Serum interleukin-6 levels correlate with the severity of dementia in down syndrome and in Alzheimer's disease

Acta Neurologica Scandinavica

Volumn 96, Issue 4, 1997, Pages 236-240

  Kalman J ^a   Juhasz A ^a   Laird, G ^b   Dickens, P ^c   Jardanhazy T ^a   Rimanoczy A ^a   Boncz, I ^a   Parry Jones, W L I ^d   Janka, Z ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b Lennox Castle Hospital   (United Kingdom)

^c Royal Scottish National Hospital   (United Kingdom)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Alzheimer's disease; Cerebrospinal fluid; Dementia; Down syndrome; Interleukin 6; Serum

Indexed keywords

INTERLEUKIN 6;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BLOOD ANALYSIS; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; DEMENTIA; DISEASE SEVERITY; DOWN SYNDROME; FEMALE; HUMAN; MALE;

EID: 0030855888     PISSN: 00016314     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0404.1997.tb00275.x     Document Type: Article

References (35)

1. SHERRINGTON R, ROGAEV EI, LIANG Y et al. Cloning of a novel gene bearing missense mutations in early onset familial Alzheimer disease. Nature 1995: 375: 754-60.
2. LEVY-LAHAD E, WASCO W, POOKAJ P et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 1995: 269: 973-7.
3. ROGAEV EI, SHERRINGTON R, ROGAEVA EA et al. Familial Alzheimer's disease in kindreds with missense mutation in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 1975: 376: 775-8.
4. LEVY E, CARMAN MD, FERNANDEZ-MADRID IJ et al. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science 1990: 248: 1124-6.
5. GOATHE A, CHARTIER-HARLIN M, MULLAN M et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991: 349: 704-6.
6. TANZI RE, GUSELLA JE, WATKINS P et al. Amyloid beta-protein gene cDNA, mRNA distribution and genetic linkage near the Alzheimer locus. Science 1987: 235: 880-4.
7. WISNIEWSKI HM, RABE A. Discrepancy between Alzheimer-type neuropathology and dementia in persons with Down's syndrome. Ann NY Acad Sci 1985: 477: 247-60.
8. CORK LC. Neuropathology of Down syndrome and Alzheimer disease. Am J Med Genet Suppl 1990: 7: 282-6.
9. BERKENBOSCH F, BIEWENGA J, BROUNS M, ROZEMULLER JM, STRIJBOS P, VAN DAM AM. Cytokines and inflammatory proteins in Alzheimer's disease. Res Immunol 1993: 143: 657-63.
10. LICASTRO F, PARNETTI L, MORINI MC et al. Acute phase reactant alfa-1-antichymotrypsin is increased in cerebrospinal fluid and serum of patients with probable Alzheimer disease. Alzheimer Dis Assoc Disord 1995: 2: 112-18.
11. MCGEER PL, AKIYAMA H, ITAGAKI S, MCGEER EG. Activation of the classical complement pathway in brain tissue of Alzheimer patients. Neurosci Lett 1989: 107: 341-6.
12. AKIYAMA H, KAWAMATA T, DEDHAR S, MCGEER PL. Immunohistochemical localization of vitronectin, its receptor and beta-3 integrin in Alzheimer brain tissue. J Neuroimmunol 1991: 32: 19-28.
13. MAY PC, LAMPERT-ETCHELLS M, JOHNSON SA, POIRIER J, MASTERS JN, FINCH CE. Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat. Neuron 1990: 5: 831-9.
14. SATOH T, NAKAMURA S, TAGA T et al. Induction of neuronal differentation in PC12 cells by B-cell stimulatory factor 2/ interleukin 6. Mol Cell Biol 1988: 8: 3546-9.
15. CAMPBELL IL, ABRAHAM CR, MASLIAH E et al. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin-6. Proc Natl Acad Sci USA 1993: 90: 10061-5.
16. DEL BO RD, ANGERETTI N, LUCCA E, DE-SIMONI MG, FORLONI G. Reciprocal control of inflammatory cytokines, IL-1, and IL-6, and beta-amyloid production in cultures. Neurosci Lett 1995: 188: 70-4.
17. BRUGG B, DUBREUIL LY, HUBER G, WOLLMAN EE, DELHAYE BM, MARIANI J. Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain. Proc Natl Acad Sci USA, 1995: 92: 3032-5.
18. DE VRIES HE, BLOM-ROOSEMALEN MCM, VAN OOSTEN M et al. The influence of cytokines on the integrity of the blood-brain barrier in vitro. J Neuroimmunol 1996: 64: 37-43.
19. NIHIRA K, FOSTER R, SHELLHAAS M, LELAND H. AAMD Adaptive Behavior Scale, 1974 revision. Washington DC: American Association on Mental Deficiency.
20. SCHAPIRO MB, HAXBY JB, GRADY CL et al. Decline in cerebral glucose utilisation and cognitive function with aging in Down's syndrome. J Neurol Neurosurg Psychiatry 1987: 50: 766-74.
21. MCKHANN G, DRACHMAN D, FOLSTEIN M et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group. Neurology 1984: 34: 939-44.
22. American Psychiatric Association (APA): Diagnostic and Statistical Manual of Mental Disorders, ed 3, revised, Washington DC: American Psychiatric Association, 1987.
23. FOLSTEIN MF, FOLSTEIN ME, MCHUGH PR. Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiat Res 1975: 12: 189-98.
24. VAN DUIJN CM, HOFMAN A, NAGELKERKEN L. Serum levels of interleukin-6 are not elevated in patients with Alzheimer's disease. Neurosci Lett 1990: 108: 350-4.
25. BAUER J, STRAUSS S, SCHREITLER-GASSER U et al. Interleukin-6 and alfa-2 macroglobulin indicate an acute-phase state in Alzheimer's disease cortices. FEBS Lett 1991: 285: 111-14.
26. YAMADA K, KONO K, UMEGAKI H et al. Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer's-type of dementia. Neurosci Lett 1995: 186: 219-21.
27. HUBERMAN M, SHALIT F, ROTH-DERI I et al. Correlation of cytokine secretion by mononuclear cells of Alzheimer patients and their disease stage. J Neuroimmunol 1994: 52: 147-52.
28. HUBERMAN M, SREDNI B, STERN L, KOTT E, SHALIF F. IL-2 and IL-6 secretion in dementia: correlation with type and severity of disease. J Neurol Sci 1995: 130: 161-4.
29. VANDENABEELE P, FIERS W. Is amyloidogenesis during Alzheimer's disease due to an IL-1/IL-6-mediated "acute phase response" in the brain? Immunol Today 1991: 217: 217-19.
30. ABRAHAM CR. The role of acute-phase proteins alfa-1-antichymotrypsin in brain dysfunction and injury. Res Immunol 1992: 143: 631-6.
31. ERSCHLER WB. Interleukin-6: a cytokine for gerontologist. J Am Geratr Soc 1993: 41: 176-81.
32. PIRTILLA T, MEHTA PD, FREY H, WISNIEWSKI HM. Alfa-1-antichymotrypsin and IL-1 beta are not increased in CSF or serum in Alzheimer's disease. Neurobiol Aging 1994: 15: 313-17.
33. LAWLOR BA, SWANWICK GRJ, FEIGHERY C, WALSH JB, COAKLEY D. Acute phase reactants in Alzheimer's disease. Biol Psychiatry 1996: 39: 1051-2.
34. MCRAE A, DAHLSTROM A. Immune responses in brains of Alzheimer's and Parkinson's disease patients: hypothesis and reality. Rev Neurosci 1992: 3: 79-97.
35. PERLMUTTER LS, BARROW E, CHUI HC. Microangiopathy, the vascular basement membrane and Alzheimer's disease: a review. Brain Res Bull 1990: 24: 677-86.