Chaeoglobosin Fex inhibits poly(I:C)-induced activation of bone marrow-derived dendritic cells

Molecular Immunology

Volumn 51, Issue 2, 2012, Pages 150-158

  Sun, Lin ^a   Hua, Chunyan ^a   Yang, Yonghong ^a   Dou, Huan ^a   Li, Erguang ^a   Tan, Renxiang ^a   Hou, Yayi ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

BMDCs; Chaeoglobosin Fex; IFN ; Maturation; TLR3 signaling

Indexed keywords

ALKALOID; ANTIGEN; BETA INTERFERON; CHAEOGLOBOSIN FEX; I KAPPA B ALPHA; INTERFERON REGULATORY FACTOR 3; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; POLYINOSINIC POLYCYTIDYLIC ACID; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL FUNCTION; CELL MATURATION; CHAETOMIUM; CHAETOMIUM GLOBOSUM; CONTROLLED STUDY; DENDRITIC CELL; ENDOCYTOSIS; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ALKALOIDS; ANIMALS; BLOTTING, WESTERN; BONE MARROW CELLS; CELL SURVIVAL; CHAETOMIUM; DENDRITIC CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; INTERFERON-BETA; LYMPHOCYTE CULTURE TEST, MIXED; MICE; MICE, INBRED C57BL; POLY I-C; REAL-TIME POLYMERASE CHAIN REACTION; TOLL-LIKE RECEPTOR 3;

CHAETOMIUM GLOBOSUM; FUNGI;

EID: 84862816076     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2012.02.125     Document Type: Article

References (38)

1. Akira S., Uematsu S., Takeuchi O. Pathogen recognition and innate immunity. Cell 2006, 124:783-801.
2. Alexopoulou L., Holt A.C., Medzhitov R., Flavell R.A. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001, 413:732-738.
3. Bennett C.L., Chakraverty R. Dendritic cells in tissues: in situ stimulation of immunity and immunopathology. Trends Immunol. 2011.
4. Boes M., Cuvillier A., Ploegh H. Membrane specializations and endosome maturation in dendritic cells and B cells. Trends Cell Biol. 2004, 14:175-183.
5. Brown J., Wang H., Hajishengallis G.N., Martin M. TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. J. Dent. Res. 2011, 90:417-427.
6. Capini C., Jaturanpinyo M., Chang H.I., Mutalik S., McNally A., Street S., Steptoe R., O'Sullivan B., Davies N., Thomas R. Antigen-specific suppression of inflammatory arthritis using liposomes. J. Immunol. 2009, 182:3365-3556.
7. Dou H., Song Y., Liu X., Gong W., Li E., Tan R., Hou Y. Chaetoglobosin Fex from the marine-derived endophytic fungus inhibits induction of inflammatory mediators via toll-like receptor 4 signaling in macrophages. Biol. Pharm. Bull. 2011, 34:1864-1873.
8. Du S., Sandoval F., Trinh P., Umeda E., Voskuhl R. Estrogen receptor-beta ligand treatment modulates dendritic cells in the target organ during autoimmune demyelinating disease. Eur. J. Immunol. 2011, 41:140-150.
9. Gauzzi M.C., Del Corno M., Gessani S. Dissecting TLR3 signalling in dendritic cells. Immunobiology 2010, 215:713-723.
10. Gowen B.B., Hoopes J.D., Wong M.H., Jung K.H., Isakson K.C., Alexopoulou L., Flavell R.A., Sidwell R.W. TLR3 deletion limits mortality and disease severity due to Phlebovirus infection. J. Immunol. 2006, 177:6301-6307.
11. Hoebe K., Janssen E.M., Kim S.O., Alexopoulou L., Flavell R.A., Han J., Beutler B. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat. Immunol. 2003, 4:1223-1229.
12. Hutchens M., Luker K.E., Sottile P., Sonstein J., Lukacs N.W., Nunez G., Curtis J.L., Luker G.D. TLR3 increases disease morbidity and mortality from vaccinia infection. J. Immunol. 2008, 180:483-491.
13. Itoh K., Watanabe A., Funami K., Seya T., Matsumoto M. The clathrin-mediated endocytic pathway participates in dsRNA-induced IFN-beta production. J. Immunol. 2008, 181:5522-5529.
14. Jeong E., Lee J.Y. Intrinsic and extrinsic regulation of innate immune receptors. Yonsei Med. J. 2011, 52:379-392.
15. Jones L.A., Kreem S., Shweash M., Paul A., Alexander J., Roberts C.W. Differential modulation of TLR3- and TLR4-mediated dendritic cell maturation and function by progesterone. J. Immunol. 2010, 185:4525-4534.
16. Kato M., Neil T.K., Fearnley D.B., McLellan A.D., Vuckovic S., Hart D.N. Expression of multilectin receptors and comparative FITC-dextran uptake by human dendritic cells. Int. Immunol. 2000, 12:1511-1519.
17. Kawai T., Akira S. Innate immune recognition of viral infection. Nat. Immunol. 2006, 7:131-137.
18. Kawai T., Akira S. The roles of TLRs, RLRs and NLRs in pathogen recognition. Int. Immunol. 2009, 21:317-337.
19. Lee M.S., Kim Y.J. Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu. Rev. Biochem 2007, 76:447-480.
20. Li N., Li Q., Qian Z., Zhang Y., Chen M., Shi G. Impaired TLR3/IFN-beta signaling in monocyte-derived dendritic cells from patients with acute-on-chronic hepatitis B liver failure: relevance to the severity of liver damage. Biochem. Biophys. Res. Commun. 2009, 390:630-635.
21. Lipscomb M.F., Masten B.J. Dendritic cells: immune regulators in health and disease. Physiol. Rev. 2002, 82:97-130.
22. Matesic D.F., Villio K.N., Folse S.L., Garcia E.L., Cutler S.J., Cutler H.G. Inhibition of cytokinesis and Akt phosphorylation by chaetoglobosin K in ras-transformed epithelial cells. Cancer Chemother. Pharmacol. 2006, 57:741-754.
23. Matsumoto M., Oshiumi H., Seya T. Antiviral responses induced by the TLR3 pathway. Rev. Med. Virol. 2011.
24. Merad M., Manz M.G. Dendritic cell homeostasis. Blood 2009, 113:3418-3427.
25. Nguyen-Pham T.N., Lim M.S., Nguyen T.A., Lee Y.K., Jin C.J., Lee H.J., Hong C.Y., Ahn J.S., Yang D.H., Kim Y.K., Chung I.J., Park B.C., Kim H.J., Lee J.J. Type I and II interferons enhance dendritic cell maturation and migration capacity by regulating CD38 and CD74 that have synergistic effects with TLR agonists. Cell. Mol. Immunol. 2011, 8:341-347.
26. O'Sullivan B.J., Pai S., Street S., An X., MacDonald K.P., Wong M., Strutton G., Gerondakis S., Steptoe R.J., de St Groth B.F., Hill G.R., Thomas R. Immunotherapy with costimulatory dendritic cells to control autoimmune inflammation. J. Immunol. 2011, 187:4018-4030.
27. Plotnikov A., Zehorai E., Procaccia S., Seger R. The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. Biochim. Biophys. Acta 2011, 1813:1619-1633.
28. Proietto A.I., van Dommelen S., Zhou P., Rizzitelli A., D'Amico A., Steptoe R.J., Naik S.H., Lahoud M.H., Liu Y., Zheng P., Shortman K., Wu L. Dendritic cells in the thymus contribute to T-regulatory cell induction. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:19869-19874.
29. Qian C., An H., Yu Y., Liu S., Cao X. TLR agonists induce regulatory dendritic cells to recruit Th1 cells via preferential IP-10 secretion and inhibit Th1 proliferation. Blood 2007, 109:3308-3315.
30. Reis e Sousa C. Toll-like receptors and dendritic cells: for whom the bug tolls. Semin. Immunol. 2004, 16:27-34.
31. Schakel K. Dendritic cells-why can they help and hurt us. Exp. Dermatol. 2009, 18:264-273.
32. Sidorova T.S., Matesic D.F. Protective effect of the natural product, chaetoglobosin K, on lindane- and dieldrin-induced changes in astroglia: identification of activated signaling pathways. Pharm. Res. 2008, 25:1297-1308.
33. Steinman R.M., Banchereau J. Taking dendritic cells into medicine. Nature 2007, 449:419-426.
34. Theofilopoulos A.N., Baccala R., Beutler B., Kono D.H. Type I interferons (alpha/beta) in immunity and autoimmunity. Annu. Rev. Immunol. 2005, 23:307-336.
35. Warger T., Osterloh P., Rechtsteiner G., Fassbender M., Heib V., Schmid B., Schmitt E., Schild H., Radsak M.P. Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo. Blood 2006, 108:544-550.
36. Wilson N.S., Behrens G.M., Lundie R.J., Smith C.M., Waithman J., Young L., Forehan S.P., Mount A., Steptoe R.J., Shortman K.D., de Koning-Ward T.F., Belz G.T., Carbone F.R., Crabb B.S., Heath W.R., Villadangos J.A. Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity. Nat. Immunol. 2006, 7:165-172.
37. Winzler C., Rovere P., Rescigno M., Granucci F., Penna G., Adorini L., Zimmermann V.S., Davoust J., Ricciardi-Castagnoli P. Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures. J. Exp. Med. 1997, 185:317-328.
38. Xie H., Hua C., Sun L., Zhao X., Fan H., Dou H., Hou Y. 17beta-estradiol induces CD40 expression in dendritic cells via MAPK signaling pathways in a minichromosome maintenance protein 6-dependent manner. Arthritis Rheum. 2011, 63:2425-2435.