Metastatic lymph node ratio as an independent prognostic variable in colorectal cancer: Study of 113 patients

Techniques in Coloproctology

Volumn 13, Issue 2, 2009, Pages 113-121

  Priolli, D G ^a   Cardinalli, I Aparecida ^a   Pereira, J Aires ^a   Alfredo, C Helaehil ^a   Margarido, N Fontana ^b   Martinez, C A Real ^a,c  

^a UNIVERSIDADE SÃO FRANCISCO   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c NONE   (Brazil)

Author keywords

Colorectal neoplasms; Lymph node excision; Lymph nodes; Prognosis; Survival analysis; Survival rate

Indexed keywords

ADENOCARCINOMA; ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER STAGING; CANCER SURVIVAL; COLORECTAL CARCINOMA; CONTROLLED STUDY; FEMALE; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PROGNOSIS; RETROSPECTIVE STUDY; SURVIVAL RATE;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; COHORT STUDIES; COLORECTAL NEOPLASMS; FEMALE; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; RETROSPECTIVE STUDIES; SURVIVAL RATE;

EID: 67650716410     PISSN: 11236337     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10151-009-0467-5     Document Type: Article

References (49)

1. Surveillance EpidemiologyEnd Results 2009 SEER Stat Fact Sheets. Cancer: Colon and Rectum National Cancer Institute Rockville, MD Surveillance Epidemiology and End Results (2009) SEER Stat Fact Sheets. Cancer: Colon and Rectum. National Cancer Institute, Rockville, MD http://seer.cancer.gov/ statfacts/html/colorect.html. Accessed 19 Apr 2009
2. P.M. Sanfelippo O.H. Beahrs 1972 Factors in the prognosis of adenocarcinoma of the colon and rectum Arch Surg 104 401 406
3. A.S. Cain L.A. Longino 1970 Carcinoma of the colon in children J Pediatr Surg 5 527 532
4. N. Wolmark H.S. Wieand H.E. Rockette 1983 The prognostic significance of tumor location and bowel obstruction in Dukes B and C colorectal cancer. Findings from the NSABP clinical trials Ann Surg 198 743 752 (Pubitemid 14202751)
5. R.S. Grinnel 1939 The grading and prognosis of carcinoma of the colon and rectum Ann Surg 109 500 533
6. C.E. Dukes 1932 The classification of cancer of the rectum J Pathol 35 323 332
7. V.B. Astler F.A. Coller 1954 The prognostic significance of direct extension of carcinoma of the colon and rectum Ann Surg 139 846 851
8. C.E. Dukes H.J.R. Bussey 1958 The spread of rectal cancer and its effect on prognosis Br J Cancer 12 309 320
9. T.B. Halvorsen E. Seim 1988 Influence of mucinous components on survival in colorectal adenocarcinomas: a multivariate analysis J Clin Pathol 41 1068 1072 (Pubitemid 18241590)
10. C.A.R. Martinez D.G. Priolli I.A. Cardinalli 2006 Correlação entre o padrão de distribuição tecidual e os valores séricos do antígeno carcinoembrionário em doentes com câncer Rev Bras Coloproct 26 41 53
11. Cutait R (1991) Contribuição ao estudo do antígeno carcinoembrionário e dos antígenos de superfície ABH no câncer colo-retal. Tese (Livre Docência) - Faculdade de Medicina da Universidade de São Paulo, São Paulo, pp 96
12. N. Khankhanian G.M. Mavligit W.O. Russell 1977 Prognostic significance of vascular invasion in colorectal cancer of Dukes' B class Cancer 39 1195 1200 (Pubitemid 8081194)
13. J.V. Cruz R. Cutait C.A.R. Martinez 2006 Importância prognostica da invasão neural no câncer colorretal. Estudo imunoistoquímico com a proteína S-10100 Rev Bras Coloproct 26 280 293
14. Y. Wang T. Jatkoe Y. Zhang 2004 Gene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer J Clin Oncol 22 1564 1571 (Pubitemid 41079793)
15. E.R. Sigurdson 2003 Lymph node dissection: is it diagnostic or therapeutic? J Clin Oncol 21 965 967 (Pubitemid 46594122)
16. A. Gajra N. Newman G.P. Gamble 2003 Effect of number of lymph nodes sampled on outcome in patients with stage I non-small-cell lung cancer J Clin Oncol 21 1029 1034 (Pubitemid 46594131)
17. J.H. Wong R. Severino M.B. Honnebier 1999 Number of nodes examined and staging accuracy in colorectal carcinoma J Clin Oncol 17 2896 2900 (Pubitemid 29415250)
18. T.E. Le Voyer E.R. Sigurdson A.L. Hanlon 2003 Colon cancer survival is associated with increasing number of lymph nodes analysed: a secondary survey of intergroup trial INT-0089 J Clin Oncol 21 2912 2919 (Pubitemid 46621841)
19. O. Celen E. Yildirim U. Berberoglu 2007 Prognostic impact of positive lymph node ratio in gastric carcinoma J Surg Oncol 96 95 101 (Pubitemid 47264811)
20. R. Persiani S. Rausei A. Biondi 2008 Ratio of metastatic lymph nodes: impact on staging and survival of gastric cancer Eur J Surg Oncol 34 519 524
21. H.W. Herr B.H. Bochner G. Dalbagni 2002 Impact of the number of lymph nodes retrieved on outcome in patients with muscle invasive bladder cancer J Urol 167 1295 1298 (Pubitemid 34132073)
22. L. Weir C. Speers Y. D'yachkova 2002 Prognostic significance of the number of axillary lymph nodes removed in patients with node negative breast cancer J Clin Oncol 20 1793 1799 (Pubitemid 34273268)
23. A.C. Berger J.C. Watson E.A. Ross 2004 The metastatic/examined lymph node ratio is an important prognostic factor after pancreaticoduodenectomy for pancreatic adenocarcinoma Am Surg 70 235 240
24. H.Y. Lee H.J. Choi K.J. Park 2007 Prognostic significance of metastatic lymph node ratio in node-positive colon carcinoma Ann Surg Oncol 14 1712 1717
25. A.C. Berger E.R. Sigurdson T. LeVoyer 2005 Colon cancer survival is associated with decreasing ratio of metastatic to examined lymph nodes J Clin Oncol 23 8706 8712 (Pubitemid 46211514)
26. J. Wang J.M. Hassett M.T. Dayton 2008 Lymph node ratio: role in the staging of node-positive colon cancer Ann Surg Oncol 15 1600 1608
27. K. Derwinger G. Carlsson B. Gustavsson 2008 A study of lymph node ratio as a prognostic marker in colon cancer Eur J Surg Oncol 34 771 775
28. D.C. Trufelli C. Miranda Vda C.C. Palos 2007 Positive/total dissected lymph nodes ratio as a prognostic factor in colorectal cancer Rev Assoc Med Bras 53 539 542
29. P. Schumacher S. Dineen C. Barnett Jr 2007 The metastatic lymph node ratio predicts survival in colorectal cancer Am J Surg 194 827 831
30. H. Nelson N. Petrelli A. Carlin National Cancer Institute Expert Panel 2001 Guideline 2000 for colon and rectal cancer surgery J Natl Cancer Inst 93 583 596 (Pubitemid 32409626)
31. E. Bando Y. Yonemura K. Taniguchi 2002 Outcome of ratio of lymph node metastasis in gastric carcinoma Ann Surg Oncol 9 775 784
32. American Joint Committee on Cancer 2007 Collaborative staging and coding manual American Joint Committee on Cancer Chicago, IL American Joint Committee on Cancer (2007) Collaborative staging and coding manual. American Joint Committee on Cancer, Chicago, IL http://cancerstaging.org/cstage/manuals.html. Accessed 19 Apr 2009
33. N.S. Goldstein W. Sanford M. Coffey 1996 Lymph node recovery from colorectal resection specimens removed for adenocarcinoma: trends over time and a recommendation for a minimum number of lymph nodes to be recovered Am J Clin Pathol 106 209 216 (Pubitemid 26277211)
34. S.L. Chen A.J. Bilchik 2006 More extensive nodal dissection improves survival for stages I to III of colon cancer: a population-based study Ann Surg 244 602 610
35. S.P. Mönig S.E. Baldus T.K. Zirbes 1999 Lymph node size and metastatic infiltration in colon cancer Ann Surg Oncol 6 579 581 (Pubitemid 29428798)
36. T.F. Wood S. Saha D.L. Morton 2001 Validation of lymphatic mapping in colorectal cancer: in vivo, ex vivo, and laparoscopic techniques Ann Surg Oncol 8 150 157 (Pubitemid 32199412)
37. P. Hermanek J. Giedl O. Dworak 1989 Two programs for examination of regional lymph nodes in colorectal carcinoma with regard to the new pN classification Pathol Res Pract 185 867 873 (Pubitemid 20070799)
38. S.L. Wong H. Ji B.K. Hollenbeck 2007 Hospital lymph node examination rates and survival after resection for colon cancer JAMA 298 2149 2154 (Pubitemid 350106653)
39. D. Schrag K.S. Panageas E. Riedel 2003 Surgeon volume compared to hospital volume as a predictor of outcome following primary colon cancer resection J Surg Oncol 83 68 78 (Pubitemid 36667413)
40. J.A. Meyerhardt P.J. Catalano D. Schrag 2003 Association of hospital procedure volume and outcomes in patients with colon cancer at high risk for recurrence Ann Intern Med 139 649 657
41. L. Herrera-Ornelas J. Justiniano N. Castillo 1987 Metastases in small nodes from colon cancer Arch Surg 122 1253 1256 (Pubitemid 18021277)
42. N.Y. Haboubi P. Clark S.M. Kaftan 1992 The importance of combining xylene clearance and immunohistochemistry in the accurate staging of colorectal carcinoma J R Soc Med 85 386 388
43. R.T. Palma J. Waisberg S. Bromberg 2003 Micrometastasis in regional lymph nodes of extirpated colorectal carcinoma: immunohistochemical study using anti-cytokeratin antibodies AE1/AE3 Colorectal Dis 5 164 168 (Pubitemid 36442840)
44. L. Messerini F. Cianchi C. Cortesini 2006 Incidence and prognostic significance of occult tumor cells in lymph nodes from patients with stage IIA colorectal carcinoma Hum Pathol 37 1259 1267 (Pubitemid 44380278)
45. A.R. Feinstein D.M. Sosin C.K. Wells 1985 The Will Rogers phenomenon: stage migration and new diagnostic techniques as a source of misleading statistics for survival in cancer N Engl J Med 312 1604 1608 (Pubitemid 15062653)
46. K. Inoue Y. Nakane H. Iiyama 2002 The superiority of ratio-based lymph node staging in gastric carcinoma Ann Surg Oncol 9 27 34 (Pubitemid 34262894)
47. J.M. Mammen L.E. James M. Molloy 2007 The relationship of lymph node dissection and colon cancer survival in the Veterans Affairs Central Cancer Registry Am J Surg 194 349 354 (Pubitemid 47212037)
48. Y.B. Ding G.Y. Chen J.G. Xia 2004 Correlation of tumor-positive ratio and number of perigastric lymph nodes with prognosis of patients with surgically-removed gastric carcinoma World J Gastroenterol 10 182 185
49. L. Bui E. Rempel D. Reeson 2006 Lymph node counts, rates of positive lymph nodes, and patient survival for colon cancer surgery in Ontario, Canada: a population-based study J Surg Oncol 93 439 445 (Pubitemid 44651266)