Human β3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 18, 2000, Pages 2111-2114

  Brockunier, Linda L ^a   Parmee, Emma R ^a   Ok, Hyun O ^a   Candelore, Mari R ^a   Cascieri, Margaret A ^a   Colwell Jr , Lawrence F ^a   Deng, Liping ^a   Feeney, William P ^a   Forrest, Michael J ^a   Hom, Gary J ^a   MacIntyre, D Euan ^a   Tota, Laurie ^a   Wyvratt, Matthew J ^a   Fisher, Michael H ^a   Weber, Ann E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; BENZENESULFONAMIDE DERIVATIVE; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; TRIFLUOROMETHYLBENZYL DERIVATIVE; UNCLASSIFIED DRUG; BENZENESULFONAMIDE; CYCLIC AMP; ISOPRENALINE; SULFONAMIDE; TRIAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DOG; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; LIPOLYSIS; NONHUMAN; RHESUS MONKEY; ANIMAL; BIOAVAILABILITY; CHEMICALLY INDUCED DISORDER; CHO CELL; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; HAMSTER; HUMAN; INFUSION; MACACA; METABOLISM; ORAL DRUG ADMINISTRATION; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TACHYCARDIA;

ANIMALIA; CANIS FAMILIARIS; MACACA MULATTA;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHO CELLS; CRICETINAE; CYCLIC AMP; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INFUSIONS, PARENTERAL; ISOPROTERENOL; LIPOLYSIS; MACACA MULATTA; PROTEIN BINDING; RECEPTORS, ADRENERGIC, BETA-3; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TACHYCARDIA; TRIAZOLES;

EID: 0033623166     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00422-4     Document Type: Article

References (15)