Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: Identification of genetic indicators that predict patient outcome

Cancer Science

Volumn 98, Issue 3, 2007, Pages 392-400

  Loukopoulos, Panayiotis ^a,f   Shibata, Tatsuhiro ^a   Katoh, Hiroto ^a   Kokubu, Akiko ^a   Sakamoto, Michiie ^b   Yamazaki, Ken ^b   Kosuge, Tomoo ^c   Kanai, Yae ^a   Hosoda, Fumie ^a   Imoto, Issei ^d,e   Ohki, Misao ^a   Inazawa, Jyoji ^d,e   Hirohashi, Setsuo ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NATIONAL CANCER CENTER HOSPITAL   (Japan)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^f ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE 3B; HEMATOPOIETIC CELL KINASE; ONCOPROTEIN; PROTEIN BCAS1; PROTEIN LUNX; PROTEIN PPM1D; PROTEIN SMURF1; PROTEIN TRRAP; PROTEIN VCL; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

ARTICLE; CANCER INVASION; CARCINOGENESIS; CHROMOSOME 10Q; CHROMOSOME 11P; CHROMOSOME 11Q; CHROMOSOME 12P; CHROMOSOME 13Q; CHROMOSOME 14Q; CHROMOSOME 15Q; CHROMOSOME 16P; CHROMOSOME 17P; CHROMOSOME 17Q; CHROMOSOME 18Q; CHROMOSOME 19P; CHROMOSOME 1P; CHROMOSOME 1Q; CHROMOSOME 21Q; CHROMOSOME 22Q; CHROMOSOME 2P; CHROMOSOME 2Q; CHROMOSOME 3Q; CHROMOSOME 4P; CHROMOSOME 5P; CHROMOSOME 5Q; CHROMOSOME 7P; CHROMOSOME 7Q; CHROMOSOME 8P; CHROMOSOME 8Q; CHROMOSOME 9Q; CHROMOSOME LOSS; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE LOCUS; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MALE; NUMERICAL CHROMOSOME ABERRATION; PANCREAS ADENOCARCINOMA; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; PROGNOSIS;

ADENOCARCINOMA; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME, HUMAN; HUMANS; HYBRIDIZATION, GENETIC; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PANCREATIC NEOPLASMS; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL RATE;

EID: 33846653317     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2007.00395.x     Document Type: Article

References (45)

1. Conlon KC, Klimstra DS, Brennan MF. Long-term survival after curative resection for pancreatic ductal adenocarcinoma. Clinicopathologic analysis of 5-year survivors. Ann Surg 1996; 223: 273-9.
2. Torrisani J, Buscail L. Molecular pathways of pancreatic carcinogenesis. Ann Pathol 2002; 22: 349-55.
3. Kallioniemi A, Kallioniemi OP, Sudar D et al. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 1992; 258: 818-21.
4. Johansson B, Bardi G, Heim S et al. Nonrandom chromosomal rearrangements in pancreatic carcinomas. Cancer 1992; 69: 1674-81.
5. Bardi G, Johansson B, Pandis N et al. Karyotypic abnormalities in tumours of the pancreas. Br J Cancer 1993; 67: 1106-12.
6. Hahn SA, Seymour AB, Hoque AT et al. Allelotype of pancreatic adenocarcinoma using xenograft enrichment. Cancer Res 1995; 55: 4670-5.
7. Armengol G, Knuutila S, Lluis F, Capella G, Miro R, Caballin MR. DNA copy number changes and evaluation of MYC, IGF1R, and FES amplification in xenografts of pancreatic adenocarcinoma. Cancer Genet Cytogenet 2000; 116: 133-41.
8. Griffin CA, Hruban RH, Morsberger LA et al. Consistent chromosome abnormalities in adenocarcinoma of the pancreas. Cancer Res 1995; 55: 2394-9.
9. Mahlamaki EH, Hoglund M, Gorunova L et al. Comparative genomic hybridization reveals frequent gains of 20q, 8q, 11q, 12p, and 17q, and losses of 18q, 9p, and 15q in pancreatic cancer. Genes Chromosomes Cancer 1997; 20: 383-91.
10. Schleger C, Arens N, Zentgraf H, Bleyl U, Verbeke C. Identification of frequent chromosomal aberrations in ductal adenocarcinoma of the pancreas by comparative genomic hybridization (CGH). J Pathol 2000; 191: 27-32.
11. Heidenblad M, Jonson T, Mahlamaki EH et al. Detailed genomic mapping and expression analyses of 12p amplifications in pancreatic carcinomas reveal a 3.5-Mb target region for amplification. Genes Chromosomes Cancer 2002; 34: 211-23.
12. Gorunova L, Hoglund M, Andren-Sandberg A et al. Cytogenetic analysis of pancreatic carcinomas: Intratumor heterogeneity and nonrandom pattern of chromosome aberrations. Genes Chromosomes Cancer 1998; 23: 81-99.
13. Heidenblad M, Schoenmakers EF, Jonson T et al. Genome-wide array-based comparative genomic hybridization reveals multiple amplification targets and novel homozygous deletions in pancreatic carcinoma cell lines. Cancer Res 2004; 64: 3052-9.
14. Aguirre AJ, Brennan C, Bailey G et al. High-resolution characterization of the pancreatic adenocarcinoma genome. Proc Natl Acad Sci USA 2004; 101: 9067-72.
15. Holzmann K, Kohlhammer H, Schwaenen C et al. Genomic DNA-chip hybridization reveals a higher incidence of genomic amplifications in pancreatic cancer than conventional comparative genomic hybridization and leads to the identification of novel candidate genes. Cancer Res 2004; 64: 4428-33.
16. Bashyam MD, Bair R, Kim YH et al. Array-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancer. Neoplasia 2005; 7: 556-62.
17. Gysin S, Rickert P, Kastury K, McMahon M. Analysis of genomic DNA alterations and mRNA expression patterns in a panel of human pancreatic cancer cell lines. Genes Chromosomes Cancer 2005; 44: 37-51.
18. Mahlamaki EH, Kauraniemi P, Monni O, Wolf M, Hautaniemi S, Kallioniemi A. High-resolution genomic and expression profiling reveals 105 putative amplification target genes in pancreatic cancer. Neoplasia 2004; 6: 432-9.
19. Nowak NJ, Gaile D, Conroy JM et al. Genome-wide aberrations in pancreatic adenocarcinoma. Cancer Genet Cytogenet 2005; 161: 36-50.
20. Loukopoulos P, Kanetaka K, Takamura M, Shibata T, Sakamoto M, Hirohashi S. Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity. Pancreas 2004; 29: 193-203.
21. Japan Pancreas Society. Classification of Pancreatic Carcinoma, 2nd English edn. Tokyo: Kanehara and Co., 2003.
22. Tanabe C, Aoyagi K, Sakiyama T et al. Evaluation of a whole-genome amplification method based on adaptor-ligation PCR of randomly sheared genomic DNA. Genes Chromosomes Cancer 2003; 38: 168-76.
23. Sonoda I, Imoto I, Inoue J et al. Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma. Cancer Res 2004; 64: 3741-7.
24. Takada H, Imoto I, Tsuda H et al. Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization. Cancer Sci 2005; 96: 100-10.
25. Peng W-X, Shibata T, Katoh H et al. Array-based comparative genomic hybridization analysis of high-grade neuroendocrine tumors of the lung. Cancer Sci 2005; 96: 661-7.
26. Katoh H, Shibata T, Kokubu A et al. Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization: Identification of genetic indicators to predict patient outcome. J Hepatol 2005; 43: 863-74.
27. Yamazaki K, Sakamoto M, Ohta T, Kanai Y, Ohki M, Hirohashi S. Overexpression of KIT in chromophobe renal cell carcinoma. Oncogene 2003; 22: 847-52.
28. Tanno S, Mitsuuchi Y, Altomare DA, Xiao GH, Testa JR. AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells. Cancer Res 2001; 61: 589-93.
29. Kitoh H, Ryozawa S, Harada T et al. Comparative genomic hybridization analysis for pancreatic cancer specimens obtained by endoscopic ultrasonography-guided fine-needle aspiration. J Gastroenterol 2005; 40: 511-17.
30. Iacobuzio-Donahue CA, van der Heijden MS, Baumgartner MR et al. Large-scale allelotype of pancreaticobiliary carcinoma provides quantitative estimates of genome-wide allelic loss. Cancer Res 2004; 64: 871-5.
31. Iwao K, Watanabe T, Fujiwara Y et al. Isolation of a novel human lung-specific gene, LUNX, a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Int J Cancer 2001; 91: 433-7.
32. Phillips AC, Ernst MK, Bates S, Rice NR, Vousden KH. E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways. Mol Cell 1999; 4: 771-81.
33. Girault I, Tozlu S, Lidereau R, Bieche I. Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas. Clin Cancer Res 2003; 9: 4415-22.
34. Friess H, Lu Z, Andren-Sandberg A et al. Moderate activation of the apoptosis inhibitor bcl-xL worsens the prognosis in pancreatic cancer. Ann Surg 1998; 228: 780-7.
35. Ghaneh P, Kawesha A, Evans JD, Neoptolemos JP. Molecular prognostic markers in pancreatic cancer. J Hepatobiliary Pancreat Surg 2002; 9: 1-11.
36. Heidenblad M, Lindgren D, Veltman JA et al. Microarray analyses reveal strong influence of DNA copy number alterations on the transcriptional patterns in pancreatic cancer: Implications for the interpretation of genomic amplifications. Oncogene 2005; 24: 1794-801.
37. Matsumoto H, Matsuyama H, Fukunaga K, Yoshihiro S, Wada T, Naito K. Allelic imbalance at 1p36 may predict prognosis of chemoradiation therapy for bladder preservation in patients with invasive bladder cancer. Br J Cancer 2004; 91: 1025-31.
38. Li J, Yang Y, Peng Y et al. Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nat Genet 2002; 31: 133-4.
39. Hirasawa A, Saito-Ohara F, Inoue J et al. Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets. Clin Cancer Res 2003; 9: 1995-2004.
40. Hyman E, Kauraniemi P, Hautaniemi S et al. Impact of DNA amplification on gene expression patterns in breast cancer. Cancer Res 2002; 62: 6240-5.
41. Pollack JR, Sorlie T, Perou CM et al. Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors. Proc Natl Acad Sci USA 2002; 99: 12963-8.
42. Platzer P, Upender MB, Wilson K et al. Silence of chromosomal amplifications in colon cancer. Cancer Res 2002; 62: 1134-8.
43. Zhu H, Kavsak P, Abdollah S, Wrana JL, Thomsen GH. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 1999; 400: 687-93.
44. Collins C, Rommens JM, Kowbel D et al. Positional cloning of ZNF217 and NABC1: Genes amplified at 20q13.2 and overexpressed in breast carcinoma. Proc Natl Acad Sci USA 1998; 95: 8703-8.
45. Bakolitsa C, Cohen DM, Bankston LA et al. Structural basis for vinculin activation at sites of cell adhesion. Nature 2004; 430: 583-6.