메뉴 건너뛰기




Volumn 486, Issue 7403, 2012, Pages 335-340

Engineering H5N1 avian influenza viruses to study human adaptation

Author keywords

[No Author keywords available]

Indexed keywords

AVIAN INFLUENZA; DISEASE TRANSMISSION; GENETIC ENGINEERING; MUSTELID;

EID: 84862574706     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11170     Document Type: Review
Times cited : (52)

References (102)
  • 1
    • 84861394598 scopus 로고    scopus 로고
    • Experimental adaptation of an influenza H5 HA confers respiratory droplet transmissionto a reassortantH5HA/H1N1virus in ferrets
    • this issue
    • Imai, M. et al. Experimental adaptation of an influenza H5 HA confers respiratory droplet transmissionto a reassortantH5HA/H1N1virus in ferrets.Nature http://dx.doi.org/10.1038/nature10831 (this issue).
    • Nature
    • Imai, M.1
  • 2
    • 84862547354 scopus 로고    scopus 로고
    • Aerosol transmission of avian influenza A/H5N1 virus
    • 22 June
    • Herfst, S. et al. Aerosol transmission of avian influenza A/H5N1 virus. Science (22 June 2012).
    • (2012) Science
    • Herfst, S.1
  • 3
    • 84857125494 scopus 로고    scopus 로고
    • Dangerous for ferrets: Lethal for humans?
    • Doherty, P. C.&Thomas, P. G.Dangerous for ferrets: lethal for humans?BMCBiol. 10, 10 (2012).
    • (2012) BMC Biol. , vol.10 , Issue.10
    • Doherty, P.C.1    Thomas, P.G.2
  • 4
    • 84857659913 scopus 로고    scopus 로고
    • Preventing pandemics: The fight over flu
    • Fouchier, R. et al. Preventing pandemics: the fight over flu. Nature 481, 257-259 (2012).
    • (2012) Nature , vol.481 , pp. 257-259
    • Fouchier, R.1
  • 5
    • 84860531728 scopus 로고    scopus 로고
    • Mammalian-transmissible H5N1 influenza: Facts and perspective
    • Osterholm, M. T. & Kelley, N. S. Mammalian-transmissible H5N1 influenza: facts and perspective. MBio 3, 2 (2012).
    • (2012) MBio , vol.3 , Issue.2
    • Osterholm, M.T.1    Kelley, N.S.2
  • 6
    • 84855808717 scopus 로고    scopus 로고
    • Don't censor life-saving science
    • Palese, P. Don't censor life-saving science. Nature 481, 115 (2012).
    • (2012) Nature , vol.481 , pp. 115
    • Palese, P.1
  • 7
    • 84857860596 scopus 로고    scopus 로고
    • Mammalian-transmissible H5N1 influenza: The dilemma of dual-use research
    • Webster, R. G. Mammalian-transmissible H5N1 influenza: the dilemma of dual-use research. MBio 3, 1 (2012).
    • (2012) MBio , vol.3 , Issue.1
    • Webster, R.G.1
  • 8
    • 51949109019 scopus 로고    scopus 로고
    • Cross-species virus transmission and the emergence of new epidemic diseases
    • Parrish, C. R. et al. Cross-species virus transmission and the emergence of new epidemic diseases. Microbiol. Mol. Biol. Rev. 72, 457-470 (2008).
    • (2008) Microbiol. Mol. Biol. Rev. , vol.72 , pp. 457-470
    • Parrish, C.R.1
  • 10
    • 77956499048 scopus 로고    scopus 로고
    • Influenza virus evolution, host adaptation, and pandemic formation
    • Taubenberger, J. K. & Kash, J. C. Influenza virus evolution, host adaptation, and pandemic formation. Cell Host Microbe 7, 440-451 (2010).
    • (2010) Cell Host Microbe , vol.7 , pp. 440-451
    • Taubenberger, J.K.1    Kash, J.C.2
  • 12
    • 84863011522 scopus 로고    scopus 로고
    • Pause on avian flu transmission research
    • Fouchier, R. A. et al. Pause on avian flu transmission research. Science 335, 400-401 (2012).
    • (2012) Science , vol.335 , pp. 400-401
    • Fouchier, R.A.1
  • 13
    • 84856957523 scopus 로고    scopus 로고
    • H5N1: Flu transmission work is urgent
    • Kawaoka, Y. H5N1: Flu transmission work is urgent. Nature 482, 155 (2012).
    • (2012) Nature , vol.482 , pp. 155
    • Kawaoka, Y.1
  • 16
    • 33746521094 scopus 로고
    • Reactions of monkeys to experimental mixed influenza and Streptococcus infections: An analysis of the relative roles of humoral and cellular immunity, with the description of an intercurrent nephritic syndrome
    • Wilson, H. E., Saslaw, S., Doan, C. A., Woolpert, O. C. & Schwab, J. L. Reactions of monkeys to experimental mixed influenza and Streptococcus infections: an analysis of the relative roles of humoral and cellular immunity, with the description of an intercurrent nephritic syndrome. J. Exp. Med. 85, 199-215 (1947).
    • (1947) J. Exp. Med. , vol.85 , pp. 199-215
    • Wilson, H.E.1    Saslaw, S.2    Doan, C.A.3    Woolpert, O.C.4    Schwab, J.L.5
  • 17
    • 34247614133 scopus 로고    scopus 로고
    • Understanding the complex pathobiology of high pathogenicity avian influenza viruses in birds
    • Swayne, D. E. Understanding the complex pathobiology of high pathogenicity avian influenza viruses in birds. Avian Dis. 51, 242-249 (2007). (Pubitemid 46671286)
    • (2007) Avian Diseases , vol.51 , Issue.SUPPL. 1 , pp. 242-249
    • Swayne, D.E.1
  • 18
    • 84960989501 scopus 로고
    • Influenza: The new acquayantance
    • Francis, T. Jr. Influenza: the new acquayantance. Ann. Intern. Med. 39, 203-221 (1953).
    • (1953) Ann. Intern. Med. , vol.39 , pp. 203-221
    • Francis Jr., T.1
  • 19
    • 0015541607 scopus 로고
    • Recycling of Asian and Hong Kong influenza A virus hemagglutinins in man
    • Masurel, N. & Marine, W. M. Recycling of Asian and Hong Kong influenza A virus hemagglutinins in man. Am. J. Epidemiol. 97, 44-49 (1973).
    • (1973) Am. J. Epidemiol. , vol.97 , pp. 44-49
    • Masurel, N.1    Marine, W.M.2
  • 20
    • 0037135669 scopus 로고    scopus 로고
    • Realities and enigmas of human viral influenza: Pathogenesis, epidemiology and control
    • Hilleman, M. R. Realities and enigmas of human viral influenza: pathogenesis, epidemiology and control. Vaccine 20, 3068-3087 (2002).
    • (2002) Vaccine , vol.20 , pp. 3068-3087
    • Hilleman, M.R.1
  • 21
    • 67650892251 scopus 로고    scopus 로고
    • The persistent legacy of the 1918 influenza virus
    • Morens, D. M., Taubenberger, J. K.&Fauci, A. S. The persistent legacy of the 1918 influenza virus. N. Engl. J. Med. 361, 225-229 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 225-229
    • Morens, D.M.1    Taubenberger, J.K.2    Fauci, A.S.3
  • 22
    • 80054995402 scopus 로고    scopus 로고
    • Reversion of PB2-627E to-627K during replication of an H5N1 Clade 2.2 virus in mammalian hosts depends on the origin of the nucleoprotein
    • Bogs, J. et al. Reversion of PB2-627E to-627K during replication of an H5N1 Clade 2.2 virus in mammalian hosts depends on the origin of the nucleoprotein. J. Virol. 85, 10691-10698 (2011).
    • (2011) J. Virol. , vol.85 , pp. 10691-10698
    • Bogs, J.1
  • 24
    • 0035823083 scopus 로고    scopus 로고
    • Molecular basis for high virulence of Hong Kong H5N1 influenza a viruses
    • DOI 10.1126/science.1062882
    • Hatta, M., Gao, P., Halfmann, P. & Kawaoka, Y. Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science 293, 1840-1842 (2001). (Pubitemid 32845783)
    • (2001) Science , vol.293 , Issue.5536 , pp. 1840-1842
    • Hatta, H.1    Gao, P.2    Halfmann, P.3    Kawaoka, Y.4
  • 25
    • 33645981586 scopus 로고    scopus 로고
    • Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus
    • Stevens, J. et al. Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus. Science 312, 404-410 (2006).
    • (2006) Science , vol.312 , pp. 404-410
    • Stevens, J.1
  • 26
    • 34250829563 scopus 로고    scopus 로고
    • Inefficient transmission of H5N1 influenza viruses in a ferret contact model
    • Yen, H. L. et al. Inefficient transmission of H5N1 influenza viruses in a ferret contact model. J. Virol. 81, 6890-6898 (2007).
    • (2007) J. Virol. , vol.81 , pp. 6890-6898
    • Yen, H.L.1
  • 27
    • 70349998184 scopus 로고    scopus 로고
    • An early 'classical' swine H1N1 influenza virus shows similar pathogenicity to the 1918 pandemic virus in ferrets and mice
    • Memoli, M. J. et al. An early 'classical' swine H1N1 influenza virus shows similar pathogenicity to the 1918 pandemic virus in ferrets and mice. Virology 393, 338-345 (2009).
    • (2009) Virology , vol.393 , pp. 338-345
    • Memoli, M.J.1
  • 28
    • 0031688699 scopus 로고    scopus 로고
    • A mouse model for evaluation of prophylaxis and therapy of ebola hemorrhagic fever
    • Bray, M., Davis, K., Geisbert, T., Schmaljohn, C. & Huggins, J. A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever. J. Infect. Dis. 178, 651-661 (1998). (Pubitemid 28397211)
    • (1998) Journal of Infectious Diseases , vol.178 , Issue.3 , pp. 651-661
    • Bray, M.1    Davis, K.2    Geisbert, T.3    Schmaljohn, C.4    Huggins, J.5
  • 29
    • 0035666691 scopus 로고    scopus 로고
    • Haematological, biochemical and coagulation changes in mice, guinea-pigs and monkeys infected with a mouse-adapted variant of Ebola Zaire virus
    • DOI 10.1053/jcpa.2001.0503
    • Bray, M., Hatfill, S., Hensley, L. & Huggins, J. W. Haematological, biochemical and coagulation changes in mice, guinea-pigs and monkeys infected with a mouseadapted variant of Ebola Zaire virus. J. Comp. Pathol. 125, 243-253 (2001). (Pubitemid 34023737)
    • (2001) Journal of Comparative Pathology , vol.125 , Issue.4 , pp. 243-253
    • Bray, M.1    Hatfill, S.2    Hensley, L.3    Huggins, J.W.4
  • 30
    • 77954501872 scopus 로고    scopus 로고
    • Evaluation of replication and cross-reactive antibody responses of H2 subtype influenza viruses in mice and ferrets
    • Chen, G. L. et al. Evaluation of replication and cross-reactive antibody responses of H2 subtype influenza viruses in mice and ferrets. J. Virol. 84, 7695-7702 (2010).
    • (2010) J. Virol. , vol.84 , pp. 7695-7702
    • Chen, G.L.1
  • 32
    • 34648824633 scopus 로고    scopus 로고
    • Evaluation of replication and pathogenicity of avian influenza A H7 subtype viruses in a mouse model
    • DOI 10.1128/JVI.00970-07
    • Joseph, T. et al. Evaluation of replication and pathogenicity of avian influenza a H7 subtype viruses in a mouse model. J. Virol. 81, 10558-10566 (2007). (Pubitemid 47463329)
    • (2007) Journal of Virology , vol.81 , Issue.19 , pp. 10558-10566
    • Joseph, T.1    McAuliffe, J.2    Lu, B.3    Jin, H.4    Kemble, G.5    Subbarao, K.6
  • 33
    • 70349247846 scopus 로고    scopus 로고
    • Partial direct contact transmission in ferrets of a mallard H7N3 influenza virus with typical avian-like receptor specificity
    • Song, H., Wan, H., Araya, Y. & Perez, D. R. Partial direct contact transmission in ferrets of a mallard H7N3 influenza virus with typical avian-like receptor specificity. Virol. J. 6, 126 (2009).
    • (2009) Virol. J. , vol.6 , pp. 126
    • Song, H.1    Wan, H.2    Araya, Y.3    Perez, D.R.4
  • 34
    • 0026060512 scopus 로고
    • Replication of avian influenza viruses in humans
    • Beare, A. S. & Webster, R. G. Replication of avian influenza viruses in humans. Arch. Virol. 119, 37-42 (1991).
    • (1991) Arch. Virol. , vol.119 , pp. 37-42
    • Beare, A.S.1    Webster, R.G.2
  • 35
    • 80052284394 scopus 로고    scopus 로고
    • The ferret as a model organism to study influenza A virus infection
    • Belser, J. A., Katz, J. M. & Tumpey, T. M. The ferret as a model organism to study influenza A virus infection. Dis. Model Mech. 4, 575-579 (2011).
    • (2011) Dis. Model Mech. , vol.4 , pp. 575-579
    • Belser, J.A.1    Katz, J.M.2    Tumpey, T.M.3
  • 37
    • 62549148694 scopus 로고    scopus 로고
    • Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air
    • Van Hoeven, N. et al. Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air. Proc. Natl Acad. Sci. USA 106, 3366-3371 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 3366-3371
    • Van Hoeven, N.1
  • 38
    • 58849167264 scopus 로고    scopus 로고
    • Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets
    • Watanabe, T. et al. Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets. Proc. Natl Acad. Sci. USA 106, 588-592 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 588-592
    • Watanabe, T.1
  • 39
    • 79961092156 scopus 로고    scopus 로고
    • Compatibility ofH9N2 avian influenza surface genes and 2009 pandemic H1N1 internal genes for transmission in the ferret model
    • Kimble, J. B., Sorrell, E.,Shao, H.,Martin, P. L.&Perez, D. R. Compatibility ofH9N2 avian influenza surface genes and 2009 pandemic H1N1 internal genes for transmission in the ferret model. Proc. Natl Acad. Sci. USA 108, 12084-12088 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 12084-12088
    • Kimble, J.B.1    Sorrell, E.2    Shao, H.3    Martin, P.L.4    Perez, D.R.5
  • 40
    • 66149130765 scopus 로고    scopus 로고
    • Minimal molecular constraints for respiratory droplet transmission of an avian-human H9N2 influenza A virus
    • Sorrell, E. M., Wan, H., Araya, Y., Song, H. & Perez, D. R. Minimal molecular constraints for respiratory droplet transmission of an avian-human H9N2 influenza A virus. Proc. Natl Acad. Sci. USA 106, 7565-7570 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 7565-7570
    • Sorrell, E.M.1    Wan, H.2    Araya, Y.3    Song, H.4    Perez, D.R.5
  • 41
    • 84859259700 scopus 로고    scopus 로고
    • Exhaled aerosol transmission of pandemic and seasonal H1N1 influenza viruses in the ferret
    • Koster, F. et al. Exhaled aerosol transmission of pandemic and seasonal H1N1 influenza viruses in the ferret. PLoS ONE 7, e33118 (2012).
    • (2012) PLoS ONE , vol.7
    • Koster, F.1
  • 42
    • 84862166737 scopus 로고    scopus 로고
    • No evidence of horizontal infection in horses kept in close contact with dogs experimentally infected with canine influenza A virus (H3N8)
    • Yamanaka, T. et al. No evidence of horizontal infection in horses kept in close contact with dogs experimentally infected with canine influenza A virus (H3N8). Acta Vet. Scand. 54, 25 (2012).
    • (2012) Acta Vet. Scand. , vol.54 , pp. 25
    • Yamanaka, T.1
  • 43
    • 84871007119 scopus 로고    scopus 로고
    • Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells
    • Mänz, B., Brunotte, L., Reuther, P. & Schwemmle, M. Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells. Nature Commun. 3, 802 (2012).
    • (2012) Nature Commun. , vol.3 , pp. 802
    • Mänz, B.1    Brunotte, L.2    Reuther, P.3    Schwemmle, M.4
  • 44
    • 84855259679 scopus 로고    scopus 로고
    • Eurasian-origin gene segments contribute to the transmissibility aerosol release and morphology of the 2009 pandemic H1N1 influenza virus
    • Lakdawala, S. S. et al. Eurasian-origin gene segments contribute to the transmissibility, aerosol release, and morphology of the 2009 pandemic H1N1 influenza virus. PLoS Pathog. 7, e1002443 (2011).
    • (2011) PLoS Pathog , vol.7
    • Lakdawala, S.S.1
  • 45
    • 60449112576 scopus 로고    scopus 로고
    • Pathological lesions and viral localization of influenza A (H5N1) virus in experimentally infected Chinese rhesus macaques: Implications for pathogenesis and viral transmission
    • Chen, Y. et al. Pathological lesions and viral localization of influenza A (H5N1) virus in experimentally infected Chinese rhesus macaques: implications for pathogenesis and viral transmission. Arch. Virol. 154, 227-233 (2009).
    • (2009) Arch. Virol. , vol.154 , pp. 227-233
    • Chen, Y.1
  • 48
    • 78649902706 scopus 로고    scopus 로고
    • Historical thoughts on influenza viral ecosystems, or behold a pale horse, dead dogs, failing fowl, and sick swine
    • Morens, D. M. & Taubenberger, J. K. Historical thoughts on influenza viral ecosystems, or behold a pale horse, dead dogs, failing fowl, and sick swine. Influenza Other Respir. Viruses 4, 327-337 (2010).
    • (2010) Influenza Other Respir. Viruses , vol.4 , pp. 327-337
    • Morens, D.M.1    Taubenberger, J.K.2
  • 49
    • 33947531139 scopus 로고    scopus 로고
    • Cases of swine influenza in humans: A review of the literature
    • DOI 10.1086/512813
    • Myers, K. P., Olsen, C. W. & Gray, G. C. Cases of swine influenza in humans: a review of the literature. Clin. Infect. Dis. 44, 1084-1088 (2007). (Pubitemid 46580277)
    • (2007) Clinical Infectious Diseases , vol.44 , Issue.8 , pp. 1084-1088
    • Myers, K.P.1    Olsen, C.W.2    Gray, G.C.3
  • 50
    • 67449152290 scopus 로고    scopus 로고
    • Triple-reassortantswine influenzaA (H1) inhumans in theUnited States 2005-2009
    • Shinde, V. et al. Triple-reassortantswine influenzaA (H1) inhumans in theUnited States, 2005-2009. N. Engl. J. Med. 360, 2616-2625 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 2616-2625
    • Shinde, V.1
  • 51
    • 69249211160 scopus 로고    scopus 로고
    • Characterization of the H5N1 highly pathogenic avian influenza virus derived from wild pikas in China
    • Zhou, J. et al. Characterization of the H5N1 highly pathogenic avian influenza virus derived from wild pikas in China. J. Virol. 83, 8957-8964 (2009).
    • (2009) J. Virol. , vol.83 , pp. 8957-8964
    • Zhou, J.1
  • 52
    • 80052026896 scopus 로고    scopus 로고
    • Pandemic influenza: Certain uncertainties
    • Morens, D. M. & Taubenberger, J. K. Pandemic influenza: certain uncertainties. Rev. Med. Virol. 21, 262-284 (2011).
    • (2011) Rev. Med. Virol. , vol.21 , pp. 262-284
    • Morens, D.M.1    Taubenberger, J.K.2
  • 53
    • 79951809198 scopus 로고    scopus 로고
    • The 2009 H1N1 pandemic influenza virus: What next?
    • Morens, D. M., Taubenberger, J. K. & Fauci, A. S. The 2009 H1N1 pandemic influenza virus: what next? MBio 1, 4 (2010).
    • (2010) MBio , vol.1 , pp. 4
    • Morens, D.M.1    Taubenberger, J.K.2    Fauci, A.S.3
  • 55
    • 84863161469 scopus 로고    scopus 로고
    • H5N1 influenza viruses: Facts, not fear
    • Palese, P. & Wang, T. T. H5N1 influenza viruses: facts, not fear. Proc. Natl Acad. Sci. USA 109, 2211-2213 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 2211-2213
    • Palese, P.1    Wang, T.T.2
  • 56
    • 84862777115 scopus 로고    scopus 로고
    • Seroevidence for H5N1 influenza infections in humans: Meta-analysis
    • Wang, T. T., Parides, M. K. & Palese, P. Seroevidence for H5N1 influenza infections in humans: meta-analysis. Science 335, 1463 (2012).
    • (2012) Science , vol.335 , pp. 1463
    • Wang, T.T.1    Parides, M.K.2    Palese, P.3
  • 57
    • 81855205238 scopus 로고    scopus 로고
    • Risk factors for cluster outbreaks of avian influenza A H5N1 infection
    • Aditama, T. Y. et al. Risk factors for cluster outbreaks of avian influenza A H5N1 infection, Indonesia. Clin. Infect. Dis. 53, 1237-1244 (2011).
    • (2011) Indonesia. Clin. Infect. Dis. , vol.53 , pp. 1237-1244
    • Aditama, T.Y.1
  • 58
    • 84855410121 scopus 로고    scopus 로고
    • Avian influenzaH5N1transmission in households Indonesia
    • Aditama, T. Y. et al. Avian influenzaH5N1transmission in households, Indonesia. PLoS ONE 7, e29971 (2012).
    • (2012) PLoS ONE , vol.7
    • Aditama, T.Y.1
  • 60
    • 77957324904 scopus 로고    scopus 로고
    • What is the evidence of a role for host genetics in susceptibility to influenza A/H5N1?
    • Horby, P. et al. What is the evidence of a role for host genetics in susceptibility to influenza A/H5N1? Epidemiol. Infect. 138, 1550-1558 (2010).
    • (2010) Epidemiol. Infect. , vol.138 , pp. 1550-1558
    • Horby, P.1
  • 61
    • 46949084427 scopus 로고    scopus 로고
    • Genetic susceptibility and resistance to influenza infection and disease in humans and mice
    • DOI 10.1586/14737159.8.4.515
    • Trammell, R. A. & Toth, L. A. Genetic susceptibility and resistance to influenza infection and disease in humans and mice. Expert Rev. Mol. Diagn. 8, 515-529 (2008). (Pubitemid 351962094)
    • (2008) Expert Review of Molecular Diagnostics , vol.8 , Issue.4 , pp. 515-529
    • Trammell, R.A.1    Toth, L.A.2
  • 62
    • 70449561448 scopus 로고    scopus 로고
    • Systems-based candidate genes for human response to influenza infection
    • Zhang, L., Katz, J. M., Gwinn, M., Dowling, N. F. & Khoury, M. J. Systems-based candidate genes for human response to influenza infection. Infect. Genet. Evol. 9, 1148-1157 (2009).
    • (2009) Infect. Genet. Evol. , vol.9 , pp. 1148-1157
    • Zhang, L.1    Katz, J.M.2    Gwinn, M.3    Dowling, N.F.4    Khoury, M.J.5
  • 63
    • 84862777209 scopus 로고    scopus 로고
    • IFITM3 restricts the morbidity and mortality associated with influenza
    • Everitt, A. R. et al. IFITM3 restricts the morbidity and mortality associated with influenza. Nature 484, 519-523 (2012).
    • (2012) Nature , vol.484 , pp. 519-523
    • Everitt, A.R.1
  • 64
    • 67650725154 scopus 로고    scopus 로고
    • Safety and immunogenicity of a subvirion inactivated influenza A/H5N1 vaccine with or without aluminum hydroxide among healthy elderly adults
    • Brady, R. C. et al. Safety and immunogenicity of a subvirion inactivated influenza A/H5N1 vaccine with or without aluminum hydroxide among healthy elderly adults. Vaccine 27, 5091-5095 (2009).
    • (2009) Vaccine , vol.27 , pp. 5091-5095
    • Brady, R.C.1
  • 65
    • 0032735685 scopus 로고    scopus 로고
    • Antibody response in individuals infected with avian influenza A (H5N1) viruses and detection of anti-H5 antibody among household and social contacts
    • Katz, J. M. et al. Antibody response in individuals infected with avian influenza A (H5N1) viruses and detection of anti-H5 antibody among household and social contacts. J. Infect. Dis. 180, 1763-1770 (1999).
    • (1999) J. Infect. Dis. , vol.180 , pp. 1763-1770
    • Katz, J.M.1
  • 66
    • 82355180932 scopus 로고    scopus 로고
    • In vitro evolution of H5N1 avian influenza virus toward humantype receptor specificity
    • Chen, L. M. et al. In vitro evolution of H5N1 avian influenza virus toward humantype receptor specificity. Virology 422, 105-113 (2012).
    • (2012) Virology , vol.422 , pp. 105-113
    • Chen, L.M.1
  • 67
    • 79953101262 scopus 로고    scopus 로고
    • Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 viruses
    • Maines, T. R. et al. Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 viruses. Virology 413, 139-147 (2011).
    • (2011) Virology , vol.413 , pp. 139-147
    • Maines, T.R.1
  • 68
    • 59249096926 scopus 로고    scopus 로고
    • Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N
    • Steel, J., Lowen, A. C., Mubareka, S.& Palese, P. Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N. PLoS Pathog. 5, e1000252 (2009).
    • (2009) PLoS Pathog , vol.5
    • Steel, J.1    Lowen, A.C.2    Mubareka, S.3    Palese, P.4
  • 69
    • 43049120664 scopus 로고    scopus 로고
    • Humanlike receptor specificity does not affect the neuraminidase- inhibitor susceptibility of H5N1 influenza viruses
    • Ilyushina, N. A., Govorkova, E. A., Gray, T. E., Bovin, N. V. & Webster, R. G. Humanlike receptor specificity does not affect the neuraminidase-inhibitor susceptibility of H5N1 influenza viruses. PLoS Pathog. 4, e1000043 (2008).
    • (2008) PLoS Pathog , vol.4
    • Ilyushina, N.A.1    Govorkova, E.A.2    Gray, T.E.3    Bovin, N.V.4    Webster, R.G.5
  • 71
    • 58549110104 scopus 로고    scopus 로고
    • Changes in H5N1influenza virus hemagglutinin receptor binding domain affect systemic spread
    • Yen, H. L. et al. Changes in H5N1influenza virus hemagglutinin receptor binding domain affect systemic spread. Proc. Natl Acad. Sci. USA 106, 286-291 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 286-291
    • Yen, H.L.1
  • 72
    • 77953932654 scopus 로고    scopus 로고
    • Antigenic epitopes in the hemagglutinin of Qinghai-type influenza H5N1 virus
    • Rudneva, I. A. et al. Antigenic epitopes in the hemagglutinin of Qinghai-type influenza H5N1 virus. Viral Immunol. 23, 181-187 (2010).
    • (2010) Viral Immunol. , vol.23 , pp. 181-187
    • Rudneva, I.A.1
  • 73
    • 77953297916 scopus 로고    scopus 로고
    • Glycosylation at 158N of the hemagglutinin protein and receptor binding specificity synergistically affect the antigenicity and immunogenicity of a live attenuated H5N1 A/Vietnam/1203/2004 vaccine virus in ferrets
    • Wang, W. et al. Glycosylation at 158N of the hemagglutinin protein and receptor binding specificity synergistically affect the antigenicity and immunogenicity of a live attenuated H5N1 A/Vietnam/1203/2004 vaccine virus in ferrets. J. Virol. 84, 6570-6577 (2010).
    • (2010) J. Virol. , vol.84 , pp. 6570-6577
    • Wang, W.1
  • 74
    • 62049083943 scopus 로고    scopus 로고
    • Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses
    • Sui, J. et al. Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses. Nature Struct. Mol. Biol. 16, 265-273 (2009).
    • (2009) Nature Struct. Mol. Biol. , vol.16 , pp. 265-273
    • Sui, J.1
  • 75
    • 77955622860 scopus 로고    scopus 로고
    • Highly pathogenic H5N1 influenza viruses carry virulence determinants beyond the polybasic hemagglutinin cleavage site
    • Bogs, J. et al. Highly pathogenic H5N1 influenza viruses carry virulence determinants beyond the polybasic hemagglutinin cleavage site. PLoS ONE 5, e11826 (2010).
    • (2010) PLoS ONE , vol.5
    • Bogs, J.1
  • 76
    • 78651253699 scopus 로고    scopus 로고
    • Amino acids adjacent to the haemagglutinin cleavage site are relevant for virulence of avian influenza viruses of subtype H5
    • Gohrbandt, S. et al.Amino acids adjacent to the haemagglutinin cleavage site are relevant for virulence of avian influenza viruses of subtype H5. J. Gen. Virol. 92, 51-59 (2011).
    • (2011) J. Gen. Virol. , vol.92 , pp. 51-59
    • Gohrbandt, S.1
  • 77
    • 84857863488 scopus 로고    scopus 로고
    • Themultibasic cleavage site of the hemagglutinin of highly pathogenic A/Vietnam/1203/2004 H5N1) avian influenza virus acts as a virulence factor in a host-specific manner in mammals
    • Suguitan, A. L. Jr et al. Themultibasic cleavage site of the hemagglutinin of highly pathogenic A/Vietnam/1203/2004 (H5N1) avian influenza virus acts as a virulence factor in a host-specific manner in mammals. J. Virol. 86, 2706-2714 (2012).
    • (2012) J. Virol. , vol.86 , pp. 2706-2714
    • Suguitan Jr., A.L.1
  • 78
    • 0036734038 scopus 로고    scopus 로고
    • Lethal H5N1 influenza viruses escape host anti-viral cytokine responses
    • DOI 10.1038/nm757
    • Seo, S. H., Hoffmann, E. & Webster, R. G. Lethal H5N1 influenza viruses escape host anti-viral cytokine responses. Nature Med. 8, 950-954 (2002). (Pubitemid 35033698)
    • (2002) Nature Medicine , vol.8 , Issue.9 , pp. 950-954
    • Seo, S.H.1    Hoffmann, E.2    Webster, R.G.3
  • 79
    • 79960403406 scopus 로고    scopus 로고
    • The virulence of 1997 H5N1 influenza viruses in the mouse model is increased by correcting a defect in their NS1 proteins
    • Spesock, A. et al. The virulence of 1997 H5N1 influenza viruses in the mouse model is increased by correcting a defect in their NS1 proteins. J. Virol. 85, 7048-7058 (2011).
    • (2011) J. Virol. , vol.85 , pp. 7048-7058
    • Spesock, A.1
  • 80
    • 77957201252 scopus 로고    scopus 로고
    • Virulence determinants of avian H5N1 influenza A virus in mammalian and avian hosts: Role of the C-terminal ESEV motif in the viral NS1 protein
    • Zielecki, F. et al. Virulence determinants of avian H5N1 influenza A virus in mammalian and avian hosts: role of the C-terminal ESEV motif in the viral NS1 protein. J. Virol. 84, 10708-10718 (2010).
    • (2010) J. Virol. , vol.84 , pp. 10708-10718
    • Zielecki, F.1
  • 81
    • 84861411482 scopus 로고    scopus 로고
    • Five easy mutations to make bird flu a lethal pandemic
    • MacKenzie, D. Five easy mutations to make bird flu a lethal pandemic. New Sci. http://www.newscientist.com/article/mg21128314.600-five-easy-mutationsto- make-bird-flu-a-lethal-pandemic.html (2011).
    • (2011) New Sci
    • MacKenzie, D.1
  • 85
    • 84862547361 scopus 로고    scopus 로고
    • Censoring flu data could raise bioterror threat
    • MacKenzie, D. Censoring flu data could raise bioterror threat. New Sci. http://www.newscientist.com/article/dn21675-censoring-flu-data-could- raisebioterror-threat.html (2012).
    • (2012) New Sci
    • MacKenzie, D.1
  • 88
    • 82455171694 scopus 로고    scopus 로고
    • Potential role of human challenge studies for investigation of influenza transmission
    • Killingley, B. et al. Potential role of human challenge studies for investigation of influenza transmission. Lancet Infect. Dis. 11, 879-886 (2011).
    • (2011) Lancet Infect. Dis. , vol.11 , pp. 879-886
    • Killingley, B.1
  • 92
    • 79751481510 scopus 로고    scopus 로고
    • Multidrug-resistant 2009 pandemic influenza A(H1N1) viruses maintain fitness and transmissibility in ferrets
    • Memoli, M. J. et al. Multidrug-resistant 2009 pandemic influenza A(H1N1) viruses maintain fitness and transmissibility in ferrets. J. Infect. Dis. 203, 348-357 (2011).
    • (2011) J. Infect. Dis. , vol.203 , pp. 348-357
    • Memoli, M.J.1
  • 93
    • 77955293563 scopus 로고    scopus 로고
    • Receptor specificity and transmission of H2N2 subtype viruses isolated from the pandemic of 1957
    • Pappas, C. et al. Receptor specificity and transmission of H2N2 subtype viruses isolated from the pandemic of 1957. PLoS ONE 5, e11158 (2010).
    • (2010) PLoS ONE , vol.5
    • Pappas, C.1
  • 94
    • 81555208102 scopus 로고    scopus 로고
    • Insights on influenza pathogenesis from the grave
    • Taubenberger, J. K. & Kash, J. C. Insights on influenza pathogenesis from the grave. Virus Res. 162, 2-7 (2011).
    • (2011) Virus Res. , vol.162 , pp. 2-7
    • Taubenberger, J.K.1    Kash, J.C.2
  • 95
  • 97
    • 79956017135 scopus 로고    scopus 로고
    • Computational design of proteins targeting the conserved stem region of influenza hemagglutinin
    • Fleishman, S. J. et al. Computational design of proteins targeting the conserved stem region of influenza hemagglutinin. Science 332, 816-821 (2011).
    • (2011) Science , vol.332 , pp. 816-821
    • Fleishman, S.J.1
  • 101
    • 79952621304 scopus 로고    scopus 로고
    • The ability ofpandemic influenza virus hemagglutinins to induce lower respiratory pathology is associated with decreased surfactant proteinD binding
    • Qi, L. et al. The ability ofpandemic influenza virus hemagglutinins to induce lower respiratory pathology is associated with decreased surfactant proteinD binding. Virology 412, 426-434 (2011).
    • (2011) Virology , vol.412 , pp. 426-434
    • Qi, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.