Lymph node ratio: Role in the staging of node-positive colon cancer

Annals of Surgical Oncology

Volumn 15, Issue 6, 2008, Pages 1600-1608

  Wang, Jiping ^a,b   Hassett, James M ^a   Dayton, Merril T ^a   Kulaylat, Mahmoud N ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Colon cancer; Lymph node; Lymph node ratio; Prognosis; Stage

Indexed keywords

AGE DISTRIBUTION; AGED; ARTICLE; CANCER GRADING; CANCER REGISTRY; CANCER STAGING; CANCER SURVIVAL; COLON CANCER; CONFIDENCE INTERVAL; CONTROLLED STUDY; FEMALE; HUMAN; KAPLAN MEIER METHOD; LYMPH NODE; MAJOR CLINICAL STUDY; MALE; PROGNOSIS; RACE DIFFERENCE; RISK FACTOR; SURVIVAL TIME; TUMOR VOLUME;

AGED; AGED, 80 AND OVER; ALGORITHMS; COLONIC NEOPLASMS; FEMALE; HUMANS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; RETROSPECTIVE STUDIES; SEER PROGRAM; SURVIVAL ANALYSIS; UNITED STATES;

EID: 43449102468     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-007-9716-x     Document Type: Article

References (32)

1. National Comprehensive Cancer Network Website: http://www.nccn.org/ patients/patient_gls/_english/_colon/1_introduction.asp
2. Hutter RVP. At last: worldwide agreement on the staging of cancer. Arch Surg 1987; 122:1235-9
3. AJCC Cancer Staging Manual, 6th ed. New York: Springer, 2002
4. Greene FL, Stewart AK, Norton J. A new TNM staging strategy for node-positive (stage III) colon cancer: An analysis of 50,042 patients. Ann Surg 2002; 236:416-21
5. Berger AC, Sigurdson ER, LeVoyer T, et al. Colon cancer survival is associated with decreasing ratio of metastatic to examined lymph nodes. J Clin Oncol 2005; 23:8706-12
6. Yu W, Choi GS, Wang I, et al. Comparison of five systems for staging lymph node metastasis in gastric cancer. Br J Surg 1997; 84:1305-9
7. Kodera Y, Yamamura Y, Shimizu Y, et al. Lymph node status assessment for gastric carcinoma: is the number of metastatic lymph nodes really practical as a parameter for N categories in the TNM classification? J Surg Oncol 1998; 69:15-20
8. Siewert JR, Bottcher FK, Stein HJ, et al. Relevant prognostic factors in gastric cancer: ten-year results of the German Gastric Cancer Study. Ann Surg 1998; 228:449-61
9. Inoue K, Nakane Y, Liyama H, et al. The superiority of ratio-based lymph node staging in gastric carcinoma. Ann Surg Oncol 2002; 9:27-34
10. van der Wal BC, Butzelaar RM, van der Meij S, et al. Axillary lymph node ratio and total number of removed lymph nodes: Predictors of survival in stage I and II breast cancer. Eur J Surg Oncol 2002; 28:481-9
11. Megale Costa LJ, Soares HP, Gaspar HA, et al. Ratio between positive lymph nodes and total dissected axillaries lymph nodes as an independent prognostic factor for disease-free survival in patients with breast cancer. Am J Clin Oncol 2004; 27:304-6
12. Vinh-Hung V, Verschraegen C, Promish DI, et al. Ratios of involved nodes in early breast cancer. Breast Cancer Res 2004; 6:R680-8
13. Voordeckers M, Vinh-Hung V, Van de Steene J, et al. The lymph node ratio as prognostic factor in node-positive breast cancer. Radiother Oncol 2004; 70:225-30
14. Truong PT, Berthelet E, Lee J, et al. Prognostic significance of the percentage of positive/dissected axillary nodes in breast cancer relapse and survival in patients with 1-3 positive axillary nodes. Cancer 2005; 103:2006-14
15. Woodward WA, Vinh-Hung V, Ueno NT, et al. Prognostic value of nodal ratios in node-positive breast cancer. J Clin Oncol 2006; 24:2910-6
16. De Ridder M, Vinh-Hung V, Van Nieuwenhove Y, et al. Prognostic value of the lymph node ratio in node positive colon cancer. Gut 2006; 55:1681
17. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958; 53:457-81
18. Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 1982; 143:29-36
19. Cox DR. Regression models and life tables. J R Stat Soc B 1972; 34:187-220
20. Chang GJ, Rodriguez-Bigas MA, Skibber JM, et al. Lymph node evaluation and survival after curative resection of colon cancer: systematic review. J Natl Cancer Inst 2007; 99:433-41
21. Marchet A, Mocellin S, Ambrosi A, et al. The ratio between metastasis and examined lymph nodes (N ratio) is an independent prognostic factor in gastric cancer regardless of the type of lymphadenectomy: results from an Italian multicentric study in 1853 patients. Ann Surg 2007; 245:543-52
22. Walker MJ, Osborne MD, Young DC, et al: The natural history of breast cancer with more than 10 positive nodes. Am J Surg 1995; 169:575-9
23. Gurkaynay M, Yildiz F, Atahan L. T3N0M0 breast cancer patients: A subgroup with favorable prognosis. Turkish J. Cancer 2003; 33:144-9
24. Wong JH, Severino R, Honnerbier MB, et al. Number of nodes examined and staging accuracy in colorectal carcinoma. J Clin Oncol 1999; 17:2896-900
25. Wong JH, Johnson DS, Hemmings D, et al. Assessing the quality of colorectal cancer staging: documenting the process in improving the staging of node negative cororectal cancer. Arch Surg 2005; 140:881-6
26. Swanson RS, Compton CC, Stewart AK, Bland KI. The prognosis of T3N0 colon cancer is dependent on the number of lymph nodes examined. Ann Surg Oncol 2003; 10:65-71
27. Tepper JE, O'Connell MJ, Niedzwiecki D, et al. Impact of number of nodes retrieved on outcome in patients with rectal cancer. J Clin Oncol 2001;19:157-63
28. Compton C, Fenoglio-Preiser CM, Pettigrew N, et al. American Joint Committee on Cancer Prognostic Factors Consensus Conference: Colorectal Working Group. Cancer 2000; 88:1739-57
29. Yarbro JW, Page DL, Fielding LP, et al. American Joint Committee on Cancer prognostic factors consensus conference. Cancer 1999; 86:2436-46
30. Goldstein NS, Weldon S, Coffey M, et al. Lymph node recovery from colorectal resection specimens removed from adenocarcinoma: Trends over time and a recommendation for a minimum number of lymph nodes to be recovered. Am J Clin Pathol 1996; 106:209-16
31. Kim J, Huynh R, Abraham I, et al. Number of lymph nodes examined and its impact on colorectal cancer staging. Am Surg 2006; 72:902-5
32. Berberoglu U. Prognostic significance of total lymph node number in patients with T1-4N0M0 colorectal cancer. Hepatogastroenterology 2004; 51:1689-93