Design and synthesis of 1,2,3-triazole-fused chiral medium-ring benzo-heterocycles, scaffolds mimicking benzolactams

Journal of Organic Chemistry

Volumn 77, Issue 12, 2012, Pages 5399-5405

  Das Adhikary, Nirmal ^a   Chattopadhyay, Partha ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CHIRAL MEDIUM; HETEROCYCLES; INTERMOLECULAR CYCLOADDITION; MACROCYCLIC PRODUCTS;

AMIDES; SCAFFOLDS; SUGARS;

NITROGEN COMPOUNDS;

1,2,3 TRIAZOLE DERIVATIVE; 10,12,12 TRIMETHYL 10,10A,13A,14A TETRAHYDRO[1,3]DIOXOLO[4',5':4,5]FURO[2,3 C]BENZO[G][1,2,3]TRIAZOLO[1,5 A][1,5]DIAZOCIN 9(10BH) ONE; 10,12,12 TRIMETHYL 9,10,10A,10B,13A,14A HEXAHYDRO[1,3]DIOXOLO[4',5':4,5]FURO[2,3 C]BENZO[G][1,2,3]TRIAZOLO[1,5 A][1,5]DIAZOCINE; 12,12 DIMETHYL 10A,10B,13A,14A TETRAHYDRO 9H [1,3]DIOXOLO[4',5':4,5]FURO[3,2 B]BENZO[F ][1,2,3]TRIAZOLO[5,1 D][1,5]OXAZOCINE; 2,3 (ISOPROPYLIDENEDIOXY)[1,5:9,10] 1,2,3 TRIAZOLO 2,3,3A,10A TETRAHYDROFURO[3,2 C][1,5]BENZOXAZEPINE; 3 ACETOXY 4 (ACETOXYMETHYL)[1,5:1,2][1,2,3 TRIAZOLO] 3,4,6 TRIHYDROBENZO[C][1,5]OXAZOCINE; 3 DEOXY 3 (N 4 NITROBENZENESULFONYL N METHYLAMINO) 1,2:5,6 DI O ISOPROPYLIDENE ALPHA DEXTRO GLUCOFURANOSE; 3 DEOXY 3 (N 4 NITROBENZENESULFONYLAMINO) 1,2:5,6 DI O ISOPROPYLIDENE ALPHA DEXTRO GLUCOFURANOSE; 5 ETHYNYL 6 (N 4 NITROBENZENESULFONYL N METHYLAMINO) 2,2 DIMETHYLTETRAHYDROFURO[2,3 D][1,3]DIOXOLE; 5 ETHYNYL 6 METHYLAMINO 2,2 DIMETHYLTETRAHYDROFURO[2,3 D][1,3]DIOXOLE; 5 METHOXY 7,7 DIMETHYL 3B,5,5A,8A,8B,10 HEXAHYDRO[1,3]DIOXOLO[4',5':4,5]PYRANO[3,2 B]BENZO[F ][1,2,3]TRIAZOLO[5,1 D][1,5]OXAZOCINE; 6 (2 AZIDOBENZOYL)METHYLAMINO 5 ETHYNYL 2,2 DIMETHYLTETRAHYDROFURO[2,3 D][1,3]DIOXOLE; 6 (2 AZIDOBENZYLOXY) 5 (2,2 DIMETHYL[1,3]DIOXOLAN 4 YL) 2,2 DIMETHYLTETRAHYDROFURO[2,3 D][1,3]DIOXOLE; 6 (2 AZIDOBENZYLOXY) 5 ETHYNYL 2,2 DIMETHYLTETRAHYDROFURO[2,3 D][1,3]DIOXOLE; 6 (2 AZIDOPHENOXY) 5 ETHYNYL 2,2 DIMETHYLTETRAHYDROFURO[2,3 D][1,3]DIOXOLE; 6 [(2 AZIDOPHENOXY) 5 (2,2 DIMETHYL[1,3]DIOXOLAN 4 YL)] 2,2 DIMETHYLTETRAHYDROFURO[2,3 D][1,3]DIOXOLE; 6 [N (2 AZIDOBENZYL) N METHYLAMINO] 5 ETHYNYL 2,2 DIMETHYLTETRAHYDROFURO[2,3 D][1,3]DIOXOLE; 6,6,19,19 TETRAMETHYL 3B,4A,7A,7B,16B,17A,20A,20B OCTAHYDRO[1,3]DIOXOLO[4',5':4,5]FURO[2,3 F ][1,3]DIOXOLO[4',5':4,5]FURO[2,3 M]DIBENZO[B,I]BIS( [1,2,3]TRIAZOLO)[1,5 D:1',5' K][1,8,4,11]DIOXADIAZACYCLOTETRADECINE; BENZO HETEROCYCLE DERIVATIVE; BENZOLACTAM DERIVATIVE; FUSED HETEROCYCLIC RINGS; LACTAM DERIVATIVE; METHYL 4 O (2 AZIDOBENZYL) 2,3 O ISOPROPYLIDENE ALPHA DEXTRO MANNOPYRANOSIDE; METHYL 4 O (2 AZIDOBENZYL) 5 ETHYNYL 2,3 O ISOPROPYLIDENE ALPHA DEXTRO MANNOPYRANOSIDE; METHYL 4 O (2 AZIDOBENZYL) 6 O (TERT BUTYLDIMETHYLSILYL) 2,3 O ISOPROPYLIDENE ALPHA DEXTRO MANNOPYRANOSIDE; UNCLASSIFIED DRUG;

ARTICLE; BIOEQUIVALENCE; CHEMICAL STRUCTURE; CHIRALITY; CYCLOADDITION; DRUG DESIGN; DRUG SYNTHESIS;

CYCLIZATION; HETEROCYCLIC COMPOUNDS; LACTAMS, MACROCYCLIC; MOLECULAR STRUCTURE; STEREOISOMERISM; TRIAZOLES;

EID: 84862577505     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo3004327     Document Type: Article

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