Can low-dose combination products for inhalation be formulated in single crystalline particles?

European Journal of Pharmaceutical Sciences

Volumn 40, Issue 1, 2010, Pages 16-24

  Kumon, Michiko ^a   Kwok, Philip Chi Lip ^a   Adi, Handoko ^a   Heng, Desmond ^b   Chan, Hak Kim ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b INSTITUTE OF CHEMICAL AND ENGINEERING SCIENCES   (Singapore)

Author keywords

Co spray drying; Combination product; Inhaled corticosteroid (ICS); Long acting 2 agonist (LABA); Mannitol

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE PLUS FORMOTEROL; CORTICOSTEROID DERIVATIVE; CRYSTALLIN; FLUTICASONE PROPIONATE PLUS SALMETEROL; LONG ACTING DRUG; MANNITOL; SILICA GEL; ANDROSTANE DERIVATIVE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; CORTICOSTEROID; DRUG COMBINATION; ETHANOLAMINE DERIVATIVE; FLUTICASONE, SALMETEROL DRUG COMBINATION; FORMOTEROL; SALBUTAMOL;

AEROSOL; ARTICLE; CONTROLLED STUDY; DISPERSION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG STABILITY; DRUG STORAGE; PARTICLE SIZE; PHYSICAL CHEMISTRY; POWDER; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; ANALOGS AND DERIVATIVES; ATOMIC FORCE MICROSCOPY; CHEMISTRY; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG COMBINATION; HUMAN; INHALATIONAL DRUG ADMINISTRATION; MEDICINAL CHEMISTRY; PROCEDURES; SURFACE PROPERTY; TRANSITION TEMPERATURE; X RAY DIFFRACTION; X RAY PHOTOELECTRON SPECTROSCOPY;

ADMINISTRATION, INHALATION; ADRENAL CORTEX HORMONES; ADRENERGIC BETA-AGONISTS; ALBUTEROL; ANDROSTADIENES; BUDESONIDE; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DRUG COMBINATIONS; ETHANOLAMINES; HUMANS; MANNITOL; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; PHOTOELECTRON SPECTROSCOPY; SURFACE PROPERTIES; TRANSITION TEMPERATURE; X-RAY DIFFRACTION;

EID: 77951207948     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2010.02.004     Document Type: Article

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