P53-Independent expression of wild-type p53-induced phosphatase 1 (Wip1) in methylmethane sulfonate-treated cancer cell lines and human tumors

International Journal of Biochemistry and Cell Biology

Volumn 44, Issue 6, 2012, Pages 896-904

  Park, Ji Young ^a   Song, Ji Young ^a   Kim, Hyun Mi ^a   Han, Hye Sook ^a   Seol, Hyang Sook ^a   Jang, Se Jin ^a   Choi, Jene ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

MMS; p38 MAPK; p53; Protein phosphatase; Wip1

Indexed keywords

DNA; FLUOROURACIL; IRINOTECAN; METHYLMETHANE SULFONATE; OXALIPLATIN; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN P53; SULFONATED IMMUNOGLOBULIN; UNCLASSIFIED DRUG; WILD TYPE P53 INDUCED PHOSPHATASE 1;

ARTICLE; CANCER CELL; CONTROLLED STUDY; DNA BINDING; DRUG MECHANISM; GENE AMPLIFICATION; GENE EXPRESSION; GENE FUNCTION; HUMAN; HUMAN CELL; REAL TIME POLYMERASE CHAIN REACTION; TUMOR GROWTH; ULTRAVIOLET IRRADIATION;

BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE, TUMOR; DNA PRIMERS; GENE SILENCING; HUMANS; METHYL METHANESULFONATE; NEOPLASMS; PHOSPHOPROTEIN PHOSPHATASES; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84862788880     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2012.02.013     Document Type: Article

References (45)

1. E. Batchelor, C.S. Mock, I. Bhan, A. Loewer, and G. Lahav Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage Mol Cell 30 2008 277 289 (Pubitemid 351615316)
2. D.V. Bulavin, O.N. Demidov, S. Saito, P. Kauraniemi, C. Phillips, and S.A. Amundson Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity Nat Genet 31 2002 210 225
3. Arf pathway Nat Genet 36 2004 343 350 (Pubitemid 38437256)
4. A.N. Bullock, J. Henckel, and A.R. Fersht Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy Oncogene 10 2000 1245 1256 (Pubitemid 30160617)
5. J. Chew, S. Biswas, and S. Shreeram WIP1 phosphatase is a negative regulator of NF-κB signaling Nat Cell Biol 11 2009 659 666
6. J. Choi, E. Appella, and L. Donehower The structure and expression of the murine wild- type p53-induced phosphatase 1 (Wip1) gene Genomics 64 2000 298 306 (Pubitemid 30212630)
7. J. Choi, B. Nannenga, O.N. Demidov, D.V. Bulavin, A. Cooney, and C. Brayton Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control Mol Cell Biol 22 2002 1094 1105 (Pubitemid 34094846)
8. O.N. Demidov, O. Timofeev, H.N. Lwin, C. Kek, E. Appella, and D.V. Bulavin Wip1 phosphatase regulates p53-dependent apoptosis of stem cells and tumorigenesis in the mouse intestine Cell Stem Cell 1 2007 180 190 (Pubitemid 47215589)
9. W.S. El-Deiry, S.E. Kern, J.A. Pietenpol, K.W. Kinzler, and B. Vogelstein Definition of a consensus binding site for p53 Nat Genet 11 1992 45 49
10. M. Fiscella, H. Zhang, S. Fan, K. Sakaguchi, S. Shen, and W. Mercer Wip1 a novel human protein phosphatase that is induced in response to ionizing radiation in a p53 dependent manner Proc Natl Acad Sci USA 94 1997 6048 6053 (Pubitemid 27270633)
11. H. Fujimoto, N. Onishi, N. Kato, M. Takekawa, X.Z. Xu, and A. Kosugi Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase Cell Death Differ 13 2006 1170 1180 (Pubitemid 43905597)
12. L.E. Giono, and J.J. Manfredi Mdm2 is required for inhibition of Cdk2 activity by p21, thereby contributing to p53-dependent cell cycle arrest Mol Cell Biol 27 2007 4166 4178 (Pubitemid 47011012)
13. A.R. Goloudina, K. Tanoue, A. Hammann, E. Fourmaux, X. Le Guezennec, and D.V. Bulavin Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents Proc Natl Acad Sci USA 109 2012 E68 E75
14. H.S. Han, E. Yu, J.Y. Song, J.Y. Park, S.J. Jang, and J. Choi The estrogen receptor alpha pathway induces oncogenic Wip1 phosphatase gene expression Mol Cancer Res 7 2009 713 723
15. S.L. Harris, and A.J. Levine The p53 pathway: positive and negative feedback loops Oncogene 24 2005 2899 2908 (Pubitemid 40638098)
16. Y. Haupt, R. Maya, A. Kazaz, and M. Oren Mdm2 promotes the rapid degradation of p53 Nature 387 1997 296 299 (Pubitemid 27220766)
17. T. Hershko, K. Korotayev, S. Polager, and D. Ginsberg E2F1 modulates p38 MAPK phosphorylation via transcriptional regulation of ASK1 and Wip1 J Biol Chem 281 2006 31309 31316 (Pubitemid 46041395)
18. A. Hirasawa, F. Saito-Ohara, J. Inoue, A. Hirasawa, F. Saito-Ohara, and J. Inoue Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets Clin Cancer Res 9 2003 1995 2004 (Pubitemid 36687618)
19. B.J. Kim, S.W. Ryu, and B.J. Song JNK- and p38 kinase-mediated phosphorylation of bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells J Biol Chem 281 2006 3021256 3021265
20. J. Li, Y. Yang, Y. Peng, R. Austin, W. Eyndhoven van, and K.C. Nguyen Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23 Nat Genet 2 2002 133 134
21. A. Lindqvist, M. Bruijn, L. Macurek, A. Brás, A. Mensinga, and W. Bruinsma Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression EMBO J 28 2009 3196 3206
22. P. Loukopoulos, T. Shibata, H. Katoh, A. Kokubu, M. Sakamoto, and K. Yamazaki Genome-wide array-based comparativegenomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome Cancer Sci 98 2007 392 400 (Pubitemid 46195611)
23. J.M. Lowe, H. Cha, Q. Yang, and A.J. Fornace Jr. Nuclear factor-kappaB (NF-kappaB) is a novel positive transcriptional regulator of the oncogenic Wip1 phosphatase J Biol Chem 285 2010 5249 5257
24. X. Lu, D. Bocangel, B. Nannenga, H. Yamaguchi, E. Appella, and L. Donehower The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair Mol Cell 15 2004 621 634 (Pubitemid 39141788)
25. X. Lu, O. Ma, T.A. Nguyen, S.N. Jones, M. Oren, and L.A. Donehower The Wip1 phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop Cancer Cell 4 2007 342 354 (Pubitemid 47539308)
26. X. Lu, B. Nannenga, and L. Donehower PPM1D dephosphorylates CHK1 and p53 and abrogates cell cycle checkpoints Genes Dev 19 2005 1162 1174 (Pubitemid 40696183)
27. X. Lu, T.A. Nguyen, and L.A. Donehower Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D Cell Cycle 4 2005 1060 1064 (Pubitemid 41365366)
28. X. Lu, T.A. Nguyen, X. Zhang, and A. Donehower The Wip1 phosphatase and Mdm2: cracking the Wip on p53 stability Cell Cycle 7 2008 164 168 (Pubitemid 351366515)
29. L. Macrek, A. Lindqvist, O. Voets, J. Kool, H. Vos, and R. Medema Wip1 phosphatase is associated with chromatin and dephosphorylates gamma-H2AX to promote checkpoint inhibition Oncogene 15 2010 2281 2291
30. S.H. Moon, L. Lin, X. Zhang, T.A. Nguyen, Y. Darlington, and A.S. Waldman Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair J Biol Chem 285 2010 12935 12947
31. S.H. Moon, T.A. Nguyen, Y. Darlington, X. Lu, and L.A. Donehower Dephosphorylation of gammaH2AX by WIP1: an important homeostatic regulatory event in DNA repair and cell cycle control Cell Cycle 9 2010 2092 2096
32. L. Resnick-Silverman, S. St Clair, M. Maurer, K. Zhao, and J.J. Manfredi Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53 Genes Dev 12 1998 2102 2107 (Pubitemid 28348033)
33. M. Rossi, O.N. Demidov, C.W. Anderson, E. Appella, and S.J. Mazur Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites Nucleic Acids Res 36 2008 7168 7180
34. F. Saito-Ohara, I. Imoto, J. Inoue, H. Hosoi, A. Nakagawara, and T. Sugimoto PPM1D is a potential target for 17q gain in neuroblastoma Cancer Res 63 2003 1876 1883 (Pubitemid 36460852)
35. A. Salminen, and K. Kaarniiranta Control of p53 and NF-κB signaling by Wip1 and MIF: role in cellular senescence and organismal aging Cell Signal 23 2011 747 753
36. S. Shreeram, N. Demidov, W.H. Yamaguchi, N. Onishi, C. Kek, and O.N. Timofeev Wip1 phosphatase modulates ATM-dependent signaling pathways Mol Cell 23 2006 757 764 (Pubitemid 44308587)
37. J.Y. Song, H.S. Han, K. Sabapathy, B.M. Lee, E. Yu, and J. Choi Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation J Biol Chem 19 2010 9067 9076
38. M. Takekawa, M. Adachi, A. Nakahata, I. Nakayama, F. Itoh, and H. Tsukuda p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation EMBO J 19 2000 6517 6526
39. L. Weisz, M. Oren, and V. Rotter Transcription regulation by mutant p53 Oncogene 26 2007 2202 2211 (Pubitemid 46536644)
40. A. Willis, E.J. Jung, T. Wakefield, and X. Chen Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes Oncogene 23 2004 2330 2338 (Pubitemid 38496788)
41. L. Wu, and A.J. Levine Differential regulation of the p21/WAF-1 and mdm2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the mdm2 gene Mol Med 3 1997 441 451 (Pubitemid 27438768)
42. Y. Xia, P. Ongusaha, S.W. Lee, and Y.C. Liou Loss of Wip1 sensitizes cells to stress- and DNA damage-induced apoptosis J Biol Chem 284 2009 17428 17437
43. H. Yamaguchi, G. Minopoli, O. Demidov, D. Chatterjee, C. Anderson, and S. Durell Substrate specificity of the human protein phosphatase 2C delta, Wip1 Biochemistry 44 2005 5285 5294 (Pubitemid 40489968)
44. E. Yu, Y.S. Ahn, S.J. Jang, M.J. Kim, H.S. Yoon, and G. Gong Overexpression of the wip1 gene abrogates the p38 MAPK/p53/Wip1 pathway and silences p16 expression in human breast cancers Breast Cancer Res Treat 101 2007 269 278 (Pubitemid 46169880)
45. X. Zhang, L. Lin, H. Guo, J. Yang, N.S. Jones, and A. Jochemsen Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response Cancer Res 69 2009 7960 7998