Influence of various combinations of mucolytic agent and non-ionic surfactant on intestinal absorption of poorly absorbed hydrophilic compounds

International Journal of Pharmaceutics

Volumn 349, Issue 1-2, 2008, Pages 94-100

  Takatsuka, Shinya ^a   Morita, Takahiro ^a   Horikiri, Yuji ^a   Yamahara, Hiroshi ^a   Saji, Hideo ^b  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Combination; Intestinal absorption; Mucolytic agent; Polyoxyethylene alkyl ethers; Poorly absorbed hydrophilic compounds

Indexed keywords

ACETYLCYSTEINE; BL 10; BL 20; BL 21; BL 25; BL 42; BO 10; BO 15; BO 7; BS 20; CARBOCISTEINE; CETYL POLY (10) OXYETHYLENE ETHER; CETYL POLY (20) OXYETHYLENE ETHER; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; LAURYL POLY (21) OXYETHYLENE ETHER; LAURYL POLY (25) OXYETHYLENE ETHER; LAURYL POLY (4.2) OXYETHYLENE ETHER; MUCOLYTIC AGENT; NONIONIC SURFACTANT; OLEYL POLY (10) OXYETHYLENE ETHER; OLEYL POLY (15) OXYETHYLENE ETHER; OLEYL POLY (7) OXYETHYLENE ETHER; POLIDOCANOL; POLYOXYETHYLENE; POLYOXYETHYLENE ALKYL ETHER; S ETHYLCYSTEINE; S METHYLCYSTEINE; STEARYL POLY (20) OXYETHYLENE ETHER; THIOL GROUP; TRITON X 100; TYLOXAPOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; INTESTINE ABSORPTION; JEJUNUM; MALE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETYLCYSTEINE; ANIMALS; AREA UNDER CURVE; CHEMISTRY, PHYSICAL; DEXTRANS; EXPECTORANTS; FLUORESCEIN-5-ISOTHIOCYANATE; INTESTINAL ABSORPTION; KINETICS; MALE; PHARMACEUTICAL PREPARATIONS; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE-ACTIVE AGENTS;

EID: 37349030374     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.07.031     Document Type: Article

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