Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Yueh, Mei Fei ^a   Li, Tao ^a   Evans, Ronald M ^a   Hammock, Bruce ^b   Tukey, Robert H ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 1B1; CYTOCHROME P450 2B6; ESTROGEN RECEPTOR ALPHA; MESSENGER RNA; SMALL INTERFERING RNA; TRICLOCARBAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; CONTROLLED STUDY; CYP1B1 GENE; CYP2B10 GENE; CYP2B6 GENE; ENVIRONMENTAL EXPOSURE; ENZYME ASSAY; FEMALE; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE INDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; MOUSE; NONHUMAN; PROTEIN FUNCTION; REVERSE GENETICS; STEROID METABOLISM; TRANSCRIPTION REGULATION; UGT1A GENE; XENOBIOTIC METABOLISM;

ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; ARYL HYDROCARBON HYDROXYLASES; BLOTTING, WESTERN; CARBANILIDES; CELLS, CULTURED; ESTROGEN RECEPTOR ALPHA; FEMALE; GENE EXPRESSION REGULATION; GLUCURONOSYLTRANSFERASE; HUMANS; IMMUNOENZYME TECHNIQUES; METABOLIC DETOXICATION, DRUG; MICE; MICROSOMES, LIVER; OVARY; OXIDOREDUCTASES, N-DEMETHYLATING; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; XENOBIOTICS;

EID: 84862489707     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037705     Document Type: Article

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