Evaluation of luciferin-isopropyl acetal as a CYP3A4 substrate for human hepatocytes: Effects of organic solvents, cytochrome P450 (P450) inhibitors, and P450 inducers

Drug Metabolism and Disposition

Volumn 37, Issue 8, 2009, Pages 1598-1603

  Li, Albert P ^a  

^a In Vitro ADMET Laboratories LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINOBENZOTRIAZOLE; 3 METHYLCHOLANTHRENE; ACETAL DERIVATIVE; ACETONITRILE; CARBAMAZEPINE; COMPLEMENTARY DNA; CYTOCHROME P450 3A4; DIETHYLDITHIOCARBAMIC ACID; DIMETHYL SULFOXIDE; FURAFYLLINE; ISOPROPYL ACETAL; KETOCONAZOLE; LUCIFERIN; METHANOL; OMEPRAZOLE; ORGANIC SOLVENT; ORPHENADRINE; PHENOBARBITAL; PHENYTOIN; QUINIDINE; RIFAMPICIN; SULFAPHENAZOLE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG METABOLISM; ENZYME INDUCTION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; LIVER CELL; METABOLIC INHIBITION; MICHAELIS MENTEN KINETICS; PRIORITY JOURNAL;

ACETALS; CELLS, CULTURED; CRYOPRESERVATION; CYTOCHROME P-450 CYP3A; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; ENZYME INHIBITORS; FEMALE; FIREFLY LUCIFERIN; HEPATOCYTES; HUMANS; KINETICS; MIDDLE AGED; SOLVENTS; SUBSTRATE SPECIFICITY;

EID: 67650792478     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.027268     Document Type: Article

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