Cytochrome P450 2E1 metabolically activates propargyl alcohol: Propiolaldehyde-induced hepatocyte cytotoxicity

Chemico-Biological Interactions

Volumn 130-132, Issue , 2001, Pages 931-942

  Moridani, Majid Y ^a   Khan, Sumsullah ^a   Chan, Tom ^a   Teng, Shirley ^a   Beard, Kristin ^a   O'Brien, Peter J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Aldehydes; Cytochrome P450; Hepatocytes; Pargyline; Propargyl alcohol

Indexed keywords

ALCOHOL DERIVATIVE; ALDEHYDE DERIVATIVE; CATALASE; CYTOCHROME P450 2E1; DEFEROXAMINE; DITHIOTHREITOL; GLUTATHIONE; HYDROGEN PEROXIDE; PARGYLINE; PROPARGYL ALCOHOL; PROPIOLALDEHYDE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ALCOHOL METABOLISM; ANIMAL CELL; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVATION; GLUTATHIONE METABOLISM; LIVER MICROSOME METABOLISM; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; RAT;

ALDEHYDES; ALKYNES; ANIMALS; BIOTRANSFORMATION; CELL SURVIVAL; CYTOCHROME P-450 CYP2E1; GLUTATHIONE; HEPATOCYTES; LIPID PEROXIDATION; MALE; PROPANOLS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0035969852     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(00)00246-5     Document Type: Conference Paper

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