Achetylcholinesterase (AchE) inhibition and serum lipokines in Alzheimer's disease: Friend or foe?;Acetilkolin-észteráz gátlás és szérum lipokinek Alzheimer-kórban: Barát vagy ellenség?

Neuropsychopharmacologia Hungarica

Volumn 14, Issue 1, 2012, Pages 19-27

  János, Kovács ^a   Magdolna, Pákáski ^a   Anna, Juhász ^a   Ágnes, Fehér ^a   Gergely, Drótos ^a   Csilla, Fazekas Örsike ^a   Tamás, Horváth László ^b   Zoltán, Janka ^a   János, Kálmán ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adiponectin; Alzheimer's disease; Apolipoprotein E; Bodyweight; Dementia; Donepezil; Leptin; Lipid; Lipokine

Indexed keywords

ACETYLCHOLINESTERASE; ADIPOCYTOKINE; ADIPONECTIN; APOLIPOPROTEIN E; CHOLINESTERASE INHIBITOR; DONEPEZIL; HIGH DENSITY LIPOPROTEIN; LEPTIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ALLELE; ALZHEIMER DISEASE; ARTICLE; BODY MASS; CLINICAL ARTICLE; DISEASE SEVERITY; ENERGY CONSUMPTION; ENZYME INHIBITION; GLUCOSE METABOLISM; HUMAN; HYPOTHALAMUS; LIPID METABOLISM; LONG TERM CARE; SELF EVALUATION; WEIGHT REDUCTION;

ADIPOKINES; ADIPONECTIN; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOLIPOPROTEINS E; APPETITE; BIOLOGICAL MARKERS; BODY MASS INDEX; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CHOLINESTERASE INHIBITORS; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; HUNGARY; INDANS; LEPTIN; LIPID METABOLISM; MALE; MIDDLE AGED; NOOTROPIC AGENTS; OUTPATIENTS; PIPERIDINES; POLYMORPHISM, SINGLE NUCLEOTIDE; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TREATMENT OUTCOME; TRIGLYCERIDES; WAIST CIRCUMFERENCE;

EID: 84862838271     PISSN: 14198711     EISSN: None     Source Type: Journal    
DOI: 10.5706/nph201203002     Document Type: Article

References (65)

1. Adunsky, A., Chesnin, V., Ravona, R., Harats, D., Davidson, M. (2004) Plasma lipid levels in Alzheimer's disease patients treated by Donepezil hydrochloride: a cross-sectional study. Arch Gerontol Geriatr, 38:61-68.
2. Antal, M., Regöly-Mérei, A. (2010) Szemléletváltás a Zsírszövet megítélésében. Orv Hetil, 151:1252-1260.
3. Antal, M., Regöly-Mérei, A., Nagy, K., Bíró, L., Péter, Sz., Arató, Gy., Szabó, Cs., Lásztity, N., Martos, É. (2008) Van-e kitüntetett mérõmódszer az elhízás megállapítására? Orv Hetil, 149: 1943-1948.
4. Beck, A.T., Ward, C.H., Mendelson, M., Mock, J., Erbaugh, J. (1961) An inventory for measuring depression. Arch Gen Psych, 4:561-571.
5. Berg, A.H., Combs, T.P., Scherer, P.E. (2002) ACRP30/adiponectin:an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab, 13:84-89.
6. Bigalke, B., Schreitmüller, B., Sopova, K., Paul, A., Stransky, E., Gawaz, M., Stellos, K., Laske, C. (2011) Adipocytokines and CD34+ progenitor cells in Alzheimer's disease. Plos One, Epub.
7. Blaha, V., Yang, Z.J., Meguid, M., Chai, J.K., Zadak, Z. (1998) Systemic nicotine administration suppresses food intake via reduced meal sizes in both male and female rats. Acta Med, 41:167-173.
8. Calvani, M., Scarfone, A., Granato, L., Mora, E.V., Nanni, G., Castagneto, M., Greco, A.V., Manco, M., Mingrone, G. (2004) Restoration of adiponectine pulsatility in severely obese subjects after weight loss. Diabetes, 53:939-947.
9. Couce, M.E., Burguera, B., Parisi, J.E., Jensen, M.D., Lloyd, R.V. (1997) Localization of leptin receptor in the human brain. Neuroendocrinology, 66:145-150.
10. Dötsch, J., Adelmann, M., Englaro, P., Dötsch, A., Hänze, J., Blum, W.F., Kiess, W., Rascher, W. (1997) Relation of leptin and neuropeptide Y in human blood and cerebrospinal fluid. J Neurol Sci Oct 22, 151(2):185-8.
11. Eliasson, B., Smith, U. (1999) Leptin levels in smokers and long-term users of nicotine gum. Eur J Clin Invest, 29:145-152.
12. Farr, S.A., Banks, W.A., Morley, J.E. (2006) Effects of leptin on memory processing. Peptides, 27:1420-1425.
13. Ferri, C.P., Prince, M., Brayne, C., Brodaty, H., Fratiglioni, L., Ganguli, M., Hall, K., Hasegawa, K., Hendrie, H., Huang, Y., Jorm, A., Mathers, C., Menezes, P.R., Rimmer, E., Scazufca, M., (2005) Alzheimer's Disease International. Global prevalence of dementia: a Delphi consensus study. Lancet, 366: 2112-2117.
14. Fewlass, D.C., Noboa, K., Pi-Sunyer, F.X., Johnston, J.M., Yan, S.D., Tezapsidis, N. (2004) Obesity-related leptin regulates Alzheimer's Abeta. FASEB J, 18:1870-1878.
15. Folstein, M.F., Folstein, S.E., McHugh, P.R. "Mini Mental State". (1975) A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res, 12:189-198.
16. Frühbeck, G. (2006) Intracellular signalling pathways activated by leptin. Biochem J, 393: 7-20.
17. Frühbeck, G. (2008) Overview of adipose tissue and its role in obesity and metabolic disorders. Methods Mol Biol, 456:1-22.
18. Garza, J.C., Guo, M., Zhang, W., Lu, X.Y. (2008) Leptin increases adult hippocampal neurogenesis in vivo and in vitro. J Biol Chem, 283:18238-18247.
19. Greco, S.J., Sarkar, S., Johnston, J.M., Tezapsidis, N. (2009) Leptin regulates Tau phosphorylation and amyloid through AMPK in neuronal cells Biochem Biophys Res Commun, 380: 98-104.
20. Grunberg, N.E. (1985) Nicotine, cigarette smoking, and body weight, Br J Addict, 80:369-377.
21. Gustafson, D., Rothenberg, E., Blennow, K., Steen, B., Skoog, I. (2003) An 18- year follow-up of overweight and risk of Alzheimer disease. Arch Intern Med, 163:1524-1528.
22. Harvey, J., Shanley, L.J., O'Malley, D., Irving, A.J. (2005) Leptin: a potential cognitive enhancer? Biochem Soc Trans, 33:1029-1032.
23. Hegyi, K., Fulop, K., Kovacs, K., Toth, S., Falus, A. (2004) Leptin-induced signal transduction pathways. Cell Biol Int, 28:159-169.
24. Hodge, A.M., Westerman, R.A., de Courten, M.P., Collier, G.R., Zimmet, P.Z., Alberti, K.G. (1997) Is leptin sensitivity the link between smoking cessation and weight gain? Int J Obes Relat Metab Disord, 21:50-53.
25. Isidori, A.M., Strollo, F., More, M., Caprio, M., Aversa, A., Moretti, C., Frajese, G., Riondino, G., Fabbri, A. (2000) Leptin and aging: correlation with endocrine changes in male and female healthy adult populations of different body weights. J Clin Endocrinol Metab, 85:1954-1962.
26. Jo, Y.H., Wiedl, D., Role, L.W. (2005) Cholinergic modulation of appetite-related synapses in mouse lateral hypothalamic slice. J Neurosci, 25:11133-11144.
27. Janka, Z., Somogyi, A., Magloczky, E., Pakaski, M., Kalman, J. (1988) Dementia screening by a short cognitive test. Orv Hetil, 129:2797-800.
28. Kadowaki, T., Yamauchi, T. (2005) Adiponectin and adiponectin receptors. Endocr Rev, 26:439-451.
29. Kalman, J., Janka, Z. (2005) Cholesterol and Alzheimer's disease. Orv Hetil 146:1903-1911.
30. Kalman, J., Juhasz, A., Laird, G., Dickens, P., Jardanhazy, T., Rimanoczy, A., Boncz, I., Parry-Jones, W.L., Janka, Z. (1997) Serum interleukin-6 levels correlate with the severity of dementia in Down syndrome and in Alzheimer's disease. Acta Neurol Scand, 96:236-240.
31. Kalman, J., Magloczky, E., Janka, Z. (1995) Disturbed visuospatial orientation in the early stage of Alzheimer's dementia. Arch Gerontol Geriatr, 21:27-34.
32. Kershaw, E.E., Flier, J.S. (2004) Adipose tissue as an endocrine organ. J Clin Endocrinol Metab, 89:2548-2556.
33. Kivipelto, M., Ngandu, T., Fratiglioni, L., Viitanen, M., Kareholt, I., Winblad, B., Helkala, E.L., Tuomilehto, J., Soininen, H., Nissinen, A. (2005) Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Arch Neurol, 62:1556-1560.
34. Kruger, I.M., Huisman, H.W., Schutte, A.E. (2011) The relationship between adiponectin, ageing and renal function in a bi-ethnic sample. Regul Pept, 169:58-63.
35. Li, D.L., Liu, J.J., Liu, B.H., Hu, H., Sun, L., Miao, Y., Xu, H.F., Yu, X.J., Ma, X., Ren, J., Zang, W.J. (2011) Acetylcholine inhibits hypoxia-induced tumor necrosis factor-α production via regulation of MAPKs phosphorylation in cardiomyocytes. J Cell Physiol 226:1052-1059.
36. Lieb, W., Beiser, A.S., Vasan, R.S., Tan, Z.S., Au, R., Harris, T.B., Roubenoff, R., Auerbach, S., DeCarli, C., Wolf, P.A., Seshadri, S. (2009) Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging. JAMA, 302: 2565-2572.
37. Lu, X.Y. (2007) The leptin hypothesis of depression: a potential link between mood disorders and obesity. Curr Opin Pharmacol, 7:648-652.
38. Marwarha, G., Dasari, B., Prasanthi, J.R., Schommer, J., Ghribi, O. (2010) Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. J Alzheimers Dis, 19:1007-1019.
39. Mohs, R.C., Doody, R.S., Morris, J.C., Ieni, J.R., Rogers, S.L., Perdomo, C.A., Pratt, R.D. (2001) "312" Study Group. A 1-year, placebo-controlled preservation of function survival study of donepezil in AD patients. Neurology, 57:481-488.
40. Miyata, G., Meguid, M.M., Fetissov, S.O., Torelli, G.F., Kim, H.J. (1999) Nicotine's effect on hypothalamic neurotransmitters and appetite regulation. Surgery, 126:255-263.
41. Miyata, G., Meguid, M.M., Varma, M., Fetissov, S.O., Kim, H.J. (2001) Nicotine alters the usual reciprocity between meal size and meal number in female rat. Physiol Behav, 74:169-176.
42. Monllau, A., Pena-Casanova, J., Blesa, R., Aguilar, M., Bohm, P., Sol, J.M., Hernandez, G. (2007 Oct;22) Diagnostic value and functional correlations of the ADAS-Cog scale in Alzheimer's disease: data on NORMACODEM project. Neurologia, (8):493-501.
43. Nicklas, B.J., Tomoyasu, N., Muir, J., Goldberg, A.P. (1999) Effects of cigarette smoking and its cessation on body weight and plasma leptin levels. Metabolism, 48:804-808.
44. Nourhashemi, F., Deschamps, V., Larrieu, S., Letenneur, L., Dartigues, J.F., Barberger-Gateau, P. (2003) Body mass index and incidence of dementia: The PAQUID study. Neurology, 60:117-119.
45. Oomura, Y., Hori, N., Shiraishi, T., Fukunaga, K., Takeda, H., Tsuji, M., Matsumiya, T., Ishibashi, M., Aou, S., Li, X.L., Kohno, D., Uramura, K., Sougawa, H., Yada, T., Wayner, M.J., Sasaki, K. (2006) Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats. Peptides, 27:2738-2749.
46. Perez-Gonzalez, R., Antequera, D., Vargas, T., Spuch, C., Bolos, M., Carro, E. (2011) Leptin induces proliferation of neuronal progenitors and neuroprotection in a mouse model of Alzheimer's disease. J Alzheimers Dis, 24S:17-25.
47. Phillips, L.K., Prins, J.B. (2008) The link between abdominal obesity and the metabolic syndrome. Curr Hypertens Rep, 10:156-164.
48. Psilopanagioti, A., Papadaki, H., Kranioti, E.F., Alexandrides, T.K., Varakis, J.N. (2009) Expression of adiponectin and adiponectin receptor sin human pituitary gland and brain. Neuroendocrinology 89:38-47.
49. Ritchie, K., Lovestone, S. (2002) The dementias. Lancet, 360:1759-1766.
50. Rosen, W.G., Mohs, R.C., Davis, K.L. (1984) A new rating scale for Alzheimer's disease. Am J Psychiatry,141:1356-1364.
51. Rosenbaum, M., Nicolson, M., Hirsch, J., Heymsfield, S.B., Gallagher, D., Chu, F., Leibel, R.L. (1996) Effects of gender, body composition, and menopause on plasma concentration of leptin. J Clin Endocrinol Metab, 81:3424-3427.
52. Sanford, A., Charles D.C., Philip A. W., Sudha S. (2009 December 16) Association of Plasma Leptin Levels with Incident Alzheimer's Disease and MRI Measures Of Brain Aging: The Framingham Study JAMA, 302(23): 2565-2572.
53. Shanley, L.J., Irving, A.J., Rae, M.G., Ashford, M.L., Harvey, J. (2002) Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels. Nat Neurosci, 5:299-300.
54. Sierra-Honigmann, M.R., Nath, A.K., Murakami, C., Garcia- Cardena, G., Papapetropoulos, A., Sessa, W.C., Madge, L.A., Schechner, J.S., Schwabb, M.B., Polverini, P.J., Flores-Riveros, J.R. (1998) Biological action of leptin as an angiogenic factor. Science, 281:1683-1686.
55. Spranger, J., Verma, S., Gohring, I., Bobbert, T., Seifert, J., Sindler, A.L., Pfeiffer, A., Hileman, S.M., Tschop, M., Banks, W.A. (2006) Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells. Diabetes, 55;141-147.
56. Tsao, T.S., Lodish, H.F., Fruebis, J. (2002) ACRP30, a new hormone controlling fat and glucose metabolism. Eur J Pharmacol, 440:213-221.
57. Une, K., Takei, Y.A., Tomita, N., Asamura, T., Ohrui, T., Furukawa, K., Arai, H. (2010) Adiponectin in plasma and cerebrospinal fluid in MCI and Alzheimer's disease. Eur J Neurol, 18:1006-1009.
58. Wei, M., Stern, M.P., Haffner, S.M. (1997) Serum leptin levels in Mexican Americans and non-Hispanic whites: association with body mass index and cigarette smoking. Ann Epidemiol, 7:81-86.
59. Whitmer, R.A., Gunderson, E.P., Barrett-Connor, E., Quesenberry, C.P. Jr., Yaffe, K. (2005) Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study. BMJ, 330:1360-1365.
60. Wiêcek, A., Adamczak, M., Chudek, J. (2007) Adiponectin - an adipokine with unique metabolic properties. Nephrol Dial Transplant, 22, 981-988.
61. Wong, M.L., Licinio, J., Yildiz, B.O., Mantzoros, C.S., Prolo, P., Kling, M., Gold, P.W. (2004) Simultaneous and continuous 24-hour plasma and cerebrospinal fluid leptin measurements: dissociation of concentrations in central and peripheral compartments J Clin Endocrinol Metab, 89:258-265.
62. Yu, Y.H., Ginsberg, H.N. (2005) Adipocyte signaling and lipid homeostasis: sequelae of insulin-resistant adipose tissue. Circ Res, 96:1042-1052.
63. Zhang, F., Wang, S., Signore, A.P., Chen, J. (2007) Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia. Stroke, 38:2329-2336.
64. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., Friedman, J.L. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432.
65. Zou, C., Shao, J. (2008) Role of adipocytokines in obesity-associated insulin resistance. J Nutr Biochem, 19:277-286.