-
1
-
-
17244375049
-
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
-
DOI 10.1038/nature03443
-
H.E. Bryant, N. Schultz, H.D. Thomas, K.M. Parker, D. Flower, and E. Lopez Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase Nature 434 2005 913 917 (Pubitemid 40559005)
-
(2005)
Nature
, vol.434
, Issue.7035
, pp. 913-917
-
-
Bryant, H.E.1
Schultz, N.2
Thomas, H.D.3
Parker, K.M.4
Flower, D.5
Lopez, E.6
Kyle, S.7
Meuth, M.8
Curtin, N.J.9
Helleday, T.10
-
2
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
DOI 10.1038/nature03445
-
H. Farmer, N. McCabe, C.J. Lord, A.N. Tutt, D.A. Johnson, and T.B. Richardson Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy Nature 434 2005 917 921 (Pubitemid 40559006)
-
(2005)
Nature
, vol.434
, Issue.7035
, pp. 917-921
-
-
Farmer, H.1
McCabe, H.2
Lord, C.J.3
Tutt, A.H.J.4
Johnson, D.A.5
Richardson, T.B.6
Santarosa, M.7
Dillon, K.J.8
Hickson, I.9
Knights, C.10
Martin, N.M.B.11
Jackson, S.P.12
Smith, G.C.M.13
Ashworth, A.14
-
3
-
-
0037986421
-
The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer
-
DOI 10.1002/ijc.11106
-
L.T. Hansen, C. Lundin, M. Spang-Thomsen, L.N. Petersen, and T. Helleday The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer Int J Cancer 105 2003 472 479 (Pubitemid 36578549)
-
(2003)
International Journal of Cancer
, vol.105
, Issue.4
, pp. 472-479
-
-
Hansen, L.T.1
Lundin, C.2
Spang-Thomsen, M.3
Petersen, L.N.4
Helleday, T.5
-
4
-
-
42249115685
-
The consequences of Rad51 overexpression for normal and tumor cells
-
H.L. Klein The consequences of Rad51 overexpression for normal and tumor cells DNA Repair (Amst) 7 2008 686 693
-
(2008)
DNA Repair (Amst)
, vol.7
, pp. 686-693
-
-
Klein, H.L.1
-
5
-
-
79955777649
-
Ku70 and Rad51 vary in their importance for the repair of doxorubicin- versus etoposide-induced DNA damage
-
I. Schonn, J. Hennesen, and D.C. Dartsch Ku70 and Rad51 vary in their importance for the repair of doxorubicin- versus etoposide-induced DNA damage Apoptosis 16 2011 359 369
-
(2011)
Apoptosis
, vol.16
, pp. 359-369
-
-
Schonn, I.1
Hennesen, J.2
Dartsch, D.C.3
-
6
-
-
0034760095
-
BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance
-
DOI 10.1016/S1097-2765(01)00357-4
-
A. Slupianek, C. Schmutte, G. Tombline, M. Nieborowska-Skorska, G. Hoser, and M.O. Nowicki BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance Mol Cell 8 2001 795 806 (Pubitemid 33030213)
-
(2001)
Molecular Cell
, vol.8
, Issue.4
, pp. 795-806
-
-
Slupianek, A.1
Schmutte, C.2
Tombline, G.3
Nieborowska-Skorska, M.4
Hoser, G.5
Nowicki, M.O.6
Pierce, A.J.7
Fishel, R.8
Skorski, T.9
-
7
-
-
50549086678
-
Uracil in DNA: Consequences for carcinogenesis and chemotherapy
-
S.H. Berger, D.L. Pittman, and M.D. Wyatt Uracil in DNA: consequences for carcinogenesis and chemotherapy Biochem Pharmacol 67 2008 697 706
-
(2008)
Biochem Pharmacol
, vol.67
, pp. 697-706
-
-
Berger, S.H.1
Pittman, D.L.2
Wyatt, M.D.3
-
8
-
-
52949117694
-
DNA damage and homologous recombination signaling induced by thymidylate deprivation
-
Z. Yang, A.S. Waldman, and M.D. Wyatt DNA damage and homologous recombination signaling induced by thymidylate deprivation Biochem Pharmacol 76 2008 987 996
-
(2008)
Biochem Pharmacol
, vol.76
, pp. 987-996
-
-
Yang, Z.1
Waldman, A.S.2
Wyatt, M.D.3
-
9
-
-
71349083599
-
Suppression of ERCC1 and Rad51 expression through ERK1/2 inactivation is essential in emodin-mediated cytotoxicity in human non-small cell lung cancer cells
-
J.C. Ko, Y.J. Su, S.T. Lin, J.Y. Jhan, S.C. Ciou, and C.M. Cheng Suppression of ERCC1 and Rad51 expression through ERK1/2 inactivation is essential in emodin-mediated cytotoxicity in human non-small cell lung cancer cells Biochem Pharmacol 79 2011 655 664
-
(2011)
Biochem Pharmacol
, vol.79
, pp. 655-664
-
-
Ko, J.C.1
Su, Y.J.2
Lin, S.T.3
Jhan, J.Y.4
Ciou, S.C.5
Cheng, C.M.6
-
10
-
-
79551495377
-
Modulation of Rad51, ERCC1, and thymidine phosphorylase by emodin result in synergistic cytotoxic effect in combination with capecitabine
-
J.C. Ko, M.S. Tsai, Y.H. Kuo, Y.F. Chiu, S.H. Weng, and Y.C. Su Modulation of Rad51, ERCC1, and thymidine phosphorylase by emodin result in synergistic cytotoxic effect in combination with capecitabine Biochem Pharmacol 81 2011 680 690
-
(2011)
Biochem Pharmacol
, vol.81
, pp. 680-690
-
-
Ko, J.C.1
Tsai, M.S.2
Kuo, Y.H.3
Chiu, Y.F.4
Weng, S.H.5
Su, Y.C.6
-
11
-
-
52049105168
-
Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase
-
B.C. Waldman, Y. Wang, K. Kilaru, Z. Yang, A. Bhasin, and M.D. Wyatt Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase DNA Repair 7 2008 1624 1635
-
(2008)
DNA Repair
, vol.7
, pp. 1624-1635
-
-
Waldman, B.C.1
Wang, Y.2
Kilaru, K.3
Yang, Z.4
Bhasin, A.5
Wyatt, M.D.6
-
12
-
-
4644318236
-
5-Fluoro-2′-deoxyuridine-induced cdc25A accumulation correlates with premature mitotic entry and clonogenic death in human colon cancer cells
-
DOI 10.1158/0008-5472.CAN-03-3040
-
L.A. Parsels, J.D. Parsels, D.C. Tai, D.J. Coughlin, and J. Maybaum 5-fluoro-2'-deoxyuridine-induced cdc25A accumulation correlates with premature mitotic entry and clonogenic death in human colon cancer cells Cancer Res 64 2004 6588 6594 (Pubitemid 39297918)
-
(2004)
Cancer Research
, vol.64
, Issue.18
, pp. 6588-6594
-
-
Parsels, L.A.1
Parsels, J.D.2
Tai, D.C.-H.3
Coughlin, D.J.4
Maybaum, J.5
-
13
-
-
33748292931
-
Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil
-
DOI 10.1038/sj.onc.1209532, PII 1209532
-
H.M. Robinson, R. Jones, M. Walker, G. Zachos, R. Brown, and J. Cassidy Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil Oncogene 25 2006 5359 5369 (Pubitemid 44330279)
-
(2006)
Oncogene
, vol.25
, Issue.39
, pp. 5359-5369
-
-
Robinson, H.M.R.1
Jones, R.2
Walker, M.3
Zachos, G.4
Brown, R.5
Cassidy, J.6
Gillespie, D.A.F.7
-
14
-
-
34248158210
-
Loss of ataxia telangiectasia mutated- and Rad3-related function potentiates the effects of chemotherapeutic drugs on cancer cell survival
-
DOI 10.1158/1535-7163.MCT-06-0679
-
D. Wilsker, and F. Bunz Loss of ataxia telangiectasia mutated- and Rad3-related function potentiates the effects of chemotherapeutic drugs on cancer cell survival Mol Cancer Ther 6 2007 1406 1413 (Pubitemid 46712004)
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, Issue.4
, pp. 1406-1413
-
-
Wilsker, D.1
Bunz, F.2
-
15
-
-
33748364583
-
Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase-activated protein kinase 2 in mediating DNA damage-induced cell cycle arrest: Implications for cancer therapy
-
DOI 10.1158/1535-7163.MCT-06-0077
-
Z. Xiao, J. Xue, T.J. Sowin, and H. Zhang Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase-activated protein kinase 2 in mediating DNA damage-induced cell cycle arrest: implications for cancer therapy Mol Cancer Ther 5 2006 1935 1943 (Pubitemid 44336564)
-
(2006)
Molecular Cancer Therapeutics
, vol.5
, Issue.8
, pp. 1935-1943
-
-
Xiao, Z.1
Xue, J.2
Sowin, T.J.3
Zhang, H.4
-
16
-
-
13944266820
-
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
-
DOI 10.1038/ncb1212
-
C.S. Sorensen, L.T. Hansen, J. Dziegielewski, R.G. Syljuasen, C. Lundin, and J. Bartek The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair Nat Cell Biol 7 2005 195 201 (Pubitemid 40268135)
-
(2005)
Nature Cell Biology
, vol.7
, Issue.2
, pp. 195-201
-
-
Sorensen, C.S.1
Hansen, L.T.2
Dziegielewski, J.3
Syljuasen, R.G.4
Lundin, C.5
Bartek, J.6
Helleday, T.7
-
17
-
-
3442896884
-
Replication Protein A phosphorylation and the cellular response to DNA damage
-
DOI 10.1016/j.dnarep.2004.03.028, PII S1568786404000874
-
S.K. Binz, A.M. Sheehan, and M.S. Wold Replication protein A phosphorylation and the cellular response to DNA damage DNA Repair (Amst) 3 2004 1015 1024 (Pubitemid 39004091)
-
(2004)
DNA Repair
, vol.3
, Issue.8-9
, pp. 1015-1024
-
-
Binz, S.K.1
Sheehan, A.M.2
Wold, M.S.3
-
18
-
-
32844461384
-
Phosphorylation of replication protein A by S-phase checkpoint kinases
-
DOI 10.1016/j.dnarep.2005.11.007, PII S1568786405003198
-
J.S. Liu, S.R. Kuo, and T. Melendy Phosphorylation of replication protein A by S-phase checkpoint kinases DNA Repair (Amst) 5 2006 369 380 (Pubitemid 43250664)
-
(2006)
DNA Repair
, vol.5
, Issue.3
, pp. 369-380
-
-
Liu, J.-S.1
Kuo, S.-R.2
Melendy, T.3
-
19
-
-
34548573123
-
RPA Mediates Recombination Repair During Replication Stress and Is Displaced from DNA by Checkpoint Signalling in Human Cells
-
DOI 10.1016/j.jmb.2007.07.068, PII S0022283607010467
-
K.M. Sleeth, C.S. Sorensen, N. Issaeva, J. Dziegielewski, J. Bartek, and T. Helleday RPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cells J Mol Biol 373 2007 38 47 (Pubitemid 47390721)
-
(2007)
Journal of Molecular Biology
, vol.373
, Issue.1
, pp. 38-47
-
-
Sleeth, K.M.1
Sorensen, C.S.2
Issaeva, N.3
Dziegielewski, J.4
Bartek, J.5
Helleday, T.6
-
20
-
-
0032993145
-
Mismatch repair proficiency and in vitro response to 5-fluorouracil
-
DOI 10.1016/S0016-5085(99)70558-5
-
J.M. Carethers, D.P. Chauhan, D. Fink, S. Nebel, R.S. Bresalier, and S.B. Howell Mismatch repair proficiency and in vitro response to 5-fluorouracil Gastroenterology 117 1999 123 131 (Pubitemid 29297628)
-
(1999)
Gastroenterology
, vol.117
, Issue.1
, pp. 123-131
-
-
Carethers, J.M.1
Chauhan, D.P.2
Fink, D.3
Nebel, S.4
Bresalier, R.S.5
Howell, S.B.6
Boland, C.R.7
-
21
-
-
14044264185
-
DNA mismatch repair-dependent response to fluoropyrimidine-generated damage
-
DOI 10.1074/jbc.M412105200
-
M. Meyers, M.W. Wagner, A. Mazurek, C. Schmutte, R. Fishel, and D.A. Boothman DNA mismatch repair-dependent response to fluoropyrimidine-generated damage J Biol Chem 280 2005 5516 5526 (Pubitemid 40280029)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.7
, pp. 5516-5526
-
-
Meyers, M.1
Wagner, M.W.2
Mazurek, A.3
Schmutte, C.4
Fishel, R.5
Boothman, D.A.6
-
22
-
-
77954748953
-
Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer
-
D.J. Sargent, S. Marsoni, G. Monges, S.N. Thibodeau, R. Labianca, and S.R. Hamilton Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer J Clin Oncol 28 2010 3219 3226
-
(2010)
J Clin Oncol
, vol.28
, pp. 3219-3226
-
-
Sargent, D.J.1
Marsoni, S.2
Monges, G.3
Thibodeau, S.N.4
Labianca, R.5
Hamilton, S.R.6
-
23
-
-
42349113807
-
Distinct RAD51 associations with RAD52 and BCCIP in response to DNA damage and replication stress
-
DOI 10.1158/0008-5472.CAN-07-6505
-
J. Wray, J. Liu, J.A. Nickoloff, and Z. Shen Distinct RAD51 associations with RAD52 and BCCIP in response to DNA damage and replication stress Cancer Res 68 2008 2699 2707 (Pubitemid 351556267)
-
(2008)
Cancer Research
, vol.68
, Issue.8
, pp. 2699-2707
-
-
Wray, J.1
Liu, J.2
Nickoloff, J.A.3
Shen, Z.4
-
24
-
-
4444318490
-
Involvement of base excision repair in response to therapy targeted at thymidylate synthase
-
L. Li, S.H. Berger, and M.D. Wyatt Involvement of base excision repair in response to therapy targeted at thymidylate synthase Mol Cancer Ther 3 2004 747 753 (Pubitemid 39193756)
-
(2004)
Molecular Cancer Therapeutics
, vol.3
, Issue.6
, pp. 747-753
-
-
Li, L.1
Berger, S.H.2
Wyatt, M.D.3
-
25
-
-
26944498660
-
Determination of apoptosis, uracil incorporation, DNA strand breaks, and sister chromatid exchanges under conditions of thymidylate deprivation in a model of BER deficiency
-
DOI 10.1016/j.bcp.2005.08.016, PII S0006295205005630
-
L. Li, E.E. Connor, S.H. Berger, and M.D. Wyatt Determination of apoptosis, uracil incorporation, DNA strand breaks, and sister chromatid exchanges under conditions of thymidylate deprivation in a model of BER deficiency Biochem Pharmacol 70 2005 1458 1468 (Pubitemid 41483456)
-
(2005)
Biochemical Pharmacology
, vol.70
, Issue.10
, pp. 1458-1468
-
-
Li, L.1
Connor, E.E.2
Berger, S.H.3
Wyatt, M.D.4
-
26
-
-
37549072672
-
Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase
-
Y. Luo, M. Walla, and M.D. Wyatt Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase DNA Repair (Amst) 7 2008 162 169
-
(2008)
DNA Repair (Amst)
, vol.7
, pp. 162-169
-
-
Luo, Y.1
Walla, M.2
Wyatt, M.D.3
-
27
-
-
0033569684
-
XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
-
DOI 10.1101/gad.13.20.2633
-
A.J. Pierce, R.D. Johnson, L.H. Thompson, and M. Jasin XRCC3 promotes homology-directed repair of DNA damage in mammalian cells Genes Dev 13 1999 2633 2638 (Pubitemid 29508550)
-
(1999)
Genes and Development
, vol.13
, Issue.20
, pp. 2633-2638
-
-
Pierce, A.J.1
Johnson, R.D.2
Thompson, L.H.3
Jasin, M.4
-
28
-
-
0032568321
-
Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells
-
T. Kanda, K.F. Sullivan, and G.M. Wahl Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells Curr Biol 8 1998 377 385 (Pubitemid 28173996)
-
(1998)
Current Biology
, vol.8
, Issue.7
, pp. 377-385
-
-
Kanda, T.1
Sullivan, K.F.2
Wahl, G.M.3
-
29
-
-
0141621266
-
Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases
-
DOI 10.1074/jbc.M307088200
-
D. Cortez Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases J Biol Chem 278 2003 37139 37145 (Pubitemid 37175228)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.39
, pp. 37139-37145
-
-
Cortez, D.1
-
30
-
-
20244388673
-
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
-
DOI 10.1128/MCB.25.9.3553-3562.2005
-
R.G. Syljuasen, C.S. Sorensen, L.T. Hansen, K. Fugger, C. Lundin, and F. Johansson Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage Mol Cell Biol 25 2005 3553 3562 (Pubitemid 40559562)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.9
, pp. 3553-3562
-
-
Syljuasen, R.G.1
Sorensen, C.S.2
Hansen, L.T.3
Fugger, K.4
Lundin, C.5
Johansson, F.6
Helleday, T.7
Sehested, M.8
Lukas, J.9
Bartek, J.10
-
31
-
-
0036245507
-
Biochemical and molecular effects of UCN-01 in combination with 5-fluorodeoxyuridine in A431 human epidermoid cancer cells
-
DOI 10.1097/00001813-200203000-00008
-
J.L. Grem, K.D. Danenberg, V. Kao, P.V. Danenberg, and D. Nguyen Biochemical and molecular effects of UCN-01 in combination with 5-fluorodeoxyuridine in A431 human epidermoid cancer cells Anticancer Drugs 13 2002 259 270 (Pubitemid 34492708)
-
(2002)
Anti-Cancer Drugs
, vol.13
, Issue.3
, pp. 259-270
-
-
Grem, J.L.1
Danenberg, K.D.2
Kao, V.3
Danenberg, P.V.4
Nguyen, D.5
-
32
-
-
0031670310
-
UCN-01 suppresses thymidylate synthase gene expression and enhances 5- fluorouracil-induced apoptosis in a sequence-dependent manner
-
C.T. Hsueh, D. Kelsen, and G.K. Schwartz UCN-01 suppresses thymidylate synthase gene expression and enhances 5-fluorouracil-induced apoptosis in a sequence-dependent manner Clin Cancer Res 4 1998 2201 2206 (Pubitemid 28415668)
-
(1998)
Clinical Cancer Research
, vol.4
, Issue.9
, pp. 2201-2206
-
-
Hsueh, C.-T.1
Kelsen, D.2
Schwartz, G.K.3
-
33
-
-
77954032829
-
Poly(ADP)-ribose polymerase inhibition: Frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval
-
P.C. Fong, T.A. Yap, D.S. Boss, C.P. Carden, M. Mergui-Roelvink, and C. Gourley Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval J Clin Oncol 28 2010 2512 2519
-
(2010)
J Clin Oncol
, vol.28
, pp. 2512-2519
-
-
Fong, P.C.1
Yap, T.A.2
Boss, D.S.3
Carden, C.P.4
Mergui-Roelvink, M.5
Gourley, C.6
-
34
-
-
51449113045
-
Targeted therapy for cancer using PARP inhibitors
-
C.J. Lord, and A. Ashworth Targeted therapy for cancer using PARP inhibitors Curr Opin Pharmacol 8 2008 363 369
-
(2008)
Curr Opin Pharmacol
, vol.8
, pp. 363-369
-
-
Lord, C.J.1
Ashworth, A.2
-
35
-
-
78751610848
-
Iniparib plus chemotherapy in metastatic triple-negative breast cancer
-
J. O'Shaughnessy, C. Osborne, J.E. Pippen, M. Yoffe, D. Patt, and C. Rocha Iniparib plus chemotherapy in metastatic triple-negative breast cancer N Engl J Med 364 2011 205 214
-
(2011)
N Engl J Med
, vol.364
, pp. 205-214
-
-
O'Shaughnessy, J.1
Osborne, C.2
Pippen, J.E.3
Yoffe, M.4
Patt, D.5
Rocha, C.6
-
36
-
-
79961077772
-
Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening
-
F. Huang, N.A. Motlekar, C.M. Burgwin, A.D. Napper, S.L. Diamond, and A.V. Mazin Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening ACS Chem Biol 6 2011 628 635
-
(2011)
ACS Chem Biol
, vol.6
, pp. 628-635
-
-
Huang, F.1
Motlekar, N.A.2
Burgwin, C.M.3
Napper, A.D.4
Diamond, S.L.5
Mazin, A.V.6
-
37
-
-
39849097680
-
Resistance to therapy caused by intragenic deletion in BRCA2
-
DOI 10.1038/nature06548, PII NATURE06548
-
S.L. Edwards, R. Brough, C.J. Lord, R. Natrajan, R. Vatcheva, and D.A. Levine Resistance to therapy caused by intragenic deletion in BRCA2 Nature 451 2008 1111 1115 (Pubitemid 351317441)
-
(2008)
Nature
, vol.451
, Issue.7182
, pp. 1111-1115
-
-
Edwards, S.L.1
Brough, R.2
Lord, C.J.3
Natrajan, R.4
Vatcheva, R.5
Levine, D.A.6
Boyd, J.7
Reis-Filho, J.S.8
Ashworth, A.9
|