Highly pathogenic H5N1 influenza viruses carry virulence determinants beyond the polybasic hemagglutinin cleavage site

PLoS ONE

Volumn 5, Issue 7, 2010, Pages

  Bogs, Jessica ^a   Veits, Jutta ^a   Gohrbandt, Sandra ^a   Hundt, Jana ^a   Stech, Olga ^a   Breithaupt, Angele ^a   Teifke, Jens P ^a   Mettenleiter, Thomas C ^a   Stech, Jürgen ^a  

^a FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA VIRUS HEMAGGLUTININ; MUTANT PROTEIN; TRYPSIN; VIRUS ENVELOPE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AVIAN INFLUENZA VIRUS; BRAIN; CECUM; CELL INFILTRATION; CEREBELLUM; CONTROLLED STUDY; DEPRESSION; DIARRHEA; DUODENUM; ENDOTHELIUM CELL; EXPERIMENTAL INFECTION; FEATHER; GENE MUTATION; GENETIC ENGINEERING; GENETIC REASSORTMENT; HUMAN; HUMAN CELL; INFLAMMATORY CELL; INFLUENZA A (H5N1); INFLUENZA VIRUS A H5N1; KIDNEY; LETHALITY; LUNG; LUNG ALVEOLUS CELL TYPE 2; LYMPHOCYTE; MACROPHAGE; MORBIDITY; MORTALITY; NEUROTROPISM; NONHUMAN; NOSE MUCOSA; NUCLEOTIDE SEQUENCE; PANCREAS; PROTEIN CLEAVAGE; PROTEIN MOTIF; SURVIVAL; TRACHEA; VIRUS GENE; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS STRAIN; VIRUS TRANSFORMATION; VIRUS VIRULENCE; ANIMAL; CELL LINE; CHICKEN; DOG; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOGENICITY; VIRULENCE; WESTERN BLOTTING;

ANIMALIA; AVES; AVIAN INFLUENZA VIRUS; GALLUS GALLUS; ORTHOMYXOVIRIDAE;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CHICKENS; DOGS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; IMMUNOHISTOCHEMISTRY; INFLUENZA A VIRUS, H5N1 SUBTYPE; VIRAL ENVELOPE PROTEINS; VIRULENCE;

EID: 77955622860     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011826     Document Type: Article

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