Structural, kinetic, and thermodynamic analysis of glucoimidazole-derived glycosidase inhibitors

Biochemistry

Volumn 45, Issue 39, 2006, Pages 11879-11884

  Gloster, Tracey M ^a   Roberts, Shirley ^a   Perugino, Giuseppe ^b   Rossi, Mosè ^b   Moracci, Marco ^b   Panday, Narendra ^c   Terinek, Miroslav ^c   Vasella, Andrea ^c   Davies, Gideon J ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b INSTITUTE OF PROTEIN BIOCHEMISTRY   (Italy)

^c ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; DRUG PRODUCTS; STRUCTURAL ANALYSIS; SUBSTITUTION REACTIONS; THERMODYNAMICS; VIRUSES;

GLUCOIMIDAZOLE; GLYCOSIDASE INHIBITORS; VIRAL INFECTIONS;

ENZYMES;

BETA GLYCOSIDASE; GLUCOIMIDAZOLE DERIVATIVE; GLYCOSIDASE; GLYCOSIDASE INHIBITOR; IMIDAZOLE DERIVATIVE; PHENETHYLIMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER; COVALENT BOND; DIABETES MELLITUS; DRUG DESIGN; DRUG EFFICACY; DRUG SPECIFICITY; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS; THREE DIMENSIONAL IMAGING; VIRUS INFECTION;

ARCHAEAL PROTEINS; BACTERIAL PROTEINS; BETA-GLUCOSIDASE; ENZYME INHIBITORS; GLUCOSE; HUMANS; IMIDAZOLES; KINETICS; MOLECULAR STRUCTURE; NEOPLASM PROTEINS; NEOPLASMS; PROTEIN BINDING; SULFOLOBUS SOLFATARICUS; THERMODYNAMICS; THERMOTOGA MARITIMA;

EID: 33749321259     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060973x     Document Type: Article

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