Prognostic impact of the lymph node ratio in rectal cancer patients who underwent preoperative chemoradiation

Journal of Surgical Oncology

Volumn 104, Issue 1, 2011, Pages 53-58

  Kang, Jeonghyun ^a   Hur, Hyuk ^b   Min, Byung Soh ^b   Lee, Kang Young ^b   Kim, Nam Kyu ^b  

^a Gachon University College of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

Lymph node ratio; Preoperative chemoradiation; Rectal cancer; ypN stage

Indexed keywords

ADULT; ARTICLE; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CHEMORADIOTHERAPY; CONTROLLED STUDY; FEMALE; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PREOPERATIVE RADIOTHERAPY; PRIORITY JOURNAL; PROGNOSIS; RECTUM ABDOMINOPERINEAL RESECTION; RECTUM CANCER;

ADENOCARCINOMA; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COMBINED MODALITY THERAPY; FEMALE; HUMANS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PREOPERATIVE CARE; PROGNOSIS; RECTAL NEOPLASMS; SURVIVAL RATE;

EID: 79958119424     PISSN: 00224790     EISSN: 10969098     Source Type: Journal    
DOI: 10.1002/jso.21913     Document Type: Article

References (29)

1. Kapiteijn E, Marijnen CA, Nagtegaal ID, et al.: Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 2001;345:638-646.
2. Sauer R, Becker H, Hohenberger W, et al.: Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 2004;351:1731-1740.
3. Capirci C, Valentini V, Cionini L, et al.: Prognostic value of pathologic complete response after neoadjuvant therapy in locally advanced rectal cancer: Long-term analysis of 566 ypCR patients. Int J Radiat Oncol Biol Phys 2008;72:99-107.
4. Chang GJ, Rodriguez-Bigas MA, Eng C, et al.: Lymph node status after neoadjuvant radiotherapy for rectal cancer is a biologic predictor of outcome. Cancer 2009;115:5432-5440.
5. Kim NK, Baik SH, Seong JS, et al.: Oncologic outcomes after neoadjuvant chemoradiation followed by curative resection with tumor-specific mesorectal excision for fixed locally advanced rectal cancer: Impact of postirradiated pathologic downstaging on local recurrence and survival. Ann Surg 2006;244:1024-1030. (Pubitemid 44808646)
6. Rullier A, Laurent C, Capdepont M, et al.: Lymph nodes after preoperative chemoradiotherapy for rectal carcinoma: Number, status, and impact on survival. Am J Surg Pathol 2008;32:45-50.
7. Wichmann MW, Muller C, Meyer G, et al.: Effect of preoperative radiochemotherapy on lymph node retrieval after resection of rectal cancer. Arch Surg 2002;137:206-210. (Pubitemid 34142139)
8. Taflampas P, Christodoulakis M, Gourtsoyianni S, et al.: The effect of preoperative chemoradiotherapy on lymph node harvest after total mesorectal excision for rectal cancer. Dis Colon Rectum 2009;52:1470-1474.
9. Sobin LH, Gospodarowicz MK, Wittekind C: TNM Classification of Malignant Tumours (UICC International Union Against Cancer). 7th edition. New York: Wiley-Blackwell; 2009.
10. Goldstein NS, Sanford W, Coffey M, et al.: Lymph node recovery from colorectal resection specimens removed for adenocarcinoma. Trends over time and a recommendation for a minimum number of lymph nodes to be recovered. Am J Clin Pathol 1996;106:209-216. (Pubitemid 26277211)
11. Kim YW, Kim NK, Min BS, et al.: The influence of the number of retrieved lymph nodes on staging and survival in patients with stage II and III rectal cancer undergoing tumor-specific mesorectal excision. Ann Surg 2009;249:965-972.
12. Peschaud F, Benoist S, Julie C, et al.: The ratio of metastatic to examined lymph nodes is a powerful independent prognostic factor in rectal cancer. Ann Surg 2008;248:1067-1073.
13. Rosenberg R, Friederichs J, Schuster T, et al.: Prognosis of patients with colorectal cancer is associated with lymph node ratio: A single-center analysis of 3,026 patients over a 25-year time period. Ann Surg 2008;248:968-978.
14. Moug SJ, Saldanha JD, McGregor JR, et al.: Positive lymph node retrieval ratio optimises patient staging in colorectal cancer. Br J Cancer 2009;100:1530-1533.
15. Quirke P, Durdey P, Dixon MF, et al.: Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision. Lancet 1986;2:996-999. (Pubitemid 16005611)
16. Mekenkamp LJ, van Krieken JH, Marijnen CA, et al.: Lymph node retrieval in rectal cancer is dependent on many factors - The role of the tumor, the patient, the surgeon, the radiotherapist, and the pathologist. Am J Surg Pathol 2009;33:1547-1553.
17. Chang GJ, Rodriguez-Bigas MA, Skibber JM, et al.: Lymph node evaluation and survival after curative resection of colon cancer: Systematic review. J Natl Cancer Inst 2007;99:433-441. (Pubitemid 47073566)
18. Namm J, Ng M, Roy-Chowdhury S, et al.: Quantitating the impact of stage migration on staging accuracy in colorectal cancer. J Am Coll Surg 2008;207:882-887.
19. Tepper JE, O'Connell MJ, Niedzwiecki D, et al.: Impact of number of nodes retrieved on outcome in patients with rectal cancer. J Clin Oncol 2001;19:157-163. (Pubitemid 32063492)
20. Berger AC, Sigurdson ER, LeVoyer T, et al.: Colon cancer survival is associated with decreasing ratio of metastatic to examined lymph nodes. J Clin Oncol 2005;23:8706-8712. (Pubitemid 46211514)
21. Kim YS, Kim JH, Yoon SM, et al.: Lymph node ratio as a prognostic factor in patients with stage III rectal cancer treated with total mesorectal excision followed by chemoradiotherapy. Int J Radiat Oncol Biol Phys 2009;74:796-802.
22. Dekker JW, Peeters KC, Putter H, et al.: Metastatic lymph node ratio in stage III rectal cancer; prognostic significance in addition to the7th edition of the TNM classification. Eur J Surg Oncol 2010;36:1180-1186.
23. Leibold T, Shia J, Ruo L, et al.: Prognostic implications of the distribution of lymph node metastases in rectal cancer after neoadjuvant chemoradiotherapy. J Clin Oncol 2008;26:2106-2111.
24. Huh JW, Kim YJ, Kim HR: Ratio of metastatic to resected lymph nodes as a prognostic factor in node-positive colorectal cancer. Ann Surg Oncol 2010;17:2640-2646.
25. Ceelen W, Van Nieuwenhove Y, Pattyn P: Prognostic value of the lymph node ratio in stage III colorectal cancer: A systematic review. Ann Surg Oncol 2010;17:2847-2855.
26. Collette L, Bosset JF, den Dulk M, et al.: Patients with curative resection of cT3-4 rectal cancer after preoperative radiotherapy or radiochemotherapy: Does anybody benefit from adjuvant fluorouracil- based chemotherapy? A trial of the European Organisation for Research and Treatment of Cancer Radiation Oncology Group. J Clin Oncol 2007;25:4379-4386. (Pubitemid 350013843)
27. Huh JW, Kim HR: Postoperative chemotherapy after neoadjuvant chemoradiation and surgery for rectal cancer: Is it essential for patients with ypT0-2N0? J Surg Oncol 2009;100: 387-391.
28. Fietkau R, Barten M, Klautke G, et al.: Postoperative chemotherapy may not be necessary for patients with ypN0-category after neoadjuvant chemoradiotherapy of rectal cancer. Dis Colon Rectum 2006;49:1284-1292. (Pubitemid 44401376)
29. Bujko K, Glynne-Jones R, Bujko M: Does adjuvant fluoropyrimidine-based chemotherapy provide a benefit for patients with resected rectal cancer who have already received neoadjuvant radiochemotherapy? A systematic review of randomised trials. Ann Oncol 2010;21:1743-1750.