Vanbever, R., 2001a. Comparison of particle sizing techniques in the case of inhalation dry powders. J. Pharm. Sci. 90, 2032-2041. (Pubitemid 33144449)
    • (2001) Journal of Pharmaceutical Sciences , vol.90 , Issue.12 , pp. 2032-2041
    • Bosquillon, C.1    Lombry, C.2    Preat, V.3    Vanbever, R.4
  • 10
    • 0035936969 scopus 로고    scopus 로고
    • Influence of formulation excipients and physical characteristics of inhalation dry powders on their aerosolization performance
    • DOI 10.1016/S0168-3659(00)00362-X, PII S016836590000362X
    • Bosquillon, C., Lombry, C., Preat, V., Vanbever, R., 2001b. Influence of formulation excipients and physical characteristics of inhalation dry powders on their aerosolization performance. J. Control. Release 70, 329-339. (Pubitemid 32155456)
    • (2001) Journal of Controlled Release , vol.70 , Issue.3 , pp. 329-339
    • Bosquillon, C.1    Lombry, C.2    Preat, V.3    Vanbever, R.4
  • 11
    • 0028309683 scopus 로고
    • Human airway ion transport-part one
    • Boucher, R.C., 1994. Human airway ion transport-part one. Am. J. Respir. Crit. Care Med. 150, 271-281.
    • (1994) Am. J. Respir. Crit. Care Med. , vol.150 , pp. 271-281
    • Boucher, R.C.1
  • 13
    • 28844485771 scopus 로고    scopus 로고
    • The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: A phase 3 comparison study with hypertonic (4.5%) saline
    • Brannan, J., Anderson, S.D., Perry, C.P., Freed-Martens, R., Lassig, A.R., Charlton, B., 2005. The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline. Respir. Res. 6, 144.
    • (2005) Respir. Res. , vol.6 , pp. 144
    • Brannan, J.1    Anderson, S.D.2    Perry, C.P.3    Freed-Martens, R.4    Lassig, A.R.5    Charlton, B.6
  • 16
    • 60149089459 scopus 로고    scopus 로고
    • Barrier properties of mucus
    • Cone, R.A., 2009. Barrier properties of mucus. Adv. Drug Deliv. Rev. 61, 75-85.
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 75-85
    • Cone, R.A.1
  • 17
    • 48049116416 scopus 로고    scopus 로고
    • Dry powder platform for pulmonary drug delivery
    • Daniher, D.J., Zhu, J., 2008. Dry powder platform for pulmonary drug delivery. Particuology 6, 225-238.
    • (2008) Particuology , vol.6 , pp. 225-238
    • Daniher, D.J.1    Zhu, J.2
  • 18
    • 0002589791 scopus 로고    scopus 로고
    • Aerosols
    • Barnes, P.J., Grunstein, M.M., Leff, A.R., Woolcock, A.J. (Eds.), Lippincott-Raven Publishers, Philadelphia
    • Dolovich, M.B., 1997. Aerosols. In: Barnes, P.J., Grunstein, M.M., Leff, A.R., Woolcock, A.J. (Eds.), Asthma. Lippincott-Raven Publishers, Philadelphia, pp. 1349-1366.
    • (1997) Asthma , pp. 1349-1366
    • Dolovich, M.B.1
  • 19
    • 0028274838 scopus 로고
    • A review of the efficacy and safety of 7.5% NACL/6% dextran 70 in experimental animals and in humans
    • Dubick, M.A., Wade, C.E., 1994. A review of the efficacy and safety of 7.5% NaCl/6% dextran 70 in experimental animals and humans. J. Trauma 36, 323-330. (Pubitemid 24109450)
    • (1994) Journal of Trauma , vol.36 , Issue.3 , pp. 323-330
    • Dubick, M.A.1    Wade, C.E.2
  • 20
    • 27644578443 scopus 로고    scopus 로고
    • Particle size and density in spray drying - Effects of carbohydrate properties
    • DOI 10.1002/jps.20418
    • Elversson, J., Millqvist-Fureby, A., 2005. Particle size and density in spray drying-effects of carbohydrate properties. J. Pharm. Sci. 94, 2049-2060. (Pubitemid 41551488)
    • (2005) Journal of Pharmaceutical Sciences , vol.94 , Issue.9 , pp. 2049-2060
    • Elversson, J.1    Millqvist-Fureby, A.2
  • 22
    • 0031898528 scopus 로고    scopus 로고
    • Improved clearability of cystic fibrosis sputum with dextran treatment in vitro
    • Feng, W., Garrett, H., Speert, D.P., King, M., 1998. Improved clearability of cystic fibrosis sputum with dextran treatment in vitro. Am. J. Respir. Crit. Care Med. 157, 710-714.
    • (1998) Am. J. Respir. Crit. Care Med. , vol.157 , pp. 710-714
    • Feng, W.1    Garrett, H.2    Speert, D.P.3    King, M.4
  • 23
    • 0011581010 scopus 로고    scopus 로고
    • Effect of dextran molecular weight on CF sputum rigidity: Further evidence for the mechanism of action
    • Feng, W., Speert, D.P., King, M., 1997. Effect of dextran molecular weight on CF sputum rigidity: further evidence for the mechanism of action. Pediatr. Pulmonol. 14S, 273.
    • (1997) Pediatr. Pulmonol. , vol.14 S , pp. 273
    • Feng, W.1    Speert, D.P.2    King, M.3
  • 25
    • 14544277094 scopus 로고    scopus 로고
    • Dry powder inhalers for pulmonary drug delivery
    • DOI 10.1517/17425247.1.1.67
    • Frijlink, H.W., De Boer, A.H., 2004. Dry powder inhalers for pulmonary drug delivery. Expert Opin. Drug Deliv. 1, 67-86. (Pubitemid 40297957)
    • (2004) Expert Opinion on Drug Delivery , vol.1 , Issue.1 , pp. 67-86
    • Frijlink, H.W.1    De Boer, A.H.2
  • 26
    • 84872220068 scopus 로고    scopus 로고
    • Modelling of spray drying of multicomponent systems
    • in Polish
    • Gac, J., Gradoń, L., 2011. Modelling of spray drying of multicomponent systems. Inz. Ap. Chem. 50, 32-33 (in Polish).
    • (2011) Inz. Ap. Chem. , vol.50 , pp. 32-33
    • Gac, J.1    Gradoń, L.2
  • 27
    • 0017237409 scopus 로고
    • In situ rheological characterization of epithelial mucus
    • Gilboa, A., Silberberg, A., 1976. In situ rheological characterization of epithelial mucus. Biorheology 13, 59-65.
    • (1976) Biorheology , vol.13 , pp. 59-65
    • Gilboa, A.1    Silberberg, A.2
  • 28
    • 78649843015 scopus 로고    scopus 로고
    • Coarse-grained Monte Carlo simulations of mucus: Structure dynamics and thermodynamics
    • Gniewek, P., Kolinski, A., 2010. Coarse-grained Monte Carlo simulations of mucus: structure dynamics and thermodynamics. Biophys. J. 99, 3507-3516.
    • (2010) Biophys. J. , vol.99 , pp. 3507-3516
    • Gniewek, P.1    Kolinski, A.2
  • 29
    • 59349083375 scopus 로고    scopus 로고
    • Resuspension of particles from surfaces. Technological, environmental and pharmaceutical aspects
    • Gradoń, L., 2009. Resuspension of particles from surfaces. Technological, environmental and pharmaceutical aspects. Adv. Powder Technol. 20, 17-28.
    • (2009) Adv. Powder Technol. , vol.20 , pp. 17-28
    • Gradoń, L.1
  • 30
    • 0001282197 scopus 로고
    • Dry powder inhalers
    • Dalby, R.N., Byron, P.R., Farr, S.T. (Eds.), Academic Press, London
    • Granderton, D., Kassem, N.M., 1992. Dry powder inhalers. In: Dalby, R.N., Byron, P.R., Farr, S.T. (Eds.), Advanced Pharmaceutical Science. Academic Press, London, pp. 165-191.
    • (1992) Advanced Pharmaceutical Science , pp. 165-191
    • Granderton, D.1    Kassem, N.M.2
  • 31
    • 0028268210 scopus 로고
    • The relationship between the glass transition temperature and the water content of amorphous pharmaceutical solids
    • Hancock, B.C., Zografi, G., 1993. The relationship between the glass transition temperature and the water content of amorphous pharmaceutical solids. Pharm. Res. 11, 471-477.
    • (1993) Pharm. Res. , vol.11 , pp. 471-477
    • Hancock, B.C.1    Zografi, G.2
  • 33
    • 2242492170 scopus 로고    scopus 로고
    • Effect of oligomeric chain length on mucolytic and mucokinetic effects of oligosacharides
    • Hirji, M., Franklin, R., Feng, W., Boyd, W.A., King, M., 1998. Effect of oligomeric chain length on mucolytic and mucokinetic effects of oligosacharides. Am. J. Respir. Crit. Care Med. 159, A685.
    • (1998) Am. J. Respir. Crit. Care Med. , vol.159
    • Hirji, M.1    Franklin, R.2    Feng, W.3    Boyd, W.A.4    King, M.5
  • 34
    • 33745041254 scopus 로고    scopus 로고
    • Predicting the behavior of novel sugar carriers for dry powder inhaler formulations via the use of a cohesive-adhesive force balance approach
    • DOI 10.1002/jps.20618
    • Hooton, J.C., Jones, M.D., Price, R., 2006. Predicting the behavior of novel sugar carriers for dry powder inhaler formulations via the use of a cohesive-adhesive force balance approach. J. Pharm. Sci. 95, 1288-1297. (Pubitemid 43874442)
    • (2006) Journal of Pharmaceutical Sciences , vol.95 , Issue.6 , pp. 1288-1297
    • Hooton, J.C.1    Jones, M.D.2    Price, R.3
  • 35
    • 70350608409 scopus 로고    scopus 로고
    • The characterization and comparison of spray-dried mannitol samples
    • Hulse, W.L., Forbes, R.T., Bonner, M.C., Getrost, M., 2009. The characterization and comparison of spray-dried mannitol samples. Drug Dev. Ind. Pharm. 35, 712-718.
    • (2009) Drug Dev. Ind. Pharm. , vol.35 , pp. 712-718
    • Hulse, W.L.1    Forbes, R.T.2    Bonner, M.C.3    Getrost, M.4
  • 37
    • 64249100494 scopus 로고    scopus 로고
    • Production of morphology-controllable porous hyaluronic acid particles using a spray-drying method
    • Iskandar, F., Nanodiyanto, A., Widijastuti, W., Young, L.S., Okuyama, K., Gradoń, L., 2009. Production of morphology-controllable porous hyaluronic acid particles using a spray-drying method. Acta Biomater. 5, 1027-1034.
    • (2009) Acta Biomater. , vol.5 , pp. 1027-1034
    • Iskandar, F.1    Nanodiyanto, A.2    Widijastuti, W.3    Young, L.S.4    Okuyama, K.5    Gradoń, L.6
  • 38
    • 65649088979 scopus 로고    scopus 로고
    • Comparing the crystallization of sucrose and lactose in spray dryers
    • Islam, I.U., Langrish, T.A., 2009. Comparing the crystallization of sucrose and lactose in spray dryers. Food Bioprod. Process. 87, 87-95.
    • (2009) Food Bioprod. Process. , vol.87 , pp. 87-95
    • Islam, I.U.1    Langrish, T.A.2
  • 39
    • 23844553097 scopus 로고    scopus 로고
    • Surface roughness contribution to the adhesion force distribution of salmeterol xinafoate on lactose carriers by atomic force microscopy
    • DOI 10.1002/jps.20381
    • Islam, N., Stewart, P., et al., 2005. Surface roughness contribution to the adhesion force distribution of salmeterol xinafoate on lactose carriers by atomic force microscopy. J. Pharm. Sci. 94, 1500-1511. (Pubitemid 41168680)
    • (2005) Journal of Pharmaceutical Sciences , vol.94 , Issue.7 , pp. 1500-1511
    • Islam, N.1    Stewart, P.2    Larson, I.3    Hartley, P.4
  • 41
    • 77953915537 scopus 로고    scopus 로고
    • Engineered mannitol as an alternative carrier to enhance deep lung penetration of salbutamol sulphate from dry powder inhaler
    • Kaialy, W., Momin, M.N., Ticehurst, M.D., Murphy, J., Nokhodchi, A., 2010. Engineered mannitol as an alternative carrier to enhance deep lung penetration of salbutamol sulphate from dry powder inhaler. Colloids Surf. B: Biointerfaces 79, 345-356.
    • (2010) Colloids Surf. B: Biointerfaces , vol.79 , pp. 345-356
    • Kaialy, W.1    Momin, M.N.2    Ticehurst, M.D.3    Murphy, J.4    Nokhodchi, A.5
  • 44
    • 0024268336 scopus 로고
    • Airway responsiveness to inhaled and intravenous carbachol in sheep: Effect of airway mucus
    • Kim, C.S., Mungen, A.E., Eldridge, A., Wanner, A., 1988. Airway responsiveness to inhaled and intravenous carbachol in sheep: effect of airway mucus. J. Appl. Physiol. 65, 2744-2751. (Pubitemid 19026447)
    • (1988) Journal of Applied Physiology , vol.65 , Issue.6 , pp. 2744-2751
    • Kim, C.S.1    Eldridge, M.A.2    Wanner, A.3
  • 45
    • 70349427032 scopus 로고    scopus 로고
    • Mucus and its role in airway clearance and cytoprotection
    • Qutayba, H., Shannon, J., Martin, J. (Eds.), BC Decker Inc., Hamilton
    • King, M., 2005. Mucus and its role in airway clearance and cytoprotection. In: Qutayba, H., Shannon, J., Martin, J. (Eds.), Physiologic Basis of Respiratory Disease. BC Decker Inc., Hamilton, pp. 409-416.
    • (2005) Physiologic Basis of Respiratory Disease , pp. 409-416
    • King, M.1
  • 46
    • 0037027914 scopus 로고    scopus 로고
    • Pharmacological approaches to discovery and development of new mucolytic agents
    • DOI 10.1016/S0169-409X(02)00156-4, PII S0169409X02001564
    • King, M., Rubin, B.K., 2002. Pharmacological approaches to discovery and development of new mucolytic agents. Adv. Drug Deliv. Rev. 54, 1475-1490. (Pubitemid 35375771)
    • (2002) Advanced Drug Delivery Reviews , vol.54 , Issue.11 , pp. 1475-1490
    • King, M.1    Rubin, B.K.2
  • 47
    • 0022388267 scopus 로고
    • Alternation of airway reactivity by mucus
    • King, M., Kelly, S., Costo, M., 1985. Alternation of airway reactivity by mucus. Respir. Physiol. 62, 47-59.
    • (1985) Respir. Physiol. , vol.62 , pp. 47-59
    • King, M.1    Kelly, S.2    Costo, M.3
  • 48
    • 77951207948 scopus 로고    scopus 로고
    • Can low-dose combination products for inhalation be formulated in single crystalline particles?
    • Kumon, M., Kwok, P.C.L., Adi, H., Heng, D., Chan, H.K., 2010. Can low-dose combination products for inhalation be formulated in single crystalline particles? Eur J. Pharm. Sci. 40, 16-24.
    • (2010) Eur J. Pharm. Sci. , vol.40 , pp. 16-24
    • Kumon, M.1    Kwok, P.C.L.2    Adi, H.3    Heng, D.4    Chan, H.K.5
  • 49
    • 83655190654 scopus 로고    scopus 로고
    • Effects of process variables on the properties of spray-dried mannitol and mannitol/disodium cromoglycate powders suitable for drug delivery by inhalation
    • Kramek-Romanowska, K., Odziomek, M., Sosnowski, T.R., Gradoń, L., 2011. Effects of process variables on the properties of spray-dried mannitol and mannitol/disodium cromoglycate powders suitable for drug delivery by inhalation. Ind. Eng. Chem. Res. 50, 13922-13931.
    • (2011) Ind. Eng. Chem. Res. , vol.50 , pp. 13922-13931
    • Kramek-Romanowska, K.1    Odziomek, M.2    Sosnowski, T.R.3    Gradoń, L.4
  • 51
    • 0037452402 scopus 로고    scopus 로고
    • Influence of physico-chemical carrier properties on the in vitro aerosol deposition from interactive mixtures
    • DOI 10.1016/S0378-5173(02)00621-X, PII S037851730200621X
    • Louey, M.D., Razia, S., Stewart, P.J., 2003. Influence of physico-chemical carrier properties on the in vitro aerosol deposition from interactive mixtures. Int. J. Pharm. 252, 87-98. (Pubitemid 36126617)
    • (2003) International Journal of Pharmaceutics , vol.252 , Issue.1-2 , pp. 87-98
    • Louey, M.D.1    Razia, S.2    Stewart, P.J.3
  • 52
    • 29244452120 scopus 로고    scopus 로고
    • Enhancement of nasal absorption of large molecular weight compounds by combination of mucolytic agent and nonionic surfactant
    • DOI 10.1016/j.jconrel.2005.09.047, PII S0168365905005250
    • Matsuyama, T., Morita, T., Horikiri, Y., Yamahara, H., Yoshino, H., 2006. Enhancement of nasal absorption of large molecular weight compounds by combination of mucolytic agent and nonionic surfactant. J. Control. Release 110, 347-352. (Pubitemid 41827488)
    • (2006) Journal of Controlled Release , vol.110 , Issue.2 , pp. 347-352
    • Matsuyama, T.1    Morita, T.2    Horikiri, Y.3    Yamahara, H.4    Yoshino, H.5
  • 53
    • 0017711391 scopus 로고
    • Comparison of structural glycoproteins from mucus of different sources
    • Meyer, F.A., 1977. Comparison of structural glycoproteins from mucus of different sources. Biochim. Biophys. Acta 493, 272-282. (Pubitemid 8160592)
    • (1977) Biochimica et Biophysica Acta , vol.493 , Issue.2 , pp. 272-282
    • Meyer, F.A.1
  • 56
    • 33845906339 scopus 로고    scopus 로고
    • Inhaling medicines: Delivering drugs to the body through the lungs
    • DOI 10.1038/nrd2153, PII NRD2153
    • Patton, J.S., Byron, P.R., 2007. Inhaling medicines: delivering drugs to the body through the lungs. Nat. Rev. Drug Discov. 6, 67-74. (Pubitemid 46020287)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.1 , pp. 67-74
    • Patton, J.S.1    Byron, P.R.2
  • 57
    • 0343058935 scopus 로고    scopus 로고
    • Mechanisms of macromolecule absorption by the lungs
    • DOI 10.1016/0169-409X(95)00113-L
    • Patton, J.S., 1996. Mechanisms of macromolecule absorption by the lungs. Adv. Drug Deliv. Rev. 19, 3-36. (Pubitemid 26167852)
    • (1996) Advanced Drug Delivery Reviews , vol.19 , Issue.1 , pp. 3-36
    • Patton, J.S.1
  • 58
    • 0026572056 scopus 로고
    • Pulmonary delivery of peptides and proteins for systemic action
    • Patton, J.S., Platz, R.M., 1992. Pulmonary delivery of peptides and proteins for systemic action. Adv. Drug Deliv. Rev. 8, 179-228.
    • (1992) Adv. Drug Deliv. Rev. , vol.8 , pp. 179-228
    • Patton, J.S.1    Platz, R.M.2
  • 59
    • 84858624234 scopus 로고    scopus 로고
    • Lactose characteristics and the generation of the aerosols
    • Pilcer, G., Wauthoz, N., Amighi, K., 2012. Lactose characteristics and the generation of the aerosols. Adv. Drug Deliv. Rev. 64, 233-256.
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , pp. 233-256
    • Pilcer, G.1    Wauthoz, N.2    Amighi, K.3
  • 60
    • 0032834277 scopus 로고    scopus 로고
    • The effect of inhaled mannitol on bronchial mucus clearance in cystic fibrosis patients: A pilot study
    • DOI 10.1034/j.1399-3003.1999.14c30.x
    • Robinson, M., Daviskas, E., Eberl, S., Baker, J., Chan, H.K., Anderson, S.D., Bye, P.T., 1999. The effect of inhaled mannitol on bronchial mucus clearance in cystic fibrosis patients: a pilot study. Eur. Respir. J. 14, 678-685. (Pubitemid 29479736)
    • (1999) European Respiratory Journal , vol.14 , Issue.3 , pp. 678-685
    • Robinson, M.1    Daviskas, E.2    Eberl, S.3    Baker, J.4    Chan, H.-K.5    Anderson, S.D.6    Bye, P.T.P.7
  • 61
    • 3042761648 scopus 로고    scopus 로고
    • Insulin disposition in the lung following oral inhalation in humans: A meta-analysis of its pharmacokinetics
    • DOI 10.2165/00003088-200443080-00004
    • Sakagami, M., 2004. Insulin disposition in the lung following oral inhalation in humans: meta-analysis of its pharmacokinetics. Clin. Pharmacokinet. 43, 539-552. (Pubitemid 38858306)
    • (2004) Clinical Pharmacokinetics , vol.43 , Issue.8 , pp. 539-552
    • Sakagami, M.1
  • 62
    • 0018080161 scopus 로고
    • Structural basis for some permeability properties of the air-blood barrier
    • Schneeberger, E.E., 1978. Structural basis for some permeability properties of the air-blood barrier. Fed. Proc. 37, 2471-2478. (Pubitemid 9033819)
    • (1978) Federation Proceedings , vol.37 , Issue.11 , pp. 2471-2478
    • Schneeberger, E.E.1
  • 63
    • 0021682608 scopus 로고
    • Intercellular junctions in upper airway submucosal glands of the rat: A tracer and freeze fracture study
    • DOI 10.1002/ar.1092100303
    • Schneeberger, E.E., McCormack, J.M., 1984. Intercellular junctions in upper airway submucosal glands of the rat: a tracer and freeze-fracture study. Anat. Rec. 210, 421-433. (Pubitemid 15209464)
    • (1984) Anatomical Record , vol.210 , Issue.3 , pp. 421-433
    • Schneeberger, E.E.1    McCormack, J.M.2
  • 64
    • 22544457534 scopus 로고    scopus 로고
    • Carriers in drug powder delivery: Implications for inhalation system design
    • DOI 10.2165/00137696-200503020-00004
    • Smyth, H.D.C., Hickey, A.J., 2005. Carriers in drug powder delivery. Implications for inhalation system design. Am. J. Drug Deliv. 3, 117-132. (Pubitemid 41018283)
    • (2005) American Journal of Drug Delivery , vol.3 , Issue.2 , pp. 117-132
    • Smyth, H.D.C.1    Hickey, A.J.2
  • 65
    • 77954313947 scopus 로고    scopus 로고
    • Modification of inhalable powders by pulmonary surfactant components adsorbed on droplets during spray-drying process
    • Sosnowski, T.R., Gradoń, L., 2010. Modification of inhalable powders by pulmonary surfactant components adsorbed on droplets during spray-drying process. Colloid Surf. A 365, 56-61.
    • (2010) Colloid Surf. A , vol.365 , pp. 56-61
    • Sosnowski, T.R.1    Gradoń, L.2
  • 66
    • 31144457183 scopus 로고    scopus 로고
    • Effect of milling and sieving on functionality of dry powder inhalation products
    • DOI 10.1016/j.ijpharm.2005.10.043, PII S0378517305007647
    • Steckel, H., Markefka, P., et al., 2006. Effect of milling and sieving on functionality of dry powder inhalation products. Int. J. Pharm. 309, 51-59. (Pubitemid 43129464)
    • (2006) International Journal of Pharmaceutics , vol.309 , Issue.1-2 , pp. 51-59
    • Steckel, H.1    Markefka, P.2    TeWierik, H.3    Kammelar, R.4
  • 67
    • 0347021194 scopus 로고    scopus 로고
    • Alternative sugars as potential carriers for dry powder inhalations
    • DOI 10.1016/j.ijpharm.2003.10.039
    • Steckel, H., Bolzen, N., 2004. Alternative sugars as potential carriers for dry powder inhalations. Int. J. Pharm. 270, 297-306. (Pubitemid 38077109)
    • (2004) International Journal of Pharmaceutics , vol.270 , Issue.1-2 , pp. 297-306
    • Steckel, H.1    Bolzen, N.2
  • 69
    • 37349030374 scopus 로고    scopus 로고
    • Influence of various combinations of mucolytic agent and non-ionic surfactant on intestinal absorption of poorly absorbed hydrophilic compounds
    • DOI 10.1016/j.ijpharm.2007.07.031, PII S0378517307006436
    • Takatsuka, S., Morita, T., Horikiri, Y., Yamahara, H., Saji, H., 2008. Influence of various combinations of mucolytic agent and non-ionic surfactant on intestinal absorption of poorly absorbed hydrophillic compounds. Int. J. Pharm. 349, 94-100. (Pubitemid 350299692)
    • (2008) International Journal of Pharmaceutics , vol.349 , Issue.1-2 , pp. 94-100
    • Takatsuka, S.1    Morita, T.2    Horikiri, Y.3    Yamahara, H.4    Saji, H.5
  • 71
    • 0034605690 scopus 로고    scopus 로고
    • The use of different sugars as fine and coarse carriers for aerosolized salbutamol sulphate
    • Tee, S.K., Marriott, C., Zeng, X.M., Martin, G.P., 2000. The use of different sugars as fine and coarse carriers for aerosolized salbutamol sulphate. Int. J. Pharm. 208, 111-123.
    • (2000) Int. J. Pharm. , vol.208 , pp. 111-123
    • Tee, S.K.1    Marriott, C.2    Zeng, X.M.3    Martin, G.P.4
  • 73
    • 42049094490 scopus 로고    scopus 로고
    • Pharmaceutical particle engineering via spray drying
    • Vehring, R., 2008. Pharmaceutical particle engineering via spray drying. Pharm. Res. 25, 999-1002.
    • (2008) Pharm. Res. , vol.25 , pp. 999-1002
    • Vehring, R.1
  • 74
    • 84862868798 scopus 로고    scopus 로고
    • Dextran-based materials as excipients in engineered particle formulations: Tailoring physical properties to optimize performance. Manufacturability and safety
    • Dalby, R.N., Byron, P.R., Peart, J., Suman, J.D., Young, P.M. (Eds.), Virgina Commonwealth University, Richmond
    • Vodak, D.T., Dobry, D.E., Friesen, D., Reed, M., Gigliotti, A.P., Kuehl, P., Lyon, D.K., 2011. Dextran-based materials as excipients in engineered particle formulations: tailoring physical properties to optimize performance. Manufacturability and safety. In: Dalby, R.N., Byron, P.R., Peart, J., Suman, J.D., Young, P.M. (Eds.), RDD Europe 2011. Virgina Commonwealth University, Richmond, pp. 125-134.
    • (2011) RDD Europe 2011 , pp. 125-134
    • Vodak, D.T.1    Dobry, D.E.2    Friesen, D.3    Reed, M.4    Gigliotti, A.P.5    Kuehl, P.6    Lyon, D.K.7
  • 75
    • 78650126260 scopus 로고    scopus 로고
    • Formulation of highly ordered nanostructures by drying micrometer colloidal droplets
    • Young, L.S., Gradoń, L., Janeczko, S., Iskandar, F., Okuyama, K., 2010. Formulation of highly ordered nanostructures by drying micrometer colloidal droplets. ACS Nano 4, 4714-4724.
    • (2010) ACS Nano , vol.4 , pp. 4714-4724
    • Young, L.S.1    Gradoń, L.2    Janeczko, S.3    Iskandar, F.4    Okuyama, K.5
  • 76
    • 34249281670 scopus 로고    scopus 로고
    • The influence of mechanical processing of dry powder inhaler carriers on drug aerosolization performance
    • DOI 10.1002/jps.20933
    • Young, P.M., Chan, H.-K., et al., 2007a. The influence of mechanical processing of dry powder inhaler carriers on drug aerosolization performance. J. Pharm. Sci. 96, 1331-1341. (Pubitemid 46804584)
    • (2007) Journal of Pharmaceutical Sciences , vol.96 , Issue.5 , pp. 1331-1341
    • Young, P.M.1    Chan, H.-K.2    Chiou, H.3    Edge, S.4    Tee, T.H.S.5    Traini, D.6
  • 77
    • 0033066810 scopus 로고    scopus 로고
    • Effects of particle size and adding sequence of fine lactose on the deposition of salbutamol sulphate from a dry powder formulation
    • DOI 10.1016/S0378-5173(99)00021-6, PII S0378517399000216
    • Zeng, X.M., Martin, G.P., et al., 1999. Effects of particle size and adding sequence of fine lactose on the deposition of salbutamol sulphate from a dry powder formulation. Int. J. Pharm. 182, 133-144. (Pubitemid 29248842)
    • (1999) International Journal of Pharmaceutics , vol.182 , Issue.2 , pp. 133-144
    • Zeng, X.M.1    Martin, G.P.2    Tee, S.-K.3    Ghoush, A.A.4    Marriott, C.5


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