N 4-(3-bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d] pyrimidines as potent multiple receptor tyrosine kinase inhibitors: Design, synthesis, and in vivo evaluation

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 7, 2012, Pages 2444-2454

  Gangjee, Aleem ^a   Zaware, Nilesh ^a   Raghavan, Sudhir ^a   Yang, Jie ^a   Thorpe, Jessica E ^b   Ihnat, Michael A ^b  

^a DUQUESNE UNIVERSITY   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Antiangiogenic agents; Multiple receptor; Tyrosine kinase inhibitors

Indexed keywords

4 CHLORO 7 (2 CHLOROBENZYL) 7H PYRROLO[2,3 D]PYRIMIDINE 2,4 DIAMINE; 4 CHLORO 7H PYRROLO[2,3 D]PYRIMIDIN 2 AMINE; 7 BENZYL N4 (3 BROMOPHENYL) 7H PYRROLO[2,3 D]PYRIMIDINE 2,4 DIAMINE; 7 BIPHENYL 4 YLMETHYL N4 (3 BROMOPHENYL) 7H PYRROLO[2,3 D]PYRIMIDINE 2,4 DIAMINE; N4 (3 BROMOPHENYL) 7 (1 NAPHTHYLMETHYL) 7H PYRROLO[2,3 D]PYRIMIDINE 2,4 DIAMINE; N4 (3 BROMOPHENYL) 7 (2 CHLOROBENZYL) 7H PYRROLO[2,3 D]PYRIMIDINE 2,4 DIAMINE; N4 (3 BROMOPHENYL) 7 (2 METHYLBENZYL) 7H PYRROLO[2,3 D]PYRIMIDINE 2,4 DIAMINE; N4 (3 BROMOPHENYL) 7 (2 NAPHTHYLMETHYL) 7H PYRROLO[2,3 D]PYRIMIDINE 2,4 DIAMINE; N4 (3 BROMOPHENYL) 7 (2,5 DICHLOROBENZYL) 7H PYRROLO[2,3 D]PYRIMIDINE 2,4 DIAMINE; N4 (3 BROMOPHENYL) 7 (2,5 DIMETHOXYBENZYL) 7H PYRROLO[2,3 D]PYRIMIDINE 2,4 DIAMINE; N4 (3 BROMOPHENYL) 7 (3,4 DICHLOROBENZYL) 7H PYRROLO[2,3 D]PYRIMIDINE 2,4 DIAMINE; N4 (3 BROMOPHENYL) 7 (3,4,5 TRIMETHOXYBENZYL)7H PYRROLO[2,3 D]PYRIMIDINE 2,4 DIAMINE; N4 (3 BROMOPHENYL) 7 (4 CHLOROBENZYL) 7H PYRROLO[2,3 D]PYRIMIDINE 2,4 DIAMINE; N4 (3 BROMOPHENYL) 7 PYRROLO[2,3 D]PYRIMIDINE DERIVATIVE; N4 (3 BROMOPHENYL) 7H PYRROLO[2,3 D]PYRIMIDINE 2,4 DIAMINE; ORANTINIB; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CHLORINATION; COLON CANCER; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; NONHUMAN; NUCLEOPHILICITY;

ANIMALS; BINDING SITES; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DRUG DESIGN; HUMANS; INDOLES; MICE; MICE, NUDE; MOLECULAR DYNAMICS SIMULATION; NEOPLASMS; PROPIONIC ACIDS; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINES; PYRROLES; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; TRANSPLANTATION, HETEROLOGOUS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84862810926     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.01.029     Document Type: Article

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