Novel Chimeric Scaffolds to Extend the Exploration of Receptor Space: Hybrid β-D-Glucose-Benzoheterodiazepine Structures for Broad Screening. Effect of Amide Alkylation on the Course of Cyclization Reactions

Journal of Organic Chemistry

Volumn 69, Issue 2, 2004, Pages 280-302

  Abrous, Leïla ^a,b   Jokiel, Patrick A ^a,c   Friedrich, Sarah R ^a,d   Hynes Jr , John ^a,e   Smith III, Amos B ^a   Hirschmann, Ralph ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b PFIZER INC   (United States)

^c PHARMACOPEIA INC   (United States)

^d GLAXOSMITHKLINE   (United States)

^e BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; CONFORMATIONS; DIMERS; MOLECULAR DYNAMICS; NITROGEN COMPOUNDS; PROTEINS; SYNTHESIS (CHEMICAL);

BIOLOGICAL SCREENING;

GLUCOSE;

AMIDE; BENZOHETERODIAZEPINE DERIVATIVE; BETA GLUCOSE; DIAZEPINE DERIVATIVE; GLUCOSE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CHEMICAL STRUCTURE; CHIMERA; CYCLIZATION; DERIVATIZATION; SCREENING; STRUCTURE ANALYSIS;

ALKYLATION; AMIDES; BENZODIAZEPINES; ESTERIFICATION; GLUCOSE; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR STRUCTURE; SPECTROPHOTOMETRY, INFRARED;

EID: 0347763381     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0352068     Document Type: Article

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