Molecular imaging of tumor metabolism and apoptosis

Oncogene

Volumn 30, Issue 40, 2011, Pages 4141-4151

  Haberkorn, U ^a,b   Markert, A ^a   Mier, W ^a   Askoxylakis, V ^a   Altmann, A ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

amino acid transport; apoptosis; glucose metabolism; imaging; PET; tumor

Indexed keywords

BIOLOGICAL MARKER; CYCLOPHOSPHAMIDE; DOPA; FLUORODEOXYGLUCOSE F 18; GLUCOSE; METHOTREXATE; ONCOPROTEIN; PHOSPHORYLCHOLINE;

ADENOCARCINOMA; AMINO ACID TRANSPORT; APOPTOSIS; B CELL LYMPHOMA; BREAST CANCER; CANCER DIAGNOSIS; CANCER STAGING; CELL DEATH; CONTRAST ENHANCEMENT; DOWN REGULATION; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG UPTAKE; ENZYME ACTIVITY; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; HEAD AND NECK CANCER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LUNG CANCER; LYMPHOMA; MALIGNANT TRANSFORMATION; MELANOMA; METABOLISM; MITOCHONDRIAL MEMBRANE; MOLECULAR IMAGING; NONHUMAN; PATIENT MONITORING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; RADIOACTIVITY; REVIEW; SARCOMA; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA;

AMINO ACIDS; ANIMALS; APOPTOSIS; BIOLOGICAL TRANSPORT; HUMANS; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY;

EID: 80053609996     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.169     Document Type: Review

References (99)

1. Aboagye EO, Bhujwalla ZM. (1999). Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells. Cancer Res 59: 80-84. (Pubitemid 29062961)
2. Ackerstaff E, Glunde K, Bhujwalla ZM. (2003). Choline phospholipid metabolism: a target in cancer cells? J Cell Biochem 90: 525-533. (Pubitemid 37243700)
3. Bassa P, Kim EE, Inoue T, Wong FC, Korkmaz M, Yang DJ et al. (1996). Evaluation of preoperative chemotherapy using PET with fluorine-18- fluorodeoxyglucose in breast cancer. J Nucl Med 37: 931-938. (Pubitemid 126447124)
4. Bauer C, Bauder-Wuest U, Mier W, Haberkorn U, Eisenhut M. (2005). 131I-labeled peptides as caspase substrates for apoptosis imaging. J Nucl Med 46: 1066-1074. (Pubitemid 43733525)
5. Bergstrom M, Muhr C, Lundberg PO, Bergstrom K, Gee AD, Fasth KJ et al. (1987). Rapid decrease in amino acid metabolism in prolactin-secreting pituitary adenomas after bromocriptine treatment: a PET study. J Comput Assist Tomogr 11: 815-819. (Pubitemid 17138491)
6. Blankenberg FG, Katsikis PD, Tait JF, Davis RE, Naumovski L, Ohtsuki K et al. (1998). In vivo detection and imaging of phosphatidylserine expression during programmed cell death. Proc Natl Acad Sci USA 95: 6349-6354. (Pubitemid 28249015)
7. Blankenberg FG, Katsikis PD, Tait JF, Davis RE, Naumovski L, Ohtsuki K et al. (1999). Imaging of apoptosis (programmed cell death) with 99mTc annexin V. J Nucl Med 40: 184-191. (Pubitemid 29044190)
8. Bogin L, Papa MZ, Polak-Charcon S, Degani H. (1998). TNF-induced modulations of phospholipid metabolism in human breast cancer cells. Biochim Biophys Acta 1392: 217-232. (Pubitemid 28287326)
9. Brown RS, Leung JY, Kison PV, Zasadny KR, Flint A, Wahl RL. (1999). Glucose transporters and FDG uptake in untreated primary human non-small cell lung cancer. J Nucl Med 40: 556-565. (Pubitemid 29171796)
10. Busch H, Davis JR, Honig GR, Anderson DC, Nair PV, Nyhan WL et al. (1959). The uptake of a variety of amino acids into nuclear proteins of tumors and other tissues. Cancer Res 19: 1030-1039.
11. Cai H, Erhardt P, Troppmair J, Diaz-Meco MT, Sithanandam G, Rapp UR et al. (1993). Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction. Mol Cell Biol 13: 7645-7651. (Pubitemid 23354289)
12. Christensen HN. (1990). Role of amino acid transport and counter-transport in nutrition and metabolism. Physiol Rev 70: 43-76.
13. Cuadrado A, Carnero A, Dolfi F, Jimenez B, Lacal JC. (1993). Phosphorylcholine: a novel second messenger essential for mito-genic activity of growth factors. Oncogene 8: 2959-2968. (Pubitemid 23312899)
14. Cuadrado A, Issing W, Fleming TP, Molloy CJ. (1994). Uneven distribution of protein kinase C-a and-b isozymes in human sarcomas and carcinomas. J Cell Physiol 159: 434-440. (Pubitemid 24188983)
15. Daemen BJ, Elsinga PH, Mooibroek J, Paans AM, Wieringa AR, Konings AW et al. (1991). PET measurements of hyperthermia-induced suppression of protein synthesis in tumors in relation to effects on tumor growth. J Nucl Med 32: 1587-1592.
16. de Certaines JD, Larsen VA, Podo F, Carpinelli G, Briot O, Henriksen O. (1993). In vivo 31P MRS of experimental tumours. NMR Biomed 6: 345-365. (Pubitemid 2031145)
17. DeGrado TL, Coleman RE, Wang S, Baldwin SW, Orr MD, Robertson CN et al. (2000). Price synthesis and evaluation of 18F-labeled choline as an oncologic tracer for positron emission tomography: initial findings in prostate cancer. Cancer Res 61: 110-117. (Pubitemid 32095708)
18. DeGrado TR, Coleman RE, Wang S, Baldwin SW, Orr MD, Robertson CN et al. (2001). Synthesis and evaluation of (18)F-labeled choline analogs as oncologic PET tracers. J Nucl Med 42: 1805-1814. (Pubitemid 34016349)
19. Dunzendorfer U, Schmall B, Bigler RE, Zanzonico PB, Conti PS, Dahl JR et al. (1981). Synthesis and body distribution of alpha-aminoisobutyric acid-L-11C in normal and prostate cancer bearing rat after chemotherapy. Eur J Nucl Med 6: 535-538. (Pubitemid 12238115)
20. Flier JS, Mueckler MM, Usher P, Lodish HF. (1987). Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Science 235: 1492-1495. (Pubitemid 17038084)
21. Galetic I, Andjelkovic M, Meier R, Brodbeck D, Park J, Hemmings BA. (1999). Mechanism of protein kinase B activation by insulin/insulin-like growth factor-1 revealed by specific inhibitors of phosphoinositide 3-kinase-significance for diabetes and cancer. Pharmacol Ther 82: 409-425. (Pubitemid 29255934)
22. Galons JP, Job C, Gillies RJ. (1995). Increase of GPC levels in cultured mammalian cells during acidosis. A 31P MR spectroscopy study using a continuous bioreactor system. Magn Reson Med 33: 422-426.
23. Gallagher BM, Ansari A, Atkins H, Casella V, Christman DR et al. (1977). 18F-labeled 2-deoxy-2-fluoro-D-glucose as a radiopharma-ceutical for measuring regional myocardial glucose metabolism in vivo: tissue distribution and imaging studies in animals. J Nucl Med 18: 990-996.
24. Ganapathy V, Thangaraju M, Prasad PD. (2009). Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond. Pharmacol Ther 121: 29-40.
25. Gribbestad IS, Sitter B, Lundgren S, Krane J, Axelson D. (1999). Metabolite composition in breast tumors examined by proton nuclear magnetic resonance spectroscopy. Anticancer Res 19: 1737-1746. (Pubitemid 29392730)
26. Guthridge CJ, Stampfer MR, Clark MA, Steiner MR. (1994). Phospholipases A2 in ras-transformed and immortalized human mammary epithelial cells. Cancer Lett 86: 11-21.
27. Haberkorn U, Altmann A, Kamencic H, Morr I, Traut U, Henze M et al. (2001a). Glucose transport and apoptosis after gene therapy with HSV thymidine kinase. Eur J Nucl Med 28: 1690-1696. (Pubitemid 33036113)
28. Haberkorn U, Altmann A, Morr I, Germann C, Oberdorfer F, van Kaick G. (1997a). Multi tracer studies during gene therapy of hepatoma cells with HSV thymidine kinase and ganciclovir. J Nucl Med 38: 1048-1054. (Pubitemid 27339609)
29. Haberkorn U, Bellemann ME, Altmann A, Gerlach L, Morr I, Oberdorfer F et al. (1997b). PET 2-fluoro-2-deoxyglucose uptake in rat prostate adenocarcinoma during chemotherapy with gemcita-bine. J Nucl Med 38: 1215-1221. (Pubitemid 27332617)
30. Haberkorn U, Bellemann ME, Brix G, Kamencic H, Morr I, Traut U et al. (2001b). Apoptosis and changes in glucose transport early after treatment of Morris hepatoma with gemcitabine. Eur J Nucl Med 28: 418-425. (Pubitemid 32260907)
31. Haberkorn U, Bellemann ME, Gerlach L, Morr I, Trojan H, Brix G et al. (1998). Uncoupling of 2-fluoro-2-deoxyglucose transport and phosphorylation in rat hepatoma during gene therapy with HSV thymidine kinase. Gene Ther 5: 880-887. (Pubitemid 28371904)
32. Haberkorn U, Kinscherf R, Krammer PH, Mier W, Eisenhut M. (2001c). Investigation of a potential scintigraphic marker of apoptosis: radioiodinated Z-Val-Ala-DL-Asp(O-methyl)-fluoro-methyl ketone. Nucl Med Biol 28: 793-798. (Pubitemid 32900637)
33. Haberkorn U, Mier W, Eisenhut M. (2005). Scintigraphic imaging of gene expression and gene transfer. Curr Med Chem 12: 779-794. (Pubitemid 40394330)
34. Haberkorn U, Reinhardt M, Strauss LG, Oberdorfer F, Berger MR, Altmann A et al. (1992). Metabolic design of combination therapy: use of enhanced fluorodeoxyglucose uptake caused by chemotherapy. J Nucl Med 33: 1981-1987.
35. Haberkorn U, Strauss LG, Dimitrakopoulou A, Engenhart R, Oberdorfer F, Ostertag H et al. (1991). PET studies of fluorodeoxy-glucose metabolism in patients with recurrent colorectal tumors receiving radiotherapy. J Nucl Med 32: 1485-1490.
36. Haberkorn U, Strauss LG, Dimitrakopoulou A, Seiffert E, Oberdorfer F, Ziegler S et al. (1993). Fluorodeoxyglucose imaging of advanced head and neck cancer after chemotherapy. J Nucl Med 34: 12-17. (Pubitemid 23014214)
37. Haberkorn U, Ziegler SI, Oberdorfer F, Trojan H, Haag D, Peschke P et al. (1994). FDG uptake, tumor proliferation and expression of glycolysis associated genes in animal tumor models. Nucl Med Biol 21: 827-834. (Pubitemid 24263576)
38. Haeffner EW. (1975). Studies on choline permeation through the plasma membrane and its incorporation into phosphatidyl choline of Ehrlich-Lettre- ascites tumor cells in vitro. Eur J Biochem 51: 219-228.
39. Hara T, Kosaka N, Kishi H. (1998). PET imaging of prostate cancer using carbon-11-choline. J Nucl Med 39: 990-995. (Pubitemid 28270113)
40. Hara T, Kosaka N, Kishi H. (2002). Development of (18)F- fluoroethylcholine for cancer imaging with PET: synthesis, biochemistry, and prostate cancer imaging. J Nucl Med 43: 187-199. (Pubitemid 34151041)
41. Hayes N, Biswas C, Strout HV, Berger J. (1993). Activation by protein synthesis inhibitors of glucose transport into L6 muscle cells. Biochem Biophys Res Commun 190: 881-887. (Pubitemid 23207847)
42. Heiss P, Mayer S, Herz M, Wester HJ, Schwaiger M, Senekowitsch-Schmidtke R. (1999). Investigation of transport mechanism and uptake kinetics of O-(2-[18F]fluoroethyl)-L-tyrosine in vitro and in vivo. J Nucl Med 40: 1367-1373. (Pubitemid 29385647)
43. Hernandez-Alcoceba R, Fernandez F, Lacal JC. (1999). In vivo antitumor activity of choline kinase inhibitors: a novel target for anticancer drug discovery. Cancer Res 59: 3112-3118. (Pubitemid 29316010)
44. Higashi K, Clavo AC, Wahl RL. (1993). In vitro assessment of 2-fluoro-2-deoxy-D-glucose, L-methionine and thymidine as agents to monitor the early response of a human adenocarcinoma cell line to radiotherapy. J Nucl Med 34: 773-779. (Pubitemid 23141556)
45. Hughes CS, Shen JW, Subjeck JR. (1989). Resistance to etoposide induced by three glucose-regulated stresses in Chinese hamster ovary cells. Cancer Res 49: 4452-4454. (Pubitemid 19208343)
46. Ishiwata K, Enomoto K, Sasaki T, Elsinga PH, Senda M, Okazumi S et al. (1996). A feasibility study on L-[1-carbon11]tyrosine and L-[methyl-carbon-11] methionine to assess liver protein synthesis. J Nucl Med 37: 279-285.
47. Isselbacher KJ. (1972). Sugar and amino acid transport by cells in culture: differences between normal and malignant cells. N Engl J Med 286: 929-933.
48. Jager PL, Vaalburg W, Pruim J, de Vries EG, Langen KJ, Piers DA. (2001). Radiolabeled amino acids: basic aspects and clinical applications in oncology. J Nucl Med 42: 432-445. (Pubitemid 32207394)
49. Jansson T, Westlin JE, Ahlstrom H, Lilja A, Langstrom B, Bergh J et al. (1995). Positron emission tomography studies in patients with locally advanced and/or metastatic breast cancer: a method for early therapy evaluation. J Clin Oncol 13: 1470-1477.
50. Katz-Brull R, Degani H. (1996). Kinetics of choline transport and phosphorylation in human breast cancer cells; NMR application of the zero trans method. Anticancer Res 16: 1375-1380.
51. Kiss Z, Crilly KS, Anderson WH. (1993). Carcinogens stimulate phosphorylation of ethanolamine derived from increased hydrolysis of phosphatidylethanolamine in C3H/101/2 fibroblasts. FEBS Lett 336: 115-118. (Pubitemid 23362016)
52. Kobori O, Kirihara Y, Kosaka N, Hara T. (1999). Positron emission tomography of esophageal carcinoma using 11C-choline and 18F-fluorodeoxyglucose. Cancer 86: 1638-1648.
53. Kurhanewicz J, Vigneron DB, Nelson SJ. (2000). Threedimensional magnetic resonance spectroscopic imaging of brain and prostate cancer. Neoplasia 2: 166-189. (Pubitemid 30123187)
54. Kuwert T, Probst-Cousin S, Woesler B, Morgenroth C, Lerch H, Matheja P et al. (1997). Iodine-123-alpha-methyl tyrosine in glioma: correlation with cellular density and proliferative activity. J Nucl Med 38: 1551-1555. (Pubitemid 27443954)
55. Kwee SA, Coel MN, Lim J, Ko JP. (2004). Combined use of F-18 fluorocholine positron emission tomography and magnetic resonance spectroscopy for brain tumor evaluation. J Neuroimaging 14: 285-289. (Pubitemid 38781403)
56. Kwee SA, Wei H, Sesterhenn I, Yun D, Coel MN. (2006). Localization of primary prostate cancer with dual-phase 18F-fluorocholine PET. J Nucl Med 47: 262-269. (Pubitemid 46780891)
57. Kypta RM, Goldberg Y, Ulug ET, Courtneidge SA. (1990). Association between the PDGF receptor and members of the src family of tyrosine kinases. Cell 62: 481-492.
58. Langen KJ, Ziemons K, Kiwit JC, Herzog H, Kuwert T, Bock WJ et al. (1997). 3-[123I]iodo-alpha-methyltyrosine and [methyl-11C]-L-methionine uptake in cerebral gliomas: a comparative study using SPECT and PET. J Nucl Med 38: 517-522.
59. Leach MO, Verrill M, Glaholm J, Smith TA, Collins DJ, Payne GS et al. (1998). Measurements of human breast cancer using magnetic resonance spectroscopy: a review of clinical measurements and a report of localized 31P measurements of response to treatment. NMR Biomed 11: 314-340. (Pubitemid 28547368)
60. Li X, Lu Y, Pirzkall A, McKnight T, Nelson SJ. (2002). Analysis of the spatial characteristics of metabolic abnormalities in newly diagnosed glioma patients. J Magn Reson Imaging 16: 229-237. (Pubitemid 34920420)
61. Lindholm P, Leskinen S, Lapela M. (1998). Carbon-11-methionine uptake in squamous cell head and neck cancer. J Nucl Med 39: 1393-1397. (Pubitemid 28373564)
62. Machado de Domenech EE, Sols A. (1980). Specificity of hexokinases towards some uncommon substrates and inhibitors. FEBS Lett 119: 174-176.
63. Martin SJ, Reutelingsperger CPM, McGahon AJ. (1995). Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med 182: 1545-1556.
64. McConathy J, Martarello L, Malveaux EJ, Camp VM, Simpson NE, Simpson CP et al. (2002). Radiolabeled amino acids for tumor imaging with PET: radiosynthesis and biological evaluation of 2-amino-3-[18F]fluoro-2- methylpropanoic acid and 3-[18F]fluoro-2-methyl-2-(methylamino)propanoic acid. J Med Chem 45: 2240-2249. (Pubitemid 34525804)
65. Molloy CJ, Bottaro DP, Fleming TP, Marshall MS, Gibbs JB, Aaronson SA. (1989). PDGF induction of tyrosine phosphorylation of GTPase activating protein. Nature (Lond) 342: 711-714. (Pubitemid 20001593)
66. Negendank W. (1992). Studies of human tumors by MRS: a review. NMR Biomed 5: 303-324.
67. Noh DY, Ahn SJ, Lee RA, Park IA, Kim JH, Suh PG et al. (2000). Overexpression of phospholipase D1 in human breast cancer tissues. Cancer Lett 161: 207-214.
68. Ogawa T, Kanno I, Shishido F, Inugami A, Higano S, Fujita H et al. (1991). Clinical value of PET with 18F-fluorodeoxyglucose and L-methyl-11C-methionine for diagnosis of recurrent brain tumor and radiation injury. Acta Radiol 32: 197-202.
69. Pauleit D, Floeth F, Hamacher K, Riemenschneider MJ, Reifenberger G, Muller HW et al. (2005). O-(2-[18F]fluoroethyl)-L-tyrosine PET combined with MRI improves the diagnostic assessment of cerebral gliomas. Brain 128: 678-687. (Pubitemid 40380202)
70. Popperl G, Gotz C, Rachinger W, Gildehaus FJ, Tonn JC, Tatsch K. (2004). Value of O-(2-[18F]fluoroethyl)-L-tyrosine PET for the diagnosis of recurrent glioma. Eur J Nucl Med Mol Imaging 31: 1464-1470. (Pubitemid 39592765)
71. Ramirez de Molina A, Gutierrez R, Ramos MA, Silva JM, Silva J, Bonilla F et al. (2002a). Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy. Oncogene 21: 4317-4322. (Pubitemid 34753838)
72. Ramirez de Molina A, Rodriguez-Gonzalez A, Gutierrez R, Martinez-Pineiro L, Sanchez J, Bonilla F et al. (2002b). Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers. Biochem Biophys Res Commun 296: 580-583.
73. Rau FC, Weber WA, Wester HJ, Herz M, Becker I, Kruger A et al. (2002). O-(2-[18F]fluoroethyl)-L-tyrosine (FET): a tracer for differentiation of tumor from inflammation in murine lymph nodes. Eur J Nucl Med 29: 1039-1046.
74. Ronen SM, Jackson LE, Beloueche M, Leach MO. (2001). Magnetic resonance detects changes in phosphocholine associated with Ras activation and inhibition in NIH 3T3 cells. Br J Cancer 84: 691-696. (Pubitemid 32239005)
75. Rozental JM, Levine RL, Nickles RJ, Dobkin JA. (1989). Glucose uptake by gliomas after treatment. A positron emission tomo-graphic study. Arch Neurol 46: 1302-1307. (Pubitemid 20013362)
76. Saier MH, Daniels JR, Boerner P, Lin J. (1988). Animal amino acid transport systems in animal cells: potential targets of oncogene action and regulators of cellular growth. J Membr Biol 104: 1-20.
77. Salber D, Stoffels G, Pauleit D, Oros-Peusquens AM, Shah NJ, Klauth P et al. (2007). Differential uptake of O-(2-18F-fluoroethyl)-L-tyrosine, L-3H-methionine, and 3H-deoxyglucose in brain abscesses. J Nucl Med 48: 2056-2062. (Pubitemid 350232317)
78. Scanlon K, Cashmore AR, Kashani-Sabet M, Pallai M, Dreyer RN, Moroson BA et al. (1987). Inhibition of methionine uptake by methotrexate in mouse leukemia L1210. Cancer Chemother Pharmacol 19: 21-24. (Pubitemid 17017033)
79. Scanlon K, Safirstein RL, Thies H, Gross RB, Waxman S, Guttenplan JB. (1983). Inhibition of amino acid transport by cis-diaminedi-chloroplatinum (II) derivatives L1210 murine leukemia cells. Cancer Res 43: 4211-4215. (Pubitemid 13044040)
80. Schaider H, Haberkorn U, Berger MR, Oberdorfer F, Morr I, van Kaick G. (1996). Application of alpha-aminoisobutyric acid, L-methionine, thymidine and 2-fluoro-2-deoxy-D-glucose to monitor effects of chemotherapy in a human colon carcinoma cell line. Eur J Nucl Med 23: 55-60. (Pubitemid 26013616)
81. Shawver LK, Olson SA, White MK, Weber MJ. (1987). Degradation and biosynthesis of the glucose transporter protein in chicken embryo fibroblasts transformed by the src oncogene. Mol Cell Biol 7: 2112-2118.
82. Shoup TM, Olson J, Hoffman JM, Votaw J, Eshima D, Eshima L et al. (1999). Synthesis and evaluation of [18F]1-amino-3-fluorocyclobu-tane-1-carboxylic acid to image brain tumors. J Nucl Med 40: 331-338. (Pubitemid 29077098)
83. Sieger S, Jiang S, Kleinschmidt J, Eskerski H, Schonsiegel F, Altmann A et al. (2004). Tumor-specific gene expression using regulatory elements of the glucose transporter isoform 1 gene. Cancer Gene Ther 11: 41-51. (Pubitemid 38057814)
84. Sieger S, Jiang S, Schonsiegel F, Eskerski H, Kubler W, Altmann A et al. (2003). Tumor-specific activation of the sodium/iodide symporter gene under control of the glucose transporter gene 1 promoter (GTI-1.3). Eur J Nucl Med Mol Imaging 30: 748-756. (Pubitemid 36612959)
85. Singh D, Banerji AK, Dwarakanath BS, Tripathi RP, Gupta JP, Mathew TL et al. (2005). Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblas-toma multiforme. Strahlenther Onkol 181: 507-514. (Pubitemid 41059520)
86. Sols A, Crane RK. (1954). Substrate specificity of brain hexokinase. J Biol Chem 210: 581-595.
87. Uehara H, Miyagawa T, Tjuvajev J, Joshi R, Beattie B, Oku T et al. (1997). Imaging experimental brain tumors with 1-aminocyclo-pentane carboxylic acid and alpha-aminoisobutyric acid: comparison to fluorodeoxyglucose and diethylenetriaminepentaacetic acid in morphologically defined tumor regions. J Cereb Blood Flow Metab 17: 1239-1253. (Pubitemid 27514749)
88. Vaalburg W, Coenen HH, Crouzel C, Elsinga PH, Langstrom B, Lemaire C et al (1992). Amino acids for the measurement of protein synthesis in vivo by PET. Int J Rad Appl Instrum B 19: 227-237.
89. Vansteenkiste JF, Stroobants SG, Dupont PJ, De Leyn PR, Verbeken EK, Deneffe GJ et al. (1999). Prognostic importance of the standardized uptake value on (18)F-fluoro-2-deoxy-glucose-posi-tron emission tomography scan in non-small-cell lung cancer: an analysis of 125 cases. Leuven Lung Cancer Group. J Clin Oncol 17: 3201-3206. (Pubitemid 29470652)
90. Vees H, Senthamizhchelvan S, Miralbell R, Weber DC, Ratib O, Zaidi H. (2009). Assessment of various strategies for 18F-FET PET-guided delineation of target volumes in high-grade glioma patients. Eur J Nucl Med Mol Imaging 36: 182-193.
91. Villa P, Kaufmann SH, Earnshwa WC. (1997). Caspases and caspase inhibitors. TIBS 22: 388-393. (Pubitemid 27438202)
92. Wertheimer E, Sasson S, Cerasi E, Ben-Neriah Y. (1991). The ubiquitous glucose transporter GLUT-1 belongs to the glucose-regulated protein family of stress-inducible proteins. Proc Natl Acad Sci USA 88: 2525-2529. (Pubitemid 21916450)
93. Wester HJ, Herz M, Weber W, Heiss P, Senekowitsch-Schmidtke R, Schwaiger M et al. (1999). Synthesis and radiopharmacology of O-(2-[18F]fluoroethyl)-L- tyrosine for tumor imaging. J Nucl Med 40: 205-212. (Pubitemid 29044193)
94. Widnell CC, Baldwin SA, Davies A, Martin S, Pasternak CA. (1990). Cellular stress induces a redistribution of the glucose transporter. FASEB J 4: 1634-1637.
95. Wienhard K, Herholz K, Coenen HH, Rudolf J, Kling P, Stocklin G et al. (1991). Increased amino acid transport into brain tumors measured by PET of L-(2-18F)fluorotyrosine. J Nucl Med 32: 1338-1346.
96. Willemsen AT, vanWaarde A, Paans AM, Pruim J, Luurtsema G, Go KG et al. (1995). In vivo protein synthesis rate determination in primary or recurrent brain tumors using L-[1-11C]-tyrosine and PET. J Nucl Med 36: 411-419.
97. Wurker M, Herholz K, Voges J, Pietrzyk U, Treuer H, Bauer B et al. (1996). Glucose consumption and methionine uptake in low-grade gliomas after iodine-125 brachytherapy. Eur J Nucl Med 23: 583-586. (Pubitemid 26140591)
98. Zhou D, Chu W, Chen DL, Wang Q, Reichert DE, Rothfuss J et al. (2009). 18F and 11C-labeled N-benzyl-isatin sulfonamide analogues as PET tracers for apoptosis: synthesis, radiolabelling mechanism, and in vivo imaging study of apoptosis in Fas-treated mice using 11C-WC-98. Org BiomolChem 7: 1337-1348.
99. Zwaal RFA, Schroit AJ. (1997). Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood 89: 1121-1132. (Pubitemid 27079974)