The lymph node ratio is a powerful prognostic factor of node-positive colon cancers undergoing potentially curative surgery

World Journal of Surgery

Volumn 33, Issue 12, 2009, Pages 2704-2713

  Galizia, Gennaro ^a   Orditura, Michele ^a   Ferraraccio, Francesca ^a   Castellano, Paolo ^a   Pinto, Margherita ^a   Zamboli, Anna ^a   Cecere, Sabrina ^a   De Vita, Ferdinando ^a   Pignatelli, Carlo ^a   Lieto, Eva ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT;

ADJUVANT CHEMOTHERAPY; ADULT; AGED; ARTICLE; CANCER STAGING; COLON TUMOR; FEMALE; HUMAN; LYMPH NODE; MALE; MIDDLE AGED; PATHOLOGY; PROGNOSIS; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; CHEMOTHERAPY, ADJUVANT; COLONIC NEOPLASMS; FEMALE; HUMANS; LYMPH NODES; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; TREATMENT OUTCOME;

EID: 77956093067     PISSN: 03642313     EISSN: 14322323     Source Type: Journal    
DOI: 10.1007/s00268-009-0207-z     Document Type: Article

References (33)

1. Jemal A, Siegel R, Ward E et al (2008) Cancer statistics, 2008. CA Cancer J Clin 58:71-96
2. Rosenberg R, Friederichs J, Schuster T et al (2008) Prognosis of patients with colorectal cancer is associated with lymph node ratio: a single-center analysis of 3,026 patients over a 25-year time period. Ann Surg 248:968-978
3. Le Voyer TE, Sigurdson ER, Hanlon AL et al (2003) Colon cancer survival is associated with increasing number of lymph nodes analyzed: a secondary survey of intergroup trial INT-0089. J Clin Oncol 21:2912-2919
4. Derwinger K, Carlsson G, Gustavsson B (2008) A study of lymph node ratio as a prognostic marker in colon cancer. Eur J Surg Oncol 34:771-775
5. AJCC Cancer staging manual (2002) 6th edn. Springer-Verlag, New York, pp 113-123
6. Van Cutsem EJD, Oliveira J (2008) Colon cancer: ESMO clinical recommendations for diagnosis, adjuvant treatment and followup. Ann Oncol 19(Suppl 2):ii29-ii30
7. Baxter NN, Virnig DJ, Rothenberger DA et al (2005) Lymph node evaluation in colorectal cancer patients: a population-based study. J Natl Cancer Inst 97:219-225
8. Vather R, Sammour T, Kahokehr A et al (2009) Lymph node evaluation and long-term survival in stage II and stage III colon cancer: a national study. Ann Surg Oncol 16:585-593
9. Johnson PM, Porter GA, Ricciardi R et al (2006) Increasing negative lymph node count is independently associated with improved long-term survival in stage IIIB and IIIC colon cancer. J Clin Oncol 24:3570-3575
10. Chang GJ, Rodriguez-Bigas MA, Skibber JM et al (2007) Lymph node evaluation and survival after curative resection of colon cancer: systematic review. J Natl Cancer Inst 99:433-441
11. Telian SH, Bilchik AJ (2008) Significance of the lymph node ratio in stage III colon cancer. Ann Surg Oncol 15:1557-1558
12. Sargent D, Sobrero A, Grothey A et al (2009) Evidence for cure by adjuvant therapy in colon cancer: observations based on individual patient data from 20,898 patients on 18 randomized trials. J Clin Oncol 27:872-877
13. Wong SL, Ji H, Hollenbeck BK, Morris AM et al (2007) Hospital lymph node examination rates and survival after resection for colon cancer. JAMA 298:2149-2154
14. Evans MD, Barton K, Rees A et al (2008) The impact of surgeon and pathologist on lymph node retrieval in colorectal cancer and its impact on survival for patients with Dukes' stage B disease. Colorectal Dis 10:157-164
15. Kelder W, Inberg B, Plukker JT et al (2008) Effect of modified Davidson's fixative on examined number of lymph nodes and TNM-stage in colon carcinoma. Eur J Surg Oncol 34:525-530
16. Wang J, Hassett JM, Dayton MT et al (2008) Lymph node ratio: role in the staging of node-positive colon cancer. Ann Surg Oncol 15:1600-1608
17. Truong PT, Vinh-Hung V, Cserni G et al (2008) The number of positive nodes and the ratio of positive to excised nodes are significant predictors of survival in women with micrometastatic node-positive breast cancer. Eur J Cancer 44:1670-1677
18. Slidell MB, Chang DC, Cameron JL et al (2008) Impact of total lymph node count and lymph node ratio on staging and survival after pancreatectomy for pancreatic adenocarcinoma: a large, population-based analysis. Ann Surg Oncol 15:165-174
19. Mariette C, Piessen G, Briez N et al (2008) The number of metastatic lymph nodes and the ratio between metastatic and examined lymph nodes are independent prognostic factors in oesophageal cancer regardless of neoadjuvant chemoradiation or lymphadenectomy extent. Ann Surg 247:365-371
20. Marchet A, Mocellin S, Ambrosi A et al (2008) The prognostic value of N-ratio in patients with gastric cancer. Validation in a large, multicenter series. Eur J Surg Oncol 34:159-165
21. Berger AC, Sigurdson ER, LeVoyer T et al (2005) Colon cancer survival is associated with decreasing ratio of metastatic to examined lymph nodes. J Clin Oncol 23:8706-8712
22. De Ridder M, Vinh-Hung V, Van Nieuwenhove Y et al (2006) Prognostic value of the lymph node ratio in node positive colon cancer. Gut 55:1681
23. Lee HY, Choi HJ, Park KJ et al (2007) Prognostic significance of metastatic lymph node ratio in node-positive colon carcinoma. Ann Surg Oncol 14:1712-1717
24. Schumacher P, Dineen S, Barnett C et al (2007) The metastatic lymph node ratio predicts survival in colon cancer. Am J Surg 194:827-832
25. Peschaud F, Benoist S, Julié C et al (2008) The ratio of metastatic to examined lymph nodes is a powerful independent prognostic factor in rectal cancer. Ann Surg 248:1067-1073
26. Chapuis PH, Dent OF, Bokey EL et al (2004) Adverse histopathological findings as a guide to patient management after curative resection of node positive colon cancer. Br J Surg 91:349-354
27. Newell KJ, Sawka BW, Rudrick BF et al (2001) GEWF solution. An inexpensive, simple, and effective aid for the retrieval of lymph nodes from colorectal cancer resections. Arch Pathol Lab Med 125:642-645
28. Bembenek A, Schneider U, Gretschel S et al (2005) Detection of lymph node micrometastases and isolated tumor cells in sentinel and nonsentinel nodes of colon cancer patients. World J Surg 29:1172-1175
29. de Haas RJ, Wicherts DA, Hobbelink MG et al (2007) Sentinel lymph node mapping in colon cancer: current status. Ann Surg Oncol 14:1070-1080
30. Galizia G, Lieto E, Ferraraccio F et al (2004) Determination of molecular marker expression can predict clinical outcome in colon carcinomas. Clin Cancer Res 10:3490-3499
31. Chan YH (2004) Biostatistics 203. Survival analysis. Singapore Med J 45:249-256
32. Compton CC, Fielding LP, Burgart LJ et al (2000) Prognostic factors in colorectal cancer: College of American Pathologists Consensus Statement 1999. Arch Pathol Lab Med 124:979-994
33. Greene FL, Stewart AK, Norton J (2002) A new TNM staging strategy for node-positive (stage III) colon cancer: an analysis of 50,042 patients. Ann Surg 236:416-421