Lithium attenuates bupivacaine-induced neurotoxicity in vitro through phosphatidylinositol-3-kinase/threonine-serine protein kinase B- and extracellular signal-regulated kinase-dependent mechanisms

Neuroscience

Volumn 206, Issue , 2012, Pages 190-200

  Wang, Z ^a   Shen, J ^a   Wang, J ^a   Lu, T ^a   Li, C ^b   Zhang, X ^a   Liu, L ^a   Ding, Z ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b East Tennessee State University   (United States)

Author keywords

Akt signaling; ERK signaling; Lithium; Local anesthetics; Neurotoxicity; PI3K

Indexed keywords

BUPIVACAINE; LITHIUM CHLORIDE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG SAFETY; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME INHIBITION; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; NUCLEAR CONDENSATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANESTHETICS, LOCAL; ANIMALS; BLOTTING, WESTERN; BUPIVACAINE; CELL LINE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; LITHIUM CHLORIDE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXICITY SYNDROMES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84862786089     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2011.12.043     Document Type: Article

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