Dukes C colorectal cancer: Is the metastatic lymph node ratio important?

International Journal of Colorectal Disease

Volumn 27, Issue 3, 2012, Pages 309-317

  Thomas, Matthew ^a   Biswas, Somita ^a   Mohamed, Faheez ^b   Chandrakumaran, Kandiah ^b   Jha, Madan ^a   Wilson, Robert ^a  

^a JAMES COOK UNIVERSITY HOSPITAL   (United Kingdom)

^b BASINGSTOKE AND NORTH HAMPSHIRE HOSPITAL   (United Kingdom)

Author keywords

Colorectal cancer; Lymph node; Staging; Survival

Indexed keywords

ANTINEOPLASTIC AGENT; FLUOROURACIL;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; COLORECTAL CANCER; COLORECTAL SURGERY; DEMOGRAPHY; FEMALE; HISTOPATHOLOGY; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; ADJUVANT CHEMOTHERAPY; COLON TUMOR; KAPLAN MEIER METHOD; LYMPH NODE; LYMPHADENECTOMY; MIDDLE AGED; MULTIVARIATE ANALYSIS; PATHOLOGY; RECTUM TUMOR;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; CHEMOTHERAPY, ADJUVANT; COLONIC NEOPLASMS; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; LYMPH NODE EXCISION; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; RECTAL NEOPLASMS;

EID: 84862591343     PISSN: 01791958     EISSN: 14321262     Source Type: Journal    
DOI: 10.1007/s00384-011-1340-3     Document Type: Article

References (39)

1. Jemal A, Murray T, Samuels A et al (2003) Cancer statistics, 2003. CA Cancer J Clin 53:5-26
2. Sobin LH, Wittekind C (eds) (2002) International Union Against Cancer-TNM classification of malignant tumours, 6th edn. Wiley, NewYork
3. Chang GJ, Rodriguez-Bigas MA, Skibber JM, Moyer VA (2007) Lymph node evaluation and survival after curative resection of colon cancer: systematic review. J Natl Cancer Inst 99:433-441
4. Compton CC, Fielding LP, Burgart LJ et al (2000) Prognostic factors in colorectal cancer: College of American Pathologists consensus statement 1999. Arch Pathol Lab Med 124:979-994
5. Association of ColoproctologyGreat Britain and Ireland (2007) Guidelines for the management of colorectal cancer. 3rd ed. Association of ColoproctologyGreat Britain and Ireland.
6. Chen S, Bilchik A (2006) More extensive nodal dissection improves survival for stages I to III of colon cancer: a population-based study. Ann Surg 244:602-610
7. Joseph NE, Sigurdson ER, Hanlon AL et al (2003) Accuracy of determining nodal negativity in colorectal cancer on the basis of the number of nodes retrieved on resection. Ann Surg Oncol 10:213-218
8. Wang J, Kulaylat M, Rockette H et al (2009) Should total number of lymph nodes be used as a quality of care measure for stage III colon cancer? Ann Surg 249:559-563
9. Truong PT, Vinh-Hung V, Cserni G, Woodward WA, Tai P, Vlastos G (2008) The number of positive nodes and the ratio of positive to excised nodes are significant predictors of survival in women with micrometastatic node-positive breast cancer. Eur J Cancer 44:1670-1677
10. Herr HW (2003) Superiority of ratio based lymph node staging for bladder cancer. J Urol 169:943-945
11. Pawlik TM, Gleisner AL, Cameron JL et al (2007) Prognostic relevance of lymph node ratio following pancreaticoduodenec-tomy for pancreatic cancer. Surgery 141:610-618
12. Marchet A, Mocellin S, Ambrosi A et al (2007) The ratio between metastatic and examined lymph nodes is an independent prognostic factor in gastric cancer regardless of the type of lymphadenectomy: results from an Italian multicentre study in 1853 patients. Ann Surg 245:543-552
13. Berger A, Sigurdson E, LeVoyer T et al (2005) Colon cancer survival is associated with decreasing ratio of metastatic to examined lymph nodes. J Clin Oncol 23:8706-8712
14. Vaccaro CA, Im V, Rossi GL et al (2009) Lymph node ratio as prognosis factor for colon cancer treated by colorectal surgeons. Dis Colon Rectum 52:1244-1250
15. Chin CC, Wang JY, Kuo YH, Huang WS, Yeh CH (2009) Metastatic lymph node ratio is a more precise predictor of prognosis than number of lymph node metastases in stage III colon cancer. Int J Colorectal Dis 24:1297-1302
16. Derwinger K, Carlsson G, Gustavsson B (2008) A study of lymph node ratio as a prognostic marker in colon cancer. Eur J Surg Oncol 34:771-775
17. Pescaud F, Benoist S, Julie C et al (2008) The ratio of metastatic to examined lymph nodes is a powerful prognostic factor in rectal cancer. Ann Surg 248:1067-1073
18. Rosenburg R, Friederichs J, Schuster T et al (2008) Prognosis of patients with colorectal cancer is associated with lymph node ratio: a single-centre analysis of 3026 patients over a 25 year time period. Ann Surg 248:968-978
19. Galizia G, Orditura M, Ferraraccio F et al (2009) The lymph node ratio is a powerful prognostic factor of node-positive colon cancers undergoing potentially curative surgery. World J Surg 33:2704-2713
20. Wang J, Hassett JM, Dayton MT, Kulaylat MN (2008) Lymph node ratio: role in the staging of node-positive colon cancer. Ann Surg Oncol 15:1600-1608
21. Morcos B, Baker B, Al-Masri M, Haddad H, Hashem S (2010) Lymph node yield in rectal cancer surgery: effect of preoperative chemoradiotherapy. Eur J Surg Oncol 36:345-349
22. Kang J, Hur H, Min BS, Lee KY, Kim NK (2011) Prognostic impact of the lymph node ratio in rectal cancer patients who underwent preoperative chemoradiation. J Surg Oncol 104:53-58
23. Bilchik AJ, Nora DT, Sobin LH et al (2003) Effect of lymphatic mapping on the new tumor-node-metastasis classification for colorectal cancer. J Clin Oncol 21:668-672
24. Compton C (2007) Optimal pathological staging: defining stage II disease. Clin Cancer Res 13(22):6862-6870
25. Klos CL, Bordeianou LG, Sylla P, Chang Y, Berger DL (2011) The prognostic value of lymph node ratio after neoadjuvant chemo-radiation and rectal cancer surgery. Dis Colon Rectum 54:171-175
26. Huh JW, Kim YJ, Kim HR (2010) Ratio of metastatic to resected lymph nodes as a prognostic factor in node-positive colorectal cancer. Ann Surg Oncol 17:2640-2646
27. Ainsworth PD, Johnson MA (2010) The prognostic significance of the metastatic lymph node ratio in Dukes stage C colorectal cancer in a district general hospital. Colorectal Dis 12:1219-1222
28. th edition of the TNM classification. Eur J Surg Oncol 36:1180-1186
29. Rosenberg R, Engel J, Bruns C et al (2010) The prognostic value of lymph node ratio in a population-based collective of colorectal cancer patients. Ann Surg 251:1070-1078
30. Park IJ, Choi GS, Jun SH (2009) Nodal stage of stage III colon cancer: the impact of the metastatic lymph node ratio. J Surg Oncol 100:240-243
31. Priolli DG, Cardinalli IA, Pereira JA, Alfredo CH, Margarido NF, Martinez CA (2009) Metastatic lymph node ratio as an independent prognostic variable in colorectal cancer: study of 113 patients. Tech Coloproctol 13:113-121
32. Kim YS, Kim JH, Yoon SM et al (2009) Lymph node ratio as a prognostic factor in patients with stage III rectal cancer treated with total mesorectal excision followed by chemoradiotherapy. Int J Radiat Oncol Biol Phys 74:796-802
33. Vather R, Sammour T, Kahokehr A, Connolly AB, Hill AG (2009) Lymph node evaluation and long-term survival in stage II and stage III colon cancer: a national study. Ann Surg Oncol 16:585-593
34. Moug SJ, Saldanha JD, McGregor JR, Balsitis M, Diament RH (2009) Positive lymph node retrieval ratio optimises patient staging in colorectal cancer. Br J Cancer 100:1530-1533
35. Derwinger K, Gustavsson B (2008) A study of lymph node ratio in stage IV colorectal cancer. World J Surg Oncol 6:127
36. Peng J, Xu Y, Guan Z et al (2008) Prognostic significance of the metastatic lymph node ratio in node-positive rectal cancer. Ann Surg Oncol 15:3118-3123
37. Schumacher P, Dineen S, Barnett C Jr, Fleming J, Anthony T (2007) The metastatic lymph node ratio predicts survival in colon cancer. Am J Surg 194:827-831
38. Lee HY, Choi HJ, Park KJ et al (2007) Prognostic significance of metastatic lymph node ratio in node-positive colon carcinoma. Ann Surg Oncol 14:1712-1717
39. De Ridder M, Vinh-Hung V, Van Nieuwenhove Y, Hoorens A, Sermeus A, Storme G (2006) Prognostic value of the lymph node ratio in node positive colon cancer. Gut 55:1681