α-lipoic acid inhibits high glucose-induced apoptosis in HIT-T15 cells

Development Growth and Differentiation

Volumn 54, Issue 5, 2012, Pages 557-565

  Yang, Yi ^a,b   Wang, Weiping ^a   Liu, Yinan ^a   Guo, Ting ^a   Chen, Ping ^a   Ma, Kangtao ^a   Zhou, Chunyan ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b NINGXIA MEDICAL UNIVERSITY   (China)

Author keywords

lipoic acid; Apoptosis; Diabetes; Islet beta cells; Pdx1

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; GLUCOSE; INSULIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; THIOCTIC ACID; TRANSCRIPTION FACTOR PDX 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; GENE EXPRESSION; INSULIN RELEASE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN PHOSPHORYLATION; UPREGULATION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-ASSOCIATED DEATH PROTEIN; CELL LINE; CELL PROLIFERATION; CHROMONES; CRICETINAE; CYTOPROTECTION; DIABETES MELLITUS; GLUCOSE; HOMEODOMAIN PROTEINS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MORPHOLINES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; THIOCTIC ACID; TRANS-ACTIVATORS;

EID: 84862649598     PISSN: 00121592     EISSN: 1440169X     Source Type: Journal    
DOI: 10.1111/j.1440-169X.2012.01356.x     Document Type: Article

References (32)

1. Abdin, A. & Sarhan, N. 2011. Intervention of mitochondrial dysfunction-oxidative stress-dependent apoptosis as a possible neuroprotective mechanism of α-lipoic acid against rotenone-induced parkinsonism and L-dopa toxicity. Neurosci. Res. 71, 387-395.
2. Artwohl, M., Muth, K., Kosulin, K., de Martin, R., Holzenbein, T., Rainer, G., Freudenthaler, A., Huttary, N., Schmetterer, L., Waldhausl, W. K. & Baumgartner-Parzer, S. M. 2007. R-(+)-alpha-lipoic acid inhibits endothelial cell apoptosis and proliferation: involvement of Akt and retinoblastoma protein/E2F-1. Am. J. Physiol. Endocrinol. Metab. 293, E681-E689.
3. Balkis, B. S., Othman, F., Louis, S. R., Abu, B. M., Radzi, M., Osman, K., Das, S. & Mohamed, J. 2009. Effect of alpha lipoic acid on oxidative stress and vascular wall of diabetic rats. Rom. J. Morphol. Embryol. 50, 23-30.
4. Byun, C. H., Koh, J. M., Kim, D. K., Park, S. I., Lee, K. U. & Kim, G. S. 2005. Alpha-lipoic acid inhibits TNF-alpha-induced apoptosis in human bone marrow stromal cells. J. Bone Miner. Res. 20, 1125-1130.
5. Choi, S. Y., Yu, J. H. & Kim, H. 2009. Mechanism of alpha-lipoic acid-induced apoptosis of lung cancer cells. Ann. N. Y. Acad. Sci. 1171, 149-155.
6. Dickson, L. M. & Rhodes, C. J. 2004. Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt? Am. J. Physiol. Endocrinol. Metab. 287, E192-E198.
7. Diesel, B., Kulhanek-Heinze, S., Holtje, M., Brandt, B., Holtje, H. D., Vollmar, A. M. & Kiemer, A. K. 2007. Alpha-lipoic acid as a directly binding activator of the insulin receptor: protection from hepatocyte apoptosis. Biochemistry 46, 2146-2155.
8. Fujimoto, K. & Polonsky, K. S. 2009. Pdx1 and other factors that regulate pancreatic beta-cell survival. Diabetes Obes. Metab. 11(Suppl 4), 30-37.
9. Fujimoto, K., Hanson, P. T., Tran, H., Ford, E. L., Han, Z., Johnson, J. D., Schmidt, R. E., Green, K. G., Wice, B. M. & Polonsky, K. S. 2009. Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation. J. Biol. Chem. 284, 27664-27673.
10. Gauthier, B. R., Wiederkehr, A., Baquie, M., Dai, C., Powers, A. C., Kerr-Conte, J., Pattou, F., MacDonald, R. J., Ferrer, J. & Wollheim, C. B. 2009. PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression. Cell Metab. 10, 110-118.
11. Goraca, A., Huk-Kolega, H., Piechota, A., Kleniewska, P., Ciejka, E. & Skibska, B. 2011. Lipoic acid - biological activity and therapeutic potential. Pharmacol. Rep. 63, 849-858.
12. Guo, T., Wang, W. P., Zhang, H., Liu, Y. N., Chen, P., Ma, K. T. & Zhou, C. Y. 2011. ISL1 promotes pancreatic islet cell proliferation. PLoS ONE 6, e22387.
13. Gupte, A. A., Bomhoff, G. L., Morris, J. K., Gorres, B. K. & Geiger, P. C. 2009. Lipoic acid increases heat shock protein expression and inhibits stress kinase activation to improve insulin signaling in skeletal muscle from high-fat-fed rats. J. Appl. Physiol. 106, 1425-1434.
14. Johnson, J. D., Ahmed, N. T., Luciani, D. S., Han, Z., Tran, H., Fujita, J., Misler, S., Edlund, H. & Polonsky, K. S. 2003. Increased islet apoptosis in Pdx1+/- mice. J. Clin. Invest. 111, 1147-1160.
15. Kamenova, P. 2006. Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid. Hormones (Athens) 5, 251-258.
16. Lee, S. J., Kim, S. H., Kang, J. G., Kim, C. S., Ihm, S. H., Choi, M. G. & Yoo, H. J. 2011. Alpha-lipoic acid inhibits endoplasmic reticulum stress-induced cell death through PI3K/Akt signaling pathway in FRTL5 thyroid cells. Horm. Metab. Res. 43, 445-451.
17. Lee, W. J., Song, K. H., Koh, E. H., Won, J. C., Kim, H. S., Park, H. S., Kim, M. S., Kim, S. W., Lee, K. U. & Park, J. Y. 2005. Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle. Biochem. Biophys. Res. Commun. 332, 885-891.
18. Li, Y., Cao, X. Li, X. L., Brubaker, P. L., Edlund, H. & Drucker, D. J. 2005. beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1. Diabetes 54, 482-491.
19. Meng, X., Li, Z. M., Zhou, Y. J., Cao, Y. L. & Zhang, J. 2008. Effect of the antioxidant alpha-lipoic acid on apoptosis in human umbilical vein endothelial cells induced by high glucose. Clin. Exp. Med. 8, 43-49.
20. Muellenbach, E. M., Diehl, C. J., Teachey, M. K., Lindborg, K. A., Hasselwander, O., Matuschek, M. & Henriksen, E. J. 2009. Metabolic interactions of AGE inhibitor pyridoxamine and antioxidant alpha-lipoic acid following 22 weeks of treatment in obese Zucker rats. Life Sci. 84, 563-568.
21. Piconi, L., Quagliaro, L., Assaloni, R., Da, R. R., Maier, A., Zuodar, G. & Ceriello, A. 2006. Constant and intermittent high glucose enhances endothelial cell apoptosis through mitochondrial superoxide overproduction. Diabetes Metab. Res. Rev. 22, 198-203.
22. Robertson, R., Zhang, H., Pyzdrowski, K. & Walseth, T. 1992. Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations. J. Clin. Invest. 90, 320-325.
23. Salinthone, S., Yadav, V., Schillace, R. V., Bourdette, D. N. & Carr, D. W. 2010. Lipoic acid attenuates inflammation via cAMP and protein kinase A signaling. PLoS ONE 28, pii: e13058.
24. Shay, K. P. & Hagen, T. M. 2009. Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A. Biogerontology 10, 443-456.
25. Shi, D. Y., Liu, H. L., Stern, J. S., Yu, P. Z. & Liu, S. L. 2008. Alpha-lipoic acid induces apoptosis in hepatoma cells via the PTEN/Akt pathway. FEBS Lett. 582, 1667-1671.
26. Tanaka, Y., Tran, P. O., Harmon, J. & Robertson, R. P. 2002. A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity. Proc. Natl Acad. Sci. USA 99, 12363-12368.
27. Targonsky, E., Dai, F., Koshkin, V., Karaman, G., Gyulkhandanyan, A., Zhang, Y., Chan, C. & Wheeler, M. 2006. Alpha-lipoic acid regulates AMP-activated protein kinase and inhibits insulin secretion from beta cells. Diabetologia 49, 1587-1598.
28. Varkonyi, T. & Kempler, P. 2008. Diabetic neuropathy: new strategies for treatment. Diabetes Obes. Metab. 10, 99-108.
29. Wang, H. W., Mizuta, M., Saitoh, Y., Noma, K., Ueno, H. & Nakazato, M. 2011a. Glucagon-like peptide-1 and candesartan additively improve glucolipotoxicity in pancreatic β-cells. Metabolism 60, 1081-1089.
30. Wang, X., Liu, Y., Yang, Z., Zhang, Z., Zhou, W., Ye, Z., Zhang, W., Zhang, S., Yang, Z., Feng, X., Chen, F. & Hu, R. 2011b. Glucose metabolism-related protein 1 (GMRP1) regulates pancreatic beta cell proliferation and apoptosis via activation of Akt signalling pathway in rats and mice. Diabetologia 54, 852-863.
31. Wang, Y., Li, X., Guo, Y., Chan, L. & Guan, X. 2010. alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged mice. Metabolism 59, 967-976.
32. Weir, G. C., Laybutt, D. R., Kaneto, H., Bonner-Weir, S. & Sharma, A. 2001. Beta-cell adaptation and decompensation during the progression of diabetes. Diabetes 50, S154-S159.