Structural influence of isothiocyanates on expression of cytochrome P450, phase II enzymes, and activation of Nrf2 in primary rat hepatocytes

Food and Chemical Toxicology

Volumn 50, Issue 8, 2012, Pages 2822-2830

  La Marca, M ^a   Beffy, P ^b   Della Croce, C ^a   Gervasi, P G ^b   Iori, R ^c   Puccinelli, E ^b   Longo, V ^a  

^a Institute of Agricultural Biology and Biotechnology   (Italy)

^b CNR   (Italy)

^c ISTITUTO NAZIONALE DELLA NUTRIZIONE   (Italy)

Author keywords

Cytochrome 450; Isothiocyanate; Nrf2; Oxidative stress; Phase II

Indexed keywords

ALLYL ISOTHIOCYANATE; ANTIOXIDANT; BENZYL ISOTHIOCYANATE; BENZYLOXYQUINOLINE DEBENZYLASE; CATALASE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 3A2; ETHOXYRESORUFIN DEETHYLASE; GLUTATHIONE TRANSFERASE; HEME OXYGENASE 1; IBCRIN ISOTHIOCYANATE; ISOTHIOCYANIC ACID DERIVATIVE; NAPIN ISOTHIOCYANATE; PHENETHYL ISOTHIOCYANATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); RHAPHASATIN ISOTHIOCYANATE; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG STRUCTURE; ENZYME INHIBITION; GENE INDUCTION; GENE REPRESSION; HYDROPHILICITY; LIVER CELL; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; UPREGULATION;

ANIMALS; BASE SEQUENCE; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; ENZYME ACTIVATION; HEPATOCYTES; ISOTHIOCYANATES; MALE; NF-E2-RELATED FACTOR 2; POLYMERASE CHAIN REACTION; RATS; RATS, WISTAR;

RATTUS;

EID: 84862689618     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.05.044     Document Type: Article

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