Low-temperature aerosol flow reactor method for preparation of surface stabilized pharmaceutical nanocarriers

Journal of Aerosol Science

Volumn 42, Issue 10, 2011, Pages 645-656

  Torvela, Tiina ^a   Lähde, Anna ^a   Mönkäre, Juha ^a   Riikonen, Joakim ^a   Lehtinen, Kari E J ^a,b   Järvinen, Kristiina ^a   Lehto, Vesa Pekka ^a   Jokiniemi, Jorma ^a,c   Joutsensaari, Jorma ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b FINNISH METEOROLOGICAL INSTITUTE   (Finland)

^c VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

Author keywords

Drug delivery; Gas phase synthesis; Polymeric nanoparticles; Surface coating

Indexed keywords

AEROSOLS; AMINO ACIDS; BIODEGRADABLE POLYMERS; COATINGS; CONTROLLED DRUG DELIVERY; DRUG DELIVERY; FLOW OF GASES; NANOPARTICLES; PROTEINS; TARGETED DRUG DELIVERY; TEMPERATURE;

GAS-PHASE SYNTHESIS; LOW PROCESS TEMPERATURE; PHARMACEUTICAL NANOPARTICLES; PHENYLEPHRINE HYDROCHLORIDE; POLYMERIC NANOPARTICLES; SURFACE COATINGS; SURFACE STABILIZATION; SYNTHESIS TEMPERATURES;

SYNTHESIS (CHEMICAL);

EUDRAGIT; LEUCINE; NANOCARRIER; NANOCOATING; PHENYLEPHRINE;

AEROSOL COMPOSITION; AGGLOMERATION; AIR TEMPERATURE; BIODEGRADATION; COATING; DRUG; GAS FLOW; LOW TEMPERATURE; POLYMER; ULTRASTRUCTURE;

AEROSOL; ARTICLE; BIOREACTOR; DRUG COATING; DRUG DELIVERY SYSTEM; GAS; HYDRODYNAMICS; LOW TEMPERATURE; PARTICLE SIZE; PHASE TRANSITION; PRIORITY JOURNAL; SOLID; TEMPERATURE SENSITIVITY; VAPOR;

EID: 79960441336     PISSN: 00218502     EISSN: 18791964     Source Type: Journal    
DOI: 10.1016/j.jaerosci.2011.06.006     Document Type: Article

References (36)

1. Allen T.M., Cullis P.R. Drug delivery systems: Entering the mainstream. Science 2004, 303:1818-1822.
2. Bird R.B., Stewart W.E., Lightfoot E.N. Transport Phenomena 2008, John Wiley & Sons, Singapore, India, Asia. 2nd ed.
3. Chew N.Y., Shekunov B.Y., Tong H.H., Chow A.H., Savage C., Wu J., Chan H.-K. Effect of amino acids on the dispersion of disodium cromoglycate powders. Journal of Pharmaceutical Sciences 2005, 94:2289-2300.
4. DeCarlo P., Slowik J., Worsnop D., Jimenez J. Particle morphology and density characterization by combined mobility and aerodynamic diameter measurements: Part 1: Theory. Aerosol Science and Technology 2004, 38:1185-1205.
5. Eerikäinen H., Kauppinen E.I. Preparation of polymeric nanoparticles containing corticosteroid by a novel aerosol flow reactor method. International Journal of Pharmaceutics 2003, 263:69-83.
6. Eerikäinen H., Watanabe W., Kauppinen E.I., Ahonen P.P. Aerosol flow reactor method for synthesis of drug nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics 2003, 55:357-360.
7. Ehara K., Hagwood C., Coakley K.J. Novel method to classify aerosol particles according to their mass-to-charge ratio-aerosol particle mass analyzer. Journal of Aerosol Science 1996, 27:217-234.
8. Gittings M.R., Saville D.A. The determination of hydrodynamic size and zeta potential from electrophoretic mobility and light scattering measurements. Colloids and Surfaces A: Physicochemical and Engineering Aspects 1998, 141:111-117.
9. Haas V., Birringer R., Gleiter H., Pratsinis S.E. Synthesis of nanostructured powders in an aerosol flow condenser. Journal of Aerosol Science 1997, 28:1443-1453.
10. Hasegawa K., Miyashita S., Komatsu H., Sano C., Nagashima N. In-situ observation of the concentration gradient layer around a growing crystal of leucine complex. Journal of Crystal Growth 1996, 166:925-929.
11. Hinds W. Aerosol Technology: Properties, Behaviour and Measurement of Airborne Particles 1992, John Wiley & Sons Inc, New Jersey, USA. 2nd ed.
12. Järvinen K., Pulkkinen M., Hirvonen J., Hirsjärvi S., Peltonen L. Preparation and characterization of polymeric nanoparticles and microparticles for pharmaceutical applications. Handbook of Particulate Drug Delivery 2008, vol. 1:17-34. American Scientific Publishers.
13. Kelly W.P., McMurry P. Measurement of particle density by inertial classification of differential mobility analyzer-generated monodisperse aerosols. Aerosol Science and Technology 1992, 17:199-212.
14. Lähde A., Raula J., Kauppinen E.I. Combined synthesis and in situ coating of nanoparticles in the gas phase. Journal of Nanoparticle Research 2008, 10:121-130.
15. Lähde, A., Raula, J., & Kauppinen, E.I. (2008b). Production of l-leucine nanoparticles under various conditions using an aerosol flow reactor method. Journal of Nanomaterials, 2008, 9 pp. (Article ID 680897). doi:. http://10.1155/2008/680897.
16. Lähde A., Raula J., Kauppinen E.I. Sublimation kinetics and vapour pressure estimation of l-leucine using thermogravimetric analysis. Thermochimica Acta 2009, 482:17-20.
17. Lähde A., Raula J., Kauppinen E.I., Watanabe W., Ahonen P.P., Brown D.P. Aerosol synthesis of inhalation particles via droplet-to-particle method. Particulate Science and Technology 2006, 24:71-84.
18. Lassalle V., Ferreira M.L. PLA nano- and microparticles for drug delivery: an overview of the methods of preparation. Macromolecular Bioscience 2007, 7:767-783.
19. Lehtinen K.E.J., Kulmala M. A model for particle formation and growth in the atmosphere with molecular resolution in size. Atmospheric Chemistry and Physics 2003, 3:251-257.
20. Li J., Wang Z., Yang X., Hu L., Liu Y., Wang C. Decomposing or subliming? An investigation of thermal behavior of l-leucine. Thermochimica Acta 2006, 447:147-153.
21. Lide, D.R. (Ed.) (2005). Handbook of Chemistry and Physics (86th ed.). Taylor & Francis Group: FL, USA.
22. McMurry P.H., Wang X., Park K., Ehara K. The relationship between mass and mobility for atmospheric particles: a new technique for measuring particle density. Aerosol Science and Technology 2002, 36:227-238.
23. O'Neil, M.J. (Ed.) (2006). The Merck Index: The Encyclopedia of Chemicals, Drugs, and Biologicals (14th ed.). Whitehouse Station: New Jersey, USA.
24. Paajanen M., Jatainen J., Raula J., Kauppinen E.I., Lahtinen J. Direct evidence on reduced adhesion of salbutamol sulphate particles due to l-leucine coating. Powder Technology 2009, 192:6-11.
25. Pinto Reis C., Neufeld R.J., Ribeiro A.J., Veiga F. Nanoencapsulation I: methods for preparation of drug-loaded polymeric nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine 2006, 2:8-21.
26. Raula J., Kuivanen A., Lähde A., Jiang H., Antopolsky M., Kansikas J., Kauppinen E.I. Synthesis of l-leucine nanoparticle via physical vapor deposition at varying saturation conditions. Journal of Aerosol Science 2007, 38:1172-1184.
27. Raula J., Lähde A., Kauppinen E.I. A novel gas phase method for the combined synthesis and coating of pharmaceutical particles. Pharmaceutical Research 2008, 25:242-245.
28. Raula J., Thielmann F., Kansikas J., Hietala S., Annala M., Seppälä J., Lähde A., Kauppinen E.I. Investigations on the humidity-induced transformations of salbutamol sulphate particles coated with l-leucine. Pharmaceutical Research 2008, 25:2250-2261.
29. Raula J., Thielmann F., Naderi M., Lehto V.-P., Kauppinen E.I. Investigations on particle surface characteristics vs. dispersion behaviour of l-leucine coated carrier-free inhalable powders. International Journal of Pharmaceutics 2010, 385:79-85.
30. Schmid O., Karg E., Hagen D.E., Whitefield P.D., Ferron G.A. On the effective density of non-spherical particles as derived from combined measurements of aerodynamic and mobility equivalent size. Journal of Aerosol Science 2007, 38:431-443.
31. Seinfeld J., Pandis S. Atmospheric Chemistry and Physics: From Air Pollution to Climate Change 2006, John Wiley & Sons Inc, New Jersey, USA. 2nd ed.
32. Seville P.C., Learoyd T.P., Li H.-Y., Williamson I.J., Birchall J.C. Amino acid-modified spray-dried powders with enhanced aerosolisation properties for pulmonary drug delivery. Powder Technology 2007, 178:40-50.
33. Vehring R. Pharmaceutical particle engineering via spray drying. Pharmaceutical Research 2008, 25:999-1022.
34. Vehring R., Foss W.R., Lechuga-Ballesteros D. Particle formation in spray drying. Aerosol Science 2007, 38:728-746.
35. Vonarbourg A., Passirani C., Saulnier P., Benoit J.-P. Parameters influencing the stealthiness of colloidal drug delivery systems. Biomaterials 2006, 27:4356-4373.
36. Yap S.F., Adams M.J., Seville J.P., Zhang Z. Single and bulk compression of pharmaceutical excipients: Evaluation of mechanical properties. Powder Technology 2008, 185:1-10.