메뉴 건너뛰기




Volumn 185, Issue 8, 2010, Pages 4525-4534

Differential modulation of TLR3-and TLR4-mediated dendritic cell maturation and function by progesterone

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 12; INTERLEUKIN 6; NORGESTREL; PROGESTERONE; PROGESTERONE RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; CYTOKINE; TLR3 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE;

EID: 78049489352     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901155     Document Type: Article
Times cited : (79)

References (57)
  • 1
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392:245-252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 3
    • 0041402775 scopus 로고    scopus 로고
    • Shaping the immune response to parasites: Role of dendritic cells
    • Sher, A., E. Pearce, and P. Kaye. 2003. Shaping the immune response to parasites: role of dendritic cells. Curr. Opin. Immunol. 15:421-429.
    • (2003) Curr. Opin. Immunol. , vol.15 , pp. 421-429
    • Sher, A.1    Pearce, E.2    Kaye, P.3
  • 4
    • 0030791019 scopus 로고    scopus 로고
    • The role of dendritic cells in T cell activation
    • Ni, K., and H. C. O'Neill. 1997. The role of dendritic cells in T cell activation. Immunol. Cell Biol. 75:223-230.
    • (1997) Immunol. Cell. Biol. , vol.75 , pp. 223-230
    • Ni, K.1    O'Neill, H.C.2
  • 6
    • 0033970345 scopus 로고    scopus 로고
    • Role of hormone-controlled T-cell cytokines in the maintenance of pregnancy
    • Piccinni, M.-P., E. Maggi, and S. Romagnani. 2000. Role of hormone-controlled T-cell cytokines in the maintenance of pregnancy. Biochem. Soc. Trans. 28:212-215.
    • (2000) Biochem. Soc. Trans. , vol.28 , pp. 212-215
    • Piccinni, M.-P.1    Maggi, E.2    Romagnani, S.3
  • 7
    • 38449108331 scopus 로고    scopus 로고
    • Cytokine imbalance in pregnancy complications and its modulation
    • Raghupathy, R., and J. Kalinka. 2008. Cytokine imbalance in pregnancy complications and its modulation. Front. Biosci. 13:985-994.
    • (2008) Front. Biosci. , vol.13 , pp. 985-994
    • Raghupathy, R.1    Kalinka, J.2
  • 8
    • 36048968893 scopus 로고    scopus 로고
    • T cell recognition and immunity in the fetus and mother
    • Koch, C. A., and J. L. Platt. 2007. T cell recognition and immunity in the fetus and mother. Cell. Immunol. 248:12-17.
    • (2007) Cell. Immunol. , vol.248 , pp. 12-17
    • Koch, C.A.1    Platt, J.L.2
  • 9
    • 38449123648 scopus 로고    scopus 로고
    • The role of T-regulatory cells in pregnancy and cancer
    • Wilczynski, J. R., J. Kalinka, and M. Radwan. 2008. The role of T-regulatory cells in pregnancy and cancer. Front. Biosci. 13:2275-2289.
    • (2008) Front. Biosci. , vol.13 , pp. 2275-2289
    • Wilczynski, J.R.1    Kalinka, J.2    Radwan, M.3
  • 10
    • 42949123405 scopus 로고    scopus 로고
    • Altered dendritic cell function in normal pregnancy
    • Bachy, V., D. J. Williams, and M. A. Ibrahim. 2008. Altered dendritic cell function in normal pregnancy. J. Reprod. Immunol. 78:11-21.
    • (2008) J. Reprod. Immunol. , vol.78 , pp. 11-21
    • Bachy, V.1    Williams, D.J.2    Ibrahim, M.A.3
  • 11
    • 50049096558 scopus 로고    scopus 로고
    • Role of dendritic cells in the regulation of maternal immune responses to the fetus during mammalian gestation
    • Kammerer, U., A. Kruse, G. Barrientos, P. C. Arck, and S. M. Blois. 2008. Role of dendritic cells in the regulation of maternal immune responses to the fetus during mammalian gestation. Immunol. Invest. 37:499-533.
    • (2008) Immunol. Invest. , vol.37 , pp. 499-533
    • Kammerer, U.1    Kruse, A.2    Barrientos, G.3    Arck, P.C.4    Blois, S.M.5
  • 14
    • 0142124417 scopus 로고    scopus 로고
    • Regulation of innate and adaptive immunity by the female sex hormones oestradiol and progesterone
    • Beagley, K. W., and C. M. Gockel. 2003. Regulation of innate and adaptive immunity by the female sex hormones oestradiol and progesterone. FEMS Immunol. Med. Microbiol. 38:13-22.
    • (2003) FEMS Immunol. Med. Microbiol. , vol.38 , pp. 13-22
    • Beagley, K.W.1    Gockel, C.M.2
  • 15
    • 34548331157 scopus 로고    scopus 로고
    • Regulation of dendritic cells by female sex steroids: Relevance to immunity and autoimmunity
    • Hughes, G. C., and E. A. Clark. 2007. Regulation of dendritic cells by female sex steroids: relevance to immunity and autoimmunity. Autoimmunity 40:470-481.
    • (2007) Autoimmunity , vol.40 , pp. 470-481
    • Hughes, G.C.1    Clark, E.A.2
  • 16
    • 0027397405 scopus 로고
    • Inhibition by glucocorticoids of the formation of interleukin-1 a, interleukin-1 β, and interleukin-6: Mediation by decreased mRNA stability
    • Amano, Y., S. W. Lee, and A. C. Allison. 1993. Inhibition by glucocorticoids of the formation of interleukin-1 a, interleukin-1 β, and interleukin-6: mediation by decreased mRNA stability. Mol. Pharmacol. 43:176-182.
    • (1993) Mol. Pharmacol. , vol.43 , pp. 176-182
    • Amano, Y.1    Lee, S.W.2    Allison, A.C.3
  • 17
  • 18
    • 19544368786 scopus 로고    scopus 로고
    • Dexamethasone selectively inhibits differentiation of cord blood stem cell derived-dendritic cell (DC) precursors into immature DCs
    • Mainali, E. S., and J. G. Tew. 2004. Dexamethasone selectively inhibits differentiation of cord blood stem cell derived-dendritic cell (DC) precursors into immature DCs. Cell. Immunol. 232:127-136.
    • (2004) Cell. Immunol. , vol.232 , pp. 127-136
    • Mainali, E.S.1    Tew, J.G.2
  • 19
    • 0033998582 scopus 로고    scopus 로고
    • Differential effects of corticosteroids during different stages of dendritic cell maturation
    • Matyszak, M. K., S. Citterio, M. Rescigno, and P. Ricciardi-Castagnoli. 2000. Differential effects of corticosteroids during different stages of dendritic cell maturation. Eur. J. Immunol. 30:1233-1242.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 1233-1242
    • Matyszak, M.K.1    Citterio, S.2    Rescigno, M.3    Ricciardi-Castagnoli, P.4
  • 20
    • 0035794989 scopus 로고    scopus 로고
    • Dexamethasone inhibits the antigen presentation of dendritic cells in MHC class II pathway
    • Pan, J., D. Ju, Q. Wang, M. Zhang, D. Xia, L. Zhang, H. Yu, and X. Cao. 2001. Dexamethasone inhibits the antigen presentation of dendritic cells in MHC class II pathway. Immunol. Lett. 76:153-161.
    • (2001) Immunol. Lett. , vol.76 , pp. 153-161
    • Pan, J.1    Ju, D.2    Wang, Q.3    Zhang, M.4    Xia, D.5    Zhang, L.6    Yu, H.7    Cao, X.8
  • 22
    • 18244397482 scopus 로고    scopus 로고
    • Molecular mechanisms of glucocorticoids in the control of inflammation and lymphocyte apoptosis
    • Tuckermann, J. P., A. Kleiman, K. G. McPherson, and H. M. Reichardt. 2005. Molecular mechanisms of glucocorticoids in the control of inflammation and lymphocyte apoptosis. Crit. Rev. Clin. Lab. Sci. 42:71-104.
    • (2005) Crit. Rev. Clin. Lab. Sci. , vol.42 , pp. 71-104
    • Tuckermann, J.P.1    Kleiman, A.2    McPherson, K.G.3    Reichardt, H.M.4
  • 23
    • 24644506268 scopus 로고    scopus 로고
    • Pregnancy associated hormones modulate the cytokine production but not the phenotype of PBMC-derived human dendritic cells
    • Huck, B., T. Steck, M. Habersack, J. Dietl, and U. Kämmerer. 2005. Pregnancy associated hormones modulate the cytokine production but not the phenotype of PBMC-derived human dendritic cells. Eur. J. Obstet. Gynecol. Reprod. Biol. 122:85-94.
    • (2005) Eur. J. Obstet. Gynecol. Reprod. Biol. , vol.122 , pp. 85-94
    • Huck, B.1    Steck, T.2    Habersack, M.3    Dietl, J.4    Kämmerer, U.5
  • 24
    • 33645022627 scopus 로고    scopus 로고
    • Progesterone regulates mouse dendritic cells differentiation and maturation
    • Liang, J., L. Sun, Q. Wang, and Y. Hou. 2006. Progesterone regulates mouse dendritic cells differentiation and maturation. Int. Immunopharmacol. 6:830-838.
    • (2006) Int. Immunopharmacol , vol.6 , pp. 830-838
    • Liang, J.1    Sun, L.2    Wang, Q.3    Hou, Y.4
  • 25
    • 33747836277 scopus 로고    scopus 로고
    • Progesterone is involved in the maturation of murine spleen CD11c-positive dendritic cells
    • DOI 10.1016/j.steroids.2006.07.001, PII S0039128X0600170X
    • Yang, L., X. Li, J. Zhao, and Y. Hou. 2006. Progesterone is involved in the maturation of murine spleen CD11c-positive dendritic cells. Steroids 71:922-929. (Pubitemid 44286963)
    • (2006) Steroids , vol.71 , Issue.10 , pp. 922-929
    • Yang, L.1    Li, X.2    Zhao, J.3    Hou, Y.4
  • 26
    • 49249122123 scopus 로고    scopus 로고
    • Toll-like receptor-4-mediated macrophage activation is differentially regulated by progesterone via the glucocorticoid and progesterone receptors
    • Jones, L. A., J. P. Anthony, F. L. Henriquez, R. E. Lyons, M. B. Nickdel, K. C. Carter, J. Alexander, and C. W. Roberts. 2008. Toll-like receptor-4-mediated macrophage activation is differentially regulated by progesterone via the glucocorticoid and progesterone receptors. Immunology 125:59-69.
    • (2008) Immunology , vol.125 , pp. 59-69
    • Jones, L.A.1    Anthony, J.P.2    Henriquez, F.L.3    Lyons, R.E.4    Nickdel, M.B.5    Carter, K.C.6    Alexander, J.7    Roberts, C.W.8
  • 27
    • 0033012030 scopus 로고    scopus 로고
    • An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
    • Lutz, M. B., N. Kukutsch, A. L. J. Ogilvie, S. Rössner, F. Koch, N. Romani, and G. Schuler. 1999. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 223:77-92.
    • (1999) J. Immunol. Methods , vol.223 , pp. 77-92
    • Lutz, M.B.1    Kukutsch, N.2    Ogilvie, A.L.J.3    Rössner, S.4    Koch, F.5    Romani, N.6    Schuler, G.7
  • 28
    • 13844276556 scopus 로고    scopus 로고
    • Development of colorimetric microtiter plate assay for assessment of antimicrobials against Acanthamoeba
    • McBride, J., P. R. Ingram, F. L. Henriquez, and C. W. Roberts. 2005. Development of colorimetric microtiter plate assay for assessment of antimicrobials against Acanthamoeba. J. Clin. Microbiol. 43:629-634.
    • (2005) J. Clin. Microbiol. , vol.43 , pp. 629-634
    • McBride, J.1    Ingram, P.R.2    Henriquez, F.L.3    Roberts, C.W.4
  • 29
    • 33845361558 scopus 로고    scopus 로고
    • IKKalpha and IKKbeta function in TNFalpha-stimulated adhesion molecule expression in human aortic smooth muscle cells
    • MacKenzie, C. J., E. Ritchie, A. Paul, and R. Plevin. 2007. IKKalpha and IKKbeta function in TNFalpha-stimulated adhesion molecule expression in human aortic smooth muscle cells. Cell. Signal. 19:75-80.
    • (2007) Cell. Signal , vol.19 , pp. 75-80
    • MacKenzie, C.J.1    Ritchie, E.2    Paul, A.3    Plevin, R.4
  • 30
    • 0033746497 scopus 로고    scopus 로고
    • Tolerance to the foeto-placental 'graft': Ten ways to support a child for nine months
    • Thellin, O., B. Coumans, W. Zorzi, A. Igout, and E. Heinen. 2000. Tolerance to the foeto-placental 'graft': ten ways to support a child for nine months. Curr. Opin. Immunol. 12:731-737.
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 731-737
    • Thellin, O.1    Coumans, B.2    Zorzi, W.3    Igout, A.4    Heinen, E.5
  • 32
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    • Alexopoulou, L., A. C. Holt, R. Medzhitov, and R. A. Flavell. 2001. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413:732-738.
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 33
    • 0037378718 scopus 로고    scopus 로고
    • Toll-like receptor 3 mediates a more potent antiviral response than Tolllike receptor 4
    • Doyle, S. E., R. O'Connell, S. A. Vaidya, E. K. Chow, K. Yee, and G. Cheng. 2003. Toll-like receptor 3 mediates a more potent antiviral response than Tolllike receptor 4. J. Immunol. 170:3565-3571.
    • (2003) J. Immunol. , vol.170 , pp. 3565-3571
    • Doyle, S.E.1    O'Connell, R.2    Vaidya, S.A.3    Chow, E.K.4    Yee, K.5    Cheng, G.6
  • 37
    • 41649087959 scopus 로고    scopus 로고
    • Hormonal contraception and HIV prevalence in four African countries
    • Leclerc, P. M., N. Dubois-Colas, and M. Garenne. 2008. Hormonal contraception and HIV prevalence in four African countries. Contraception 77:371-376.
    • (2008) Contraception , vol.77 , pp. 371-376
    • Leclerc, P.M.1    Dubois-Colas, N.2    Garenne, M.3
  • 38
    • 49049113539 scopus 로고    scopus 로고
    • Medroxyprogesterone acetate inhibits CD8+ T cell viral-specific effector function and induces herpes simplex virus type 1 reactivation
    • Cherpes, T. L., J. L. Busch, B. S. Sheridan, S. A. Harvey, and R. L. Hendricks. 2008. Medroxyprogesterone acetate inhibits CD8+ T cell viral-specific effector function and induces herpes simplex virus type 1 reactivation. J. Immunol. 181:969-975.
    • (2008) J. Immunol. , vol.181 , pp. 969-975
    • Cherpes, T.L.1    Busch, J.L.2    Sheridan, B.S.3    Harvey, S.A.4    Hendricks, R.L.5
  • 39
    • 42149116947 scopus 로고    scopus 로고
    • Cutting edge: Progesterone regulates IFN-alpha production by plasmacytoid dendritic cells
    • Hughes, G. C., S. Thomas, C. Li, M. K. Kaja, and E. A. Clark. 2008. Cutting edge: progesterone regulates IFN-alpha production by plasmacytoid dendritic cells. J. Immunol. 180:2029-2033.
    • (2008) J. Immunol. , vol.180 , pp. 2029-2033
    • Hughes, G.C.1    Thomas, S.2    Li, C.3    Kaja, M.K.4    Clark, E.A.5
  • 42
    • 30544443971 scopus 로고    scopus 로고
    • 17Beta-estradiol suppresses TLR3-induced cytokine and chemokine production in endometrial epithelial cells
    • Lesmeister, M. J., R. L. Jorgenson, S. L. Young, and M. L. Misfeldt. 2005. 17Beta-estradiol suppresses TLR3-induced cytokine and chemokine production in endometrial epithelial cells. Reprod. Biol. Endocrinol. 3:74.
    • (2005) Reprod. Biol. Endocrinol. , vol.3 , pp. 74
    • Lesmeister, M.J.1    Jorgenson, R.L.2    Young, S.L.3    Misfeldt, M.L.4
  • 43
    • 0037613749 scopus 로고    scopus 로고
    • Progesterone regulates IL12 expression in pregnancy lymphocytes by inhibiting phospholipase A2
    • Par, G., J. Geli, N. Kozma, P. Varga, and J. Szekeres-Bartho. 2003. Progesterone regulates IL12 expression in pregnancy lymphocytes by inhibiting phospholipase A2. Am. J. Reprod. Immunol. 49:1-5.
    • (2003) Am. J. Reprod. Immunol. , vol.49 , pp. 1-5
    • Par, G.1    Geli, J.2    Kozma, N.3    Varga, P.4    Szekeres-Bartho, J.5
  • 44
    • 0020539207 scopus 로고
    • Binding of progestins to the glucocorticoid receptor. Correlation to their glucocorticoid-like effects on in vitro functions of human mononuclear leukocytes
    • Kontula, K., T. Paavonen, T. Luukkainen, and L. C. Andersson. 1983. Binding of progestins to the glucocorticoid receptor. Correlation to their glucocorticoid-like effects on in vitro functions of human mononuclear leukocytes. Biochem. Pharmacol. 32:1511-1518.
    • (1983) Biochem. Pharmacol. , vol.32 , pp. 1511-1518
    • Kontula, K.1    Paavonen, T.2    Luukkainen, T.3    Andersson, L.C.4
  • 45
    • 0002551467 scopus 로고
    • Sex steroids, steroid receptors and immunity
    • I. Berezi, and K. Kovacs, eds. MTP Press, Lancaster, United Kingdom
    • Stimson, W. H. 1986. Sex steroids, steroid receptors and immunity. In Hormones and Immunity. I. Berezi, and K. Kovacs, eds. MTP Press, Lancaster, United Kingdom. p. 93-119.
    • (1986) Hormones and Immunity , pp. 93-119
    • Stimson, W.H.1
  • 46
    • 85047679336 scopus 로고    scopus 로고
    • Progesterone inhibits 20alphahydroxysteroid dehydrogenase expression in the rat corpus luteum through the glucocorticoid receptor
    • Sugino, N., C. M. Telleria, and G. Gibori. 1997. Progesterone inhibits 20alphahydroxysteroid dehydrogenase expression in the rat corpus luteum through the glucocorticoid receptor. Endocrinology 138:4497-4500.
    • (1997) Endocrinology , vol.138 , pp. 4497-4500
    • Sugino, N.1    Telleria, C.M.2    Gibori, G.3
  • 48
    • 0036853620 scopus 로고    scopus 로고
    • Secretion of interleukin-10 or interleukin-12 by LPS-activated dendritic cells is critically dependent on time of stimulus relative to initiation of purified DC culture
    • Jiang, H. R., E. Muckersie, M. Robertson, H. Xu, J. Liversidge, and J. V. Forrester. 2001. Secretion of interleukin-10 or interleukin-12 by LPS-activated dendritic cells is critically dependent on time of stimulus relative to initiation of purified DC culture. J. Leukoc. Biol. 72:978-985.
    • (2001) J. Leukoc. Biol. , vol.72 , pp. 978-985
    • Jiang, H.R.1    Muckersie, E.2    Robertson, M.3    Xu, H.4    Liversidge, J.5    Forrester, J.V.6
  • 49
    • 0033304494 scopus 로고    scopus 로고
    • Molecular control of immune/inflammatory responses: Interactions between nuclear factor-κ B and steroid receptor-signaling pathways
    • McKay, L. I., and J. A. Cidlowski. 1999. Molecular control of immune/inflammatory responses: interactions between nuclear factor-κ B and steroid receptor-signaling pathways. Endocr. Rev. 20:435-459.
    • (1999) Endocr. Rev. , vol.20 , pp. 435-459
    • McKay, L.I.1    Cidlowski, J.A.2
  • 50
    • 0029939162 scopus 로고    scopus 로고
    • Negative interaction between the RelA (p65) subunit of NF-kappaB and the progesterone receptor
    • Kalkhoven, E., S. Wissink, P. T. van der Saag, and B. van der Burg. 1996. Negative interaction between the RelA (p65) subunit of NF-kappaB and the progesterone receptor. J. Biol. Chem. 271:6217-6224.
    • (1996) J. Biol. Chem. , vol.271 , pp. 6217-6224
    • Kalkhoven, E.1    Wissink, S.2    Van Der Saag, P.T.3    Van Der Burg, B.4
  • 52
    • 34548129605 scopus 로고    scopus 로고
    • Convergence of the NF-kappaB and IRF pathways in the regulation of the innate antiviral response
    • Hiscott, J. 2007. Convergence of the NF-kappaB and IRF pathways in the regulation of the innate antiviral response. Cytokine Growth Factor Rev. 18:483-490.
    • (2007) Cytokine Growth Factor Rev. , vol.18 , pp. 483-490
    • Hiscott, J.1
  • 53
    • 33748690758 scopus 로고    scopus 로고
    • Reduced expression of IL-12 p35 by SJL/J macrophages responding to Theiler's virus infection is associated with constitutive activation of IRF-3
    • Dahlberg, A., M. R. Auble, and T. M. Petro. 2006. Reduced expression of IL-12 p35 by SJL/J macrophages responding to Theiler's virus infection is associated with constitutive activation of IRF-3. Virology 353:422-432.
    • (2006) Virology , vol.353 , pp. 422-432
    • Dahlberg, A.1    Auble, M.R.2    Petro, T.M.3
  • 54
    • 30444456366 scopus 로고    scopus 로고
    • The GRIP1: IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression
    • Reily, M. M., C. Pantoja, X. Hu, Y. Chinenov, and I. Rogatsky. 2006. The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression. EMBO J. 25:108-117.
    • (2006) EMBO J. , vol.25 , pp. 108-117
    • Reily, M.M.1    Pantoja, C.2    Hu, X.3    Chinenov, Y.4    Rogatsky, I.5
  • 55
    • 0141891343 scopus 로고    scopus 로고
    • Unfolding the action of progesterone receptors
    • Li, X., and B. W. O'Malley. 2003. Unfolding the action of progesterone receptors. J. Biol. Chem. 278:39261-39264.
    • (2003) J. Biol. Chem. , vol.278 , pp. 39261-39264
    • Li, X.1    O'Malley, B.W.2
  • 57
    • 0032476689 scopus 로고    scopus 로고
    • A nongenomic mechanism for progesterone-mediated immunosuppression: Inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes
    • Ehring, G. R., H. H. Kerschbaum, C. Eder, A. L. Neben, C. M. Fanger, R. M. Khoury, P. A. Negulescu, and M. D. Cahalan. 1998. A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes. J. Exp. Med. 188:1593-1602.
    • (1998) J. Exp. Med. , vol.188 , pp. 1593-1602
    • Ehring, G.R.1    Kerschbaum, H.H.2    Eder, C.3    Neben, A.L.4    Fanger, C.M.5    Khoury, R.M.6    Negulescu, P.A.7    Cahalan, M.D.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.