Expression of the notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas

American Journal of Pathology

Volumn 169, Issue 4, 2006, Pages 1206-1214

  Rooman, Ilse ^a,b   De Medts, Nele ^a   Baeyens, Luc ^a   Lardon, Jessy ^a   De Breuck, Saskia ^a   Heimberg, Harry ^a   Bouwens, Luc ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b DIABETES RESEARCH CENTER   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; PROTEIN P21; PROTEIN P48; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR PDX 1; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CYCLIN DEPENDENT KINASE INHIBITOR 1A; HAIRY, HRT1 PROTEIN; HES1 PROTEIN, RAT; HOMEODOMAIN PROTEIN; INSULIN PROMOTER FACTOR 1; MIST1 PROTEIN, RAT; REPRESSOR PROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PTF1;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; EXOCRINE CELL; MALE; METAPLASIA; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; UPREGULATION; ANIMAL; CHEMISTRY; GENETICS; LIGATION; METABOLISM; PANCREAS; PANCREAS DUCT; PATHOLOGY; SIGNAL TRANSDUCTION; WISTAR RAT;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; HOMEODOMAIN PROTEINS; LIGATION; MALE; METAPLASIA; PANCREAS, EXOCRINE; PANCREATIC DUCTS; RATS; RATS, WISTAR; RECEPTORS, NOTCH; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 35349021929     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2006.050926     Document Type: Article

References (50)

1. Bockman DE: Toward understanding pancreatic disease: from architecture to cell signaling. Pancreas 1995, 11:324-329
2. Bouwens L: Transdifferentiation versus stem cell hypothesis for the regeneration of islet beta-cells in the pancreas. Microsc Res Tech 1998, 43:332-336
3. Lardon J, Bouwens L: Metaplasia in the pancreas. Differentiation 2005, 73:278-286
4. Schmid RM: Acinar-to-ductal metaplasia in pancreatic cancer development. J Clin Invest 2002, 109:1403-1404
5. Wang RN, Klöppel G, Bouwens L: Duct to islet cell differentiation and islet growth in the pancreas of duct ligated adult rats. Diabetologia 1995, 38:1405-1411
6. Rooman I, Lardon J, Flamez D, Schuit F, Bouwens L: Mitogenic effect of gastrin and expression of gastrin receptors in duct-like cells of rat pancreas. Gastroenterology 2001, 121:940-949
7. Rooman I, Lardon J, Bouwens L: Gastrin stimulates β-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue. Diabetes 2002, 51:686-690
8. Mathieu A, Clerc P, Portolan G, Bierkamp C, Lulka H, Pradayrol L, Seva C, Fourmy D, Dufresne M: Transgenic expression of CCK2 receptors sensitizes murine pancreatic acinar cells to carcinogen-induced preneoplastic lesions formation. Int J Cancer 2005, 115:46-54
9. Wang RN, Rehfeld JF, Nielsen FC, Kloppel G: Expression of gastrin and transforming growth factor-alpha during duct to islet cell differentiation in the pancreas of duct-ligated adult rats. Diabetologia 1997, 40:887-893
10. Rooman I, Heremans Y, Heimberg H, Bouwens L: Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro. Diabetologia 2000, 43:907-914
11. Lardon J, De Breuck S, Rooman I, Van Lommel L, Kruhoffer M, Orntoft T, Schuit F, Bouwens L: Plasticity in the adult rat pancreas: transdifferentiation of exocrine to hepatocyte-like cells in primary culture. Hepatology 2004, 39:1499-1507
12. Baeyens L, De Breuck S, Lardon J, Kunjom JM, Rooman I, Bouwens L: In vitro generation of insulin-producing beta-cells from adult exocrine pancreatic cells. Diabetologia 2005, 48:49-57
13. Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, Honjo T, Hrabe de Angelis M, Lendahl U, Edlund H: Notch signaling controls pancreatic cell differentiation. Nature 1999, 400:877-881
14. Lammert E, Brown J, Melton DA: Notch gene expression during pancreatic organogenesis. Mech Dev 2000, 94:199-203
15. Jensen J, Pedersen EE, Galante P, Hald J, Heller RS, Ishibashi M, Kageyama R, Guillemot F, Serup P, Madsen OD: Control of endodermal endocrine development by Hes-1. Nat Genet 2000, 24:36-44
16. Hald J, Hjorth P, German MS, Madsen OD, Serup P, Jensen J: Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev Biol 2003, 260:426-437
17. Murtaugh LC, Stanger BZ, Kwan KM, Melton DA: Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci USA 2003, 100:14920-14925
18. Miyamoto Y, Maitra A, Ghosh B, Zechner U, Argani P, Iacobuzio-Donahue CA, Sriuranpong V, Iso T, Meszoely IM, Wolfe MS, Hruban RH, Ball DW, Schmid RM, Leach SD: Notch mediates TGFa-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell 2003, 3:565-576
19. Jensen JN, Cameron E, Garay MVR, Starkey TW, Gianani R, Jensen J: Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration. Gastroenterology 2005, 128:728-741
20. Murata-Oshawa M, Tohda S, Sakano S, Nara N: The Notch ligand, delta-1, partially inhibits GM-CSF-induced differentiation and apoptosis along with reducing the cleavage of PARP in U937 cells. Int J Mol Med 2004, 13:419-423
21. Bouwens L, Wang RN, De Blay E, Pipeleers DG, Klöppel G: Cytokeratins as markers of ductal cell differentiation and islet neogenesis in the neonatal rat pancreas. Diabetes 1994, 43:1279-1283
22. Adell T, Gómez-Cuadrado A, Skoudy A, Pettengill OS, Longnecker DS, Real FX: Role of the helix-loop-helix transcription factor p48 in the differentiation phenotype of exocrine pancreas cancer cells. Cell Growth Differ 2000, 11:137-147
23. Pin CL, Bonvissuto AC, Konieczny SF: Mist1 expression is a common link among serous exocrine cells exhibiting regulated exocytosis. Anat Rec 2000, 259:157-167
24. Oster A, Jensen J, Serup P, Galante P, Madsen OD, Larsson LI: Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1). J Histochem Cytochem 1998, 46:707-715
25. Ito T, Udaka N, Yazawa T, Okudela K, Hayashi H, Sudo T, Guillemot F, Kageyama R, Kitamura H: Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium. Development 2000, 127:3913-3921
26. Martys-Zage JL, Kim SH, Berechid B, Bingham SJ, Chu S, Sklar J, Nye J, Sisodia SS: Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1. J Mol Neurosci 2000, 15:189-204
27. Weidemann A, Eggert S, Reinhard FB, Vogel M, Paliga K, Baier G, Masters CL, Beyreuther K, Evin G: A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing. Biochemistry 2002, 41:2825-2835
28. Minami K, Okuno M, Miyawaki K, Okumachi A, Ishizaki K, Oyama K, Kawaguchi M, Ishizuka N, Iwanaga T, Seino S: Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. Proc Natl Acad Sci USA 2005, 102:15116-15121
29. Zhu L, Tran T, Rukstalis M, Sun P, Damsz B, Konieczny SF: Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia. Mol Cell Biol 2004, 24:2673-2681
30. Rodolosse A, Chalaux E, Adell T, Hagège H, Skoudy A, Real FX: PTF1a/p48 and cell proliferation. Gastroenterology 2004, 127:937-949
31. Sharma A, Zangen DH, Reitz P, Taneja M, Lissauer ME, Miller CP, Weir GC, Habener JF, Bonner-Weir S: The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes 1999, 48:507-513
32. Kritzik MR, Krahl T, Good A, Krakowski M, St-Onge L, Gruss P, Wright C, Sarvetnick N: Transcription factor expression during pancreatic islet regeneration. Mol Cell Endocrinol 2000, 164:99-107
33. Norgaard GA, Jensen JN, Jensen J: FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of notch in organ development. Dev Biol 2003, 264:323-338
34. Esni F, Ghosh B, Biankin AV, Lin JW, Albert MA, Yu X, MacDonald RJ, Civin CI, Real FX, Pack MA, Ball DW, Leach SD: Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas. Development 2004, 131:4213-4224
35. Lardon J, Huyens N, Rooman I, Bouwens L: Exocrine cell transdifferentiation in dexamethasone-treated rat pancreas. Virchows Arch 2004, 444:61-65
36. Iso T, Kedes L, Hamamori Y: Hes and Herp families: multiple effectors of the Notch signaling pathway. J Cell Physiol 2003, 194:237-255
37. Hu QD, Ang BT, Karsak M, Hu WP, Cui XY, Duka T, Takeda Y, Chia W, Sankar N, Ng YK, Ling EA, Maciag T, Small D, Trifonova R, Kopan R, Okano H, Nakafuku M, Chiba S, Hirai H, Aster JC, Schachner M, Pallen CJ, Watanabe K, Xiao ZC: F3/contactin acts as a functional ligand for notch during oligodendrocyte maturation. Cell 2003, 115:163-175
38. Cattaneo M, Orlandi R, Ronchini C, Granelli P, Malferrari G, Menard S, Biunno I: The expression of SEL1L and TAN-1 in normal and neoplastic cells. Int J Biol Markers 2000, 15:26-32
39. Chojnacki A, Shimazaki T, Gregg C, Weinmaster G, Weiss S: Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells. J Neurosci 2003, 23:1730-1741
40. De Breuck S, Baeyens L, Bouwens L: Expression and function of leukemia inhibitory factor and its receptor in normal and regenerating rat pancreas. Diabetologia 2006, 49:108-116
41. Sriuranpong V, Borges MW, Ravi RK, Arnold DR, Nelkin BD, Baylin SB, Ball DW: Notch signaling induces cell cycle arrest in small cell lung cancer cells. Cancer Res 2001, 61:3200-3205
42. Aguilera C, Hoya-Arias R, Haegeman G, Espinosa L, Bigas A: Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression. Proc Natl Acad Sci USA 2004, 101:16537-16542
43. Walker L, Lynch M, Silverman S, Fraser J, Boulter J, Weinmaster G, Gasson JC: The notch/jagged pathway inhibits proliferation of human hematopoetic progenitors in vitro. Stem cells 1999, 17:162-171
44. Watanabe N, Tezuka Y, Matsuno K, Miyatani S, Morimura N, Yasuda M, Fujimaki R, Kuroda K, Hiraki Y, Hozumi N, Tezuka K: Suppression of differentiation and proliferation of early chondrogenic cells by Notch. J Bone Miner Metab 2003, 21:344-352
45. Taylor KL, Henderson HM, Hughes CC: Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression. Microvasc Res 2002, 64:372-383
46. Castella P, Sawai S, Nakao K, Wagner JA, Caudy M: HES-1 repression of differentiation and proliferation in PC12 cells: role for the helix 3-helix 4 domain in transcription repression. Mol Cell Biol 2000, 20:6170-6183
47. Noseda M, Chang L, McLean G, Grim JE, Clurman BE, Smith LL, Karsan A: Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21CIP1 repression. Mol Cell Biol 2004, 24:8813-8822
48. WAF1/CIP1 is an early event in the development of pancreatic intraepithelial neoplasia. Cancer Res 2001, 61:8830-8837
49. Köhler C, Bell AW, Bowen WC, Monga SP, Fleig W, Michalopoulos GK: Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration. Hepatology 2004, 39:1056-1065
50. Conboy IM, Conboy MJ, Smythe GM, Rando TA: Notch-mediated restoration of regenerative potential to aged muscle. Science 2003, 302:1575-1577