Amelioration of social isolation-triggered onset of early Alzheimer's disease-related cognitive deficit by N-acetylcysteine in a transgenic mouse model

Neurobiology of Disease

Volumn 45, Issue 3, 2012, Pages 1111-1120

  Hsiao, Ya Hsin ^a   Kuo, Jinn Rung ^b   Chen, Shun Hua ^a   Gean, Po Wu ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b CHI MEI MEDICAL CENTER   (Taiwan)

Author keywords

Alzheimer's disease; Amyloid peptide; Learning and memory; Long term potentiation; N acetylcysteine; Social isolation

Indexed keywords

ACETYLCYSTEINE; ALPHA SECRETASE; AMPA RECEPTOR; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; BETA SECRETASE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALPAIN; CYCLIN DEPENDENT KINASE 5; GAMMA SECRETASE; GLUTAMATE RECEPTOR; PROTEIN KINASE C DELTA; PROTEIN P25; PROTEIN P35; SERINE; SHORT HAIRPIN RNA;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; ENZYME ACTIVITY; FEAR; GENOTYPE; HIPPOCAMPUS; LEARNING; LEARNING DISORDER; LONG TERM POTENTIATION; MEMORY CONSOLIDATION; MEMORY DISORDER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOCIAL ISOLATION;

ACETYLCYSTEINE; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANALYSIS OF VARIANCE; ANIMALS; ANTIOXIDANTS; BIOPHYSICS; BIOTINYLATION; CALPAIN; CELL LINE, TRANSFORMED; COGNITION DISORDERS; CONDITIONING (PSYCHOLOGY); CYCLIN-DEPENDENT KINASE 5; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEAR; HIPPOCAMPUS; HUMANS; LONG-TERM POTENTIATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PATCH-CLAMP TECHNIQUES; PEPTIDE FRAGMENTS; PRESENILIN-1; PROTEIN KINASE C-DELTA; RECEPTORS, METABOTROPIC GLUTAMATE; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SOCIAL ISOLATION; TIME FACTORS; TRANSFECTION;

EID: 84862813753     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2011.12.031     Document Type: Article

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