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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 16, 2011, Pages 4742-4744

Discovery of novel fatty acid synthase (FAS) inhibitors based on the structure of ketoaceyl synthase (KS) domain

(10) Zeng, Xiao Fei a Li, Wei Wei a Fan, Hui Jin b Wang, Xiao Yan a Ji, Pan a Wang, Ze Rong a Ma, Shuang a Li, Lin Li a Ma, Xiao Feng b Yang, Sheng Yong a

a SICHUAN UNIVERSITY (China)

b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES (China)

Author keywords

Docking; Fatty acid synthase (FAS); Ketoaceyl synthase (KS) domain; Structure based pharmacophore modeling

Indexed keywords

FATTY ACID SYNTHASE; FATTY ACID SYNTHASE INHIBITOR;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CHEMICAL MODIFICATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME INHIBITION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MOLECULAR DOCKING; PHARMACOPHORE; THREE DIMENSIONAL IMAGING;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; FATTY ACID SYNTHETASE COMPLEX; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960922342 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.06.075 Document Type: Article

Times cited : (17)

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