Definition of metabolism-dependent xenobiotic toxicity with co-cultures of human hepatocytes and mouse 3T3 fibroblasts in the novel integrated discrete multiple organ co-culture (IdMOC) experimental system: Results with model toxicants aflatoxin B1, cyclophosphamide and tamoxifen

Chemico-Biological Interactions

Volumn 199, Issue 1, 2012, Pages 1-8

  Li, Albert P ^a   Uzgare, Aarti ^a   Laforge, Yumiko S ^a  

^a ADMET Laboratories LLC   (United States)

Author keywords

Animal alternatives; Detoxification; Human hepatocytes; In vitro toxicology; Metabolic activation

Indexed keywords

AFLATOXIN B1; CYCLOPHOSPHAMIDE; TAMOXIFEN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL TYPE; CONTROLLED STUDY; CULTURE TECHNIQUE; CYTOTOXICITY TEST; FIBROBLAST; HUMAN; HUMAN CELL; IC 50; INTEGRATED DISCRETE MULTIPLE ORGAN CO CULTURE SYSTEM; LIVER CELL; LIVER METABOLISM; METABOLIC ACTIVATION; NONHUMAN; XENOBIOTIC METABOLISM;

3T3 CELLS; ACETALS; AFLATOXIN B1; ANIMALS; COCULTURE TECHNIQUES; CYCLOPHOSPHAMIDE; CYTOCHROME P-450 ENZYME SYSTEM; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FIBROBLASTS; FIREFLY LUCIFERIN; HEPATOCYTES; HUMANS; INHIBITORY CONCENTRATION 50; METABOLIC DETOXICATION, DRUG; MICE; TAMOXIFEN; TOXICITY TESTS; TRIAZOLES; XENOBIOTICS;

ANIMALIA;

EID: 84862698688     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.05.003     Document Type: Article

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