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Volumn 299, Issue 1, 2012, Pages 10-19

Mono-(2-ethylhexyl)-phthalate (MEHP) affects ERK-dependent GDNF signalling in mouse stem-progenitor spermatogonia

Author keywords

GDNF; Infertility; Phthalates; Self renewal; Spermatogonial stem cells

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; PROTEIN FOS; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE;

EID: 84862332247     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.04.011     Document Type: Article
Times cited : (41)

References (81)
  • 2
    • 33749659139 scopus 로고    scopus 로고
    • A dose response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): reproductive effects on adult male offspring rats
    • Andrade A.J., Grande S.W., Talsness C.E., Gericke C., Grote K., Golombiewski A., Sterner-Kock A., Chahoud I. A dose response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): reproductive effects on adult male offspring rats. Toxicology 2006, 228:85-97.
    • (2006) Toxicology , vol.228 , pp. 85-97
    • Andrade, A.J.1    Grande, S.W.2    Talsness, C.E.3    Gericke, C.4    Grote, K.5    Golombiewski, A.6    Sterner-Kock, A.7    Chahoud, I.8
  • 3
    • 0028918122 scopus 로고
    • Decline in semen quality among fertile men in Paris during the past 20 years
    • Auger J., Kunstmann J.M., Czyglik F., Jouannet P. Decline in semen quality among fertile men in Paris during the past 20 years. N. Engl. J. Med. 1995, 332:281-285.
    • (1995) N. Engl. J. Med. , vol.332 , pp. 281-285
    • Auger, J.1    Kunstmann, J.M.2    Czyglik, F.3    Jouannet, P.4
  • 9
    • 77949572961 scopus 로고    scopus 로고
    • Phthalate exposure and asthma in children
    • Bornehag C.G., Nanberg E. Phthalate exposure and asthma in children. Int. J. Androl. 2010, 33:333-345.
    • (2010) Int. J. Androl. , vol.33 , pp. 333-345
    • Bornehag, C.G.1    Nanberg, E.2
  • 10
    • 33947139666 scopus 로고    scopus 로고
    • Role of Src family kinases and N-Myc in spermatogonial stem cell proliferation
    • Braydich-Stolle L., Kostereva N., Dym M., Hofmann M.C. Role of Src family kinases and N-Myc in spermatogonial stem cell proliferation. Dev. Biol. 2007, 304:34-45.
    • (2007) Dev. Biol. , vol.304 , pp. 34-45
    • Braydich-Stolle, L.1    Kostereva, N.2    Dym, M.3    Hofmann, M.C.4
  • 11
    • 32244437467 scopus 로고    scopus 로고
    • Role of glial cell line-derived neurotrophic factor in germ-line stem cell fate
    • Braydich-Stolle L., Nolan C., Dym M., Hofmann M.C. Role of glial cell line-derived neurotrophic factor in germ-line stem cell fate. Ann. N.Y. Acad. Sci. 2005, 1061:94-99.
    • (2005) Ann. N.Y. Acad. Sci. , vol.1061 , pp. 94-99
    • Braydich-Stolle, L.1    Nolan, C.2    Dym, M.3    Hofmann, M.C.4
  • 13
    • 0022837587 scopus 로고
    • The decline of the gastropod Nucella lapillus around southwest England: evidence for the effect of tributyltin from antifouling paints
    • Bryan G.W., Gibbs P.E., Hummerstone L.G., Burt G.R. The decline of the gastropod Nucella lapillus around southwest England: evidence for the effect of tributyltin from antifouling paints. J. Mar. Biol. Assoc. U.K. 1986, 66:611-640.
    • (1986) J. Mar. Biol. Assoc. U.K. , vol.66 , pp. 611-640
    • Bryan, G.W.1    Gibbs, P.E.2    Hummerstone, L.G.3    Burt, G.R.4
  • 14
    • 0026657024 scopus 로고
    • Evidence for decreasing quality of semen during past 50 years
    • Carlsen E., Giwercman A., Keiding N., Skakkebaek N.E. Evidence for decreasing quality of semen during past 50 years. BMJ 1992, 305:609-613.
    • (1992) BMJ , vol.305 , pp. 609-613
    • Carlsen, E.1    Giwercman, A.2    Keiding, N.3    Skakkebaek, N.E.4
  • 16
    • 72049112300 scopus 로고    scopus 로고
    • Assessing the relevance of in vitro measures of phthalate inhibition of steroidogenesis for in vivo response
    • Clewell R.A., Campbell J.L., Ross S.M., Gaido K.W., Clewell H.J., Andersen M.E. Assessing the relevance of in vitro measures of phthalate inhibition of steroidogenesis for in vivo response. Toxicol. In Vitro 2010, 24:327-334.
    • (2010) Toxicol. In Vitro , vol.24 , pp. 327-334
    • Clewell, R.A.1    Campbell, J.L.2    Ross, S.M.3    Gaido, K.W.4    Clewell, H.J.5    Andersen, M.E.6
  • 17
    • 0031971972 scopus 로고    scopus 로고
    • Stem cells in the testis
    • De Rooij D.G. Stem cells in the testis. Int. J. Exp. Pathol. 1998, 79:67-80.
    • (1998) Int. J. Exp. Pathol. , vol.79 , pp. 67-80
    • De Rooij, D.G.1
  • 18
    • 73349090951 scopus 로고    scopus 로고
    • The transcription factor Fos: a Janus-type regulator in health and disease
    • Durchdewald M., Angel P., Hess J. The transcription factor Fos: a Janus-type regulator in health and disease. Histol. Histopathol. 2009, 24:1451-1461.
    • (2009) Histol. Histopathol. , vol.24 , pp. 1451-1461
    • Durchdewald, M.1    Angel, P.2    Hess, J.3
  • 20
    • 1242275292 scopus 로고    scopus 로고
    • The relationship between environmental exposure to phthalates and computer-aided sperm analysis motion parameters
    • Duty S.M., Calafat A.M., Silva M.J., Brock J.W., Ryan L., Chen Z., Overstreet J., Hauser R. The relationship between environmental exposure to phthalates and computer-aided sperm analysis motion parameters. J. Androl. 2004, 25:293-302.
    • (2004) J. Androl. , vol.25 , pp. 293-302
    • Duty, S.M.1    Calafat, A.M.2    Silva, M.J.3    Brock, J.W.4    Ryan, L.5    Chen, Z.6    Overstreet, J.7    Hauser, R.8
  • 21
    • 0023265896 scopus 로고
    • Changes in hepatic dolichol and dolichyl monophosphate caused by treatment of rats with inducers of the endoplasmic reticulum and peroxisomes and during ontogeny
    • Edlund C., Ericsson J., Dallner G. Changes in hepatic dolichol and dolichyl monophosphate caused by treatment of rats with inducers of the endoplasmic reticulum and peroxisomes and during ontogeny. Chem. Biol. Interact. 1987, 62:191-208.
    • (1987) Chem. Biol. Interact. , vol.62 , pp. 191-208
    • Edlund, C.1    Ericsson, J.2    Dallner, G.3
  • 22
    • 77954511322 scopus 로고    scopus 로고
    • Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells
    • Erkekoglu P., Rachidi W., De Rosa V., Giray B., Favier A., Hincal F. Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells. Free Radic. Biol. Med. 2010, 49:559-566.
    • (2010) Free Radic. Biol. Med. , vol.49 , pp. 559-566
    • Erkekoglu, P.1    Rachidi, W.2    De Rosa, V.3    Giray, B.4    Favier, A.5    Hincal, F.6
  • 23
    • 33751241130 scopus 로고    scopus 로고
    • Acute and long-term effects of in utero exposure of rats to di(n-butyl) phthalate on testicular germ cell development and proliferation
    • Ferrara D., Hallmark N., Scott H., Brown R., McKinnell C., Mahood I.K., Sharpe R.M. Acute and long-term effects of in utero exposure of rats to di(n-butyl) phthalate on testicular germ cell development and proliferation. Endocrinology 2006, 147:5352-5362.
    • (2006) Endocrinology , vol.147 , pp. 5352-5362
    • Ferrara, D.1    Hallmark, N.2    Scott, H.3    Brown, R.4    McKinnell, C.5    Mahood, I.K.6    Sharpe, R.M.7
  • 24
    • 0038575340 scopus 로고    scopus 로고
    • Human 'testicular dysgenesis syndrome': a possible model using in-utero exposure of the rat to dibutyl phthalate
    • Fisher J.S., Macpherson S., Marchetti N., Sharpe R.M. Human 'testicular dysgenesis syndrome': a possible model using in-utero exposure of the rat to dibutyl phthalate. Hum. Reprod. 2003, 18:1383-1394.
    • (2003) Hum. Reprod. , vol.18 , pp. 1383-1394
    • Fisher, J.S.1    Macpherson, S.2    Marchetti, N.3    Sharpe, R.M.4
  • 25
    • 78651357971 scopus 로고    scopus 로고
    • Correlations between phthalate metabolites in urine, serum, and seminal plasma from young Danish men determined by isotope dilution liquid chromatography tandem mass spectrometry
    • Frederiksen H., Jørgensen N., Andersson A.-M. Correlations between phthalate metabolites in urine, serum, and seminal plasma from young Danish men determined by isotope dilution liquid chromatography tandem mass spectrometry. J. Anal. Toxicol. 2010, 34:400-410.
    • (2010) J. Anal. Toxicol. , vol.34 , pp. 400-410
    • Frederiksen, H.1    Jørgensen, N.2    Andersson, A.-M.3
  • 28
    • 38349052363 scopus 로고    scopus 로고
    • Gdnf upregulates c-Fos transcription via the Ras/Erk1/2 pathway to promote mouse spermatogonial stem cell proliferation
    • He Z., Jiang J., Kokkinaki M., Golestaneh N., Hofmann M.C., Dym M. Gdnf upregulates c-Fos transcription via the Ras/Erk1/2 pathway to promote mouse spermatogonial stem cell proliferation. Stem Cells 2008, 26:266-278.
    • (2008) Stem Cells , vol.26 , pp. 266-278
    • He, Z.1    Jiang, J.2    Kokkinaki, M.3    Golestaneh, N.4    Hofmann, M.C.5    Dym, M.6
  • 30
    • 60749127831 scopus 로고    scopus 로고
    • Concentrations of phthalate metabolites in milk, urine, saliva, and serum of lactating North Carolina women
    • Hines E.P., Calafat A.M., Silva M.J., Mendola P., Fenton S.E. Concentrations of phthalate metabolites in milk, urine, saliva, and serum of lactating North Carolina women. Environ. Health Perspect. 2009, 117:86-92.
    • (2009) Environ. Health Perspect. , vol.117 , pp. 86-92
    • Hines, E.P.1    Calafat, A.M.2    Silva, M.J.3    Mendola, P.4    Fenton, S.E.5
  • 32
    • 13544252606 scopus 로고    scopus 로고
    • Isolation of male germ-line stem cells; influence of GDNF
    • Hofmann M.C., Braydich-Stolle L., Dym M. Isolation of male germ-line stem cells; influence of GDNF. Dev. Biol. 2005, 279:114-124.
    • (2005) Dev. Biol. , vol.279 , pp. 114-124
    • Hofmann, M.C.1    Braydich-Stolle, L.2    Dym, M.3
  • 33
    • 0029101170 scopus 로고
    • YOPRO-1 permits cytofluorometric analysis of programmed cell death (apoptosis) without interfering with cell viability
    • Idziorek T., Estaquier J., De Bels F., Ameisen J.C. YOPRO-1 permits cytofluorometric analysis of programmed cell death (apoptosis) without interfering with cell viability. J. Immunol. Methods 1995, 185:249-258.
    • (1995) J. Immunol. Methods , vol.185 , pp. 249-258
    • Idziorek, T.1    Estaquier, J.2    De Bels, F.3    Ameisen, J.C.4
  • 34
    • 80053434441 scopus 로고    scopus 로고
    • Effects of di(n-butyl) phthalate exposure on foetal rat germ-cell number and differentiation: identification of age-specific windows of vulnerability
    • Jobling M.S., Hutchison G.R., van den Driesche S., Sharpe R.M. Effects of di(n-butyl) phthalate exposure on foetal rat germ-cell number and differentiation: identification of age-specific windows of vulnerability. Int. J. Androl. 2011, 34:e386-e396.
    • (2011) Int. J. Androl. , vol.34
    • Jobling, M.S.1    Hutchison, G.R.2    van den Driesche, S.3    Sharpe, R.M.4
  • 35
    • 33645224455 scopus 로고    scopus 로고
    • Coordinated European investigations of semen quality: results from studies of Scandinavian young men is a matter of concern
    • Jørgensen N., Asklund C., Carlsen E., Skakkebaek N.E. Coordinated European investigations of semen quality: results from studies of Scandinavian young men is a matter of concern. Int. J. Androl. 2006, 29:54-61.
    • (2006) Int. J. Androl. , vol.29 , pp. 54-61
    • Jørgensen, N.1    Asklund, C.2    Carlsen, E.3    Skakkebaek, N.E.4
  • 38
    • 0037108268 scopus 로고    scopus 로고
    • N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation
    • Knoepfler P.S., Cheng P.F., Eisenman R.N. N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev. 2002, 16:2699-2712.
    • (2002) Genes Dev. , vol.16 , pp. 2699-2712
    • Knoepfler, P.S.1    Cheng, P.F.2    Eisenman, R.N.3
  • 39
    • 37549005086 scopus 로고    scopus 로고
    • Why Myc? An unexpected ingredient in the stem cell cocktail
    • Knoepfler P.S. Why Myc? An unexpected ingredient in the stem cell cocktail. Cell Stem Cell 2008, 2:18-21.
    • (2008) Cell Stem Cell , vol.2 , pp. 18-21
    • Knoepfler, P.S.1
  • 41
    • 75749149769 scopus 로고    scopus 로고
    • Comparative toxicological evaluation of phthalate diesters and metabolites in Sprague-Dawley male rats for risk assessment
    • Kwack S.J., Kim K.B., Kim H.S., Lee B.M. Comparative toxicological evaluation of phthalate diesters and metabolites in Sprague-Dawley male rats for risk assessment. J. Toxicol. Environ. Health A 2009, 72:1446-1454.
    • (2009) J. Toxicol. Environ. Health A , vol.72 , pp. 1446-1454
    • Kwack, S.J.1    Kim, K.B.2    Kim, H.S.3    Lee, B.M.4
  • 42
    • 50449108229 scopus 로고    scopus 로고
    • Antagonistic effects of testosterone and the endocrine disruptor mono-(2-ethylhexyl) phthalate on INSL3 transcription in Leydig cells
    • Laguë E., Tremblay J.J. Antagonistic effects of testosterone and the endocrine disruptor mono-(2-ethylhexyl) phthalate on INSL3 transcription in Leydig cells. Endocrinology 2008, 149:4688-4694.
    • (2008) Endocrinology , vol.149 , pp. 4688-4694
    • Laguë, E.1    Tremblay, J.J.2
  • 43
    • 33748755645 scopus 로고    scopus 로고
    • Testicular gene expression profiling following prepubertal rat mono-(2-ethylhexyl) phthalate exposure suggests a common initial genetic response at fetal and prepubertal ages
    • Lahousse S.A., Wallace D.G., Liu D., Gaido K.W., Johnson K.J. Testicular gene expression profiling following prepubertal rat mono-(2-ethylhexyl) phthalate exposure suggests a common initial genetic response at fetal and prepubertal ages. Toxicol. Sci. 2006, 93:369-381.
    • (2006) Toxicol. Sci. , vol.93 , pp. 369-381
    • Lahousse, S.A.1    Wallace, D.G.2    Liu, D.3    Gaido, K.W.4    Johnson, K.J.5
  • 47
    • 0030890609 scopus 로고    scopus 로고
    • The Fas system is a key regulator of germ cell apoptosis in the testis
    • Lee J., Richburg J.H., Younkin S.C., Boekelheide K. The Fas system is a key regulator of germ cell apoptosis in the testis. Endocrinology 1997, 138:2081-2088.
    • (1997) Endocrinology , vol.138 , pp. 2081-2088
    • Lee, J.1    Richburg, J.H.2    Younkin, S.C.3    Boekelheide, K.4
  • 48
    • 0032423198 scopus 로고    scopus 로고
    • Effects of relatively low levels of mono-(2-ethylhexyl) phthalate on cocultured Sertoli cells and gonocytes from neonatal rats
    • Li L.H., Jester W.F., Orth J.M. Effects of relatively low levels of mono-(2-ethylhexyl) phthalate on cocultured Sertoli cells and gonocytes from neonatal rats. Toxicol. Appl. Pharmacol. 1998, 153:258-265.
    • (1998) Toxicol. Appl. Pharmacol. , vol.153 , pp. 258-265
    • Li, L.H.1    Jester, W.F.2    Orth, J.M.3
  • 49
    • 77951588460 scopus 로고    scopus 로고
    • FasL gene-deficient mice display a limited disruption in spermatogenesis and inhibition of mono-(2-ethylhexyl) phthalate-induced germ cell apoptosis
    • Lin Y.C., Yao P.L., Richburg J.H. FasL gene-deficient mice display a limited disruption in spermatogenesis and inhibition of mono-(2-ethylhexyl) phthalate-induced germ cell apoptosis. Toxicol. Sci. 2010, 114:335-345.
    • (2010) Toxicol. Sci. , vol.114 , pp. 335-345
    • Lin, Y.C.1    Yao, P.L.2    Richburg, J.H.3
  • 50
    • 12344267731 scopus 로고    scopus 로고
    • Abnormal Leydig cell aggregation in the fetal testis of rats exposed to di (n-butyl) phthalate and its possible role in testicular dysgenesis
    • Mahood I.K., Hallmark N., McKinnell C., Walker M., Fisher J.S., Sharpe R.M. Abnormal Leydig cell aggregation in the fetal testis of rats exposed to di (n-butyl) phthalate and its possible role in testicular dysgenesis. Endocrinology 2005, 146:613-623.
    • (2005) Endocrinology , vol.146 , pp. 613-623
    • Mahood, I.K.1    Hallmark, N.2    McKinnell, C.3    Walker, M.4    Fisher, J.S.5    Sharpe, R.M.6
  • 52
    • 0035870270 scopus 로고    scopus 로고
    • Promotion of seminomatous tumors by targeted overexpression of glial cell line-derived neurotrophic factor in mouse testis
    • Meng X., de Rooij D.G., Westerdahl K., Saarma M., Sariola H. Promotion of seminomatous tumors by targeted overexpression of glial cell line-derived neurotrophic factor in mouse testis. Cancer Res. 2001, 61:3267-3271.
    • (2001) Cancer Res. , vol.61 , pp. 3267-3271
    • Meng, X.1    de Rooij, D.G.2    Westerdahl, K.3    Saarma, M.4    Sariola, H.5
  • 54
    • 31044436808 scopus 로고    scopus 로고
    • Glial cell-line derived neurotrophic factor-mediated RET signaling regulates spermatogonial stem cell fate
    • Naughton C.K., Jain S., Strickland A.M., Gupta A., Milbrandt J. Glial cell-line derived neurotrophic factor-mediated RET signaling regulates spermatogonial stem cell fate. Biol. Reprod. 2006, 74:314-321.
    • (2006) Biol. Reprod. , vol.74 , pp. 314-321
    • Naughton, C.K.1    Jain, S.2    Strickland, A.M.3    Gupta, A.4    Milbrandt, J.5
  • 55
    • 34548482497 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor regulation of genes essential for self-renewal of mouse spermatogonial stem cells is dependent on Src family kinase signaling
    • Oatley J.M., Avarbock M.R., Brinster R.L. Glial cell line-derived neurotrophic factor regulation of genes essential for self-renewal of mouse spermatogonial stem cells is dependent on Src family kinase signaling. J. Biol. Chem. 2007, 282:25842-25851.
    • (2007) J. Biol. Chem. , vol.282 , pp. 25842-25851
    • Oatley, J.M.1    Avarbock, M.R.2    Brinster, R.L.3
  • 56
    • 17244375059 scopus 로고    scopus 로고
    • Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation
    • Okubo T., Knoepfler P.S., Eisenman R.N., Hogan B.L. Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation. Development 2005, 132:1363-1374.
    • (2005) Development , vol.132 , pp. 1363-1374
    • Okubo, T.1    Knoepfler, P.S.2    Eisenman, R.N.3    Hogan, B.L.4
  • 57
    • 3042759535 scopus 로고    scopus 로고
    • Subcellular distribution of di-(2-ethylhexyl)phthalate in rat testis
    • Ono H., Saito Y., Imai K., Kato M. Subcellular distribution of di-(2-ethylhexyl)phthalate in rat testis. J. Toxicol. Sci. 2004, 29:113-124.
    • (2004) J. Toxicol. Sci. , vol.29 , pp. 113-124
    • Ono, H.1    Saito, Y.2    Imai, K.3    Kato, M.4
  • 58
    • 84862325105 scopus 로고    scopus 로고
    • Mono-(2-ethylhexyl) phthalate increases spermatocyte mitochondrial peroxiredoxin 3 and cyclooxygenase 2
    • Onorato T.M., Brown P.W., Morris P.L. Mono-(2-ethylhexyl) phthalate increases spermatocyte mitochondrial peroxiredoxin 3 and cyclooxygenase 2. J. Androl. 2007, 12:12.
    • (2007) J. Androl. , vol.12 , pp. 12
    • Onorato, T.M.1    Brown, P.W.2    Morris, P.L.3
  • 59
    • 49249087229 scopus 로고    scopus 로고
    • Genes involved in post-transcriptional regulation are overrepresented in stem/progenitor spermatogonia of cryptorchid mouse testes
    • Orwig K.E., Ryu B.Y., Master S.R., Phillips B.T., Mack M., Avarbock M.R., Chodosh L., Brinster R.L. Genes involved in post-transcriptional regulation are overrepresented in stem/progenitor spermatogonia of cryptorchid mouse testes. Stem Cells 2008, 26:927-938.
    • (2008) Stem Cells , vol.26 , pp. 927-938
    • Orwig, K.E.1    Ryu, B.Y.2    Master, S.R.3    Phillips, B.T.4    Mack, M.5    Avarbock, M.R.6    Chodosh, L.7    Brinster, R.L.8
  • 61
    • 0034521058 scopus 로고    scopus 로고
    • The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat
    • Parks L.G., Ostby J.S., Lambright C.R., Abbott B.D., Klinefelter G.R., Barlow N.J., Gray L.E. The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicol. Sci. 2000, 58:339-349.
    • (2000) Toxicol. Sci. , vol.58 , pp. 339-349
    • Parks, L.G.1    Ostby, J.S.2    Lambright, C.R.3    Abbott, B.D.4    Klinefelter, G.R.5    Barlow, N.J.6    Gray, L.E.7
  • 62
    • 0034063586 scopus 로고    scopus 로고
    • Plasticizers in total diet samples, baby food and infant formulae
    • Petersen J.H., Breindahl T. Plasticizers in total diet samples, baby food and infant formulae. Food Addit. Contam. 2000, 17:133-141.
    • (2000) Food Addit. Contam. , vol.17 , pp. 133-141
    • Petersen, J.H.1    Breindahl, T.2
  • 64
    • 0029995352 scopus 로고    scopus 로고
    • Mono-(2-ethylhexyl) phthalate rapidly alters both Sertoli cell vimentin filaments and germ cell apoptosis in young rat testes
    • Richburg J.H., Boekelheide K. Mono-(2-ethylhexyl) phthalate rapidly alters both Sertoli cell vimentin filaments and germ cell apoptosis in young rat testes. Toxicol. Appl. Pharmacol. 1996, 137:42-50.
    • (1996) Toxicol. Appl. Pharmacol. , vol.137 , pp. 42-50
    • Richburg, J.H.1    Boekelheide, K.2
  • 65
    • 0345440129 scopus 로고    scopus 로고
    • Participation of the Fas-signaling system in the initiation of germ cell apoptosis in young rat testes after exposure to mono-(2-ethylhexyl) phthalate
    • Richburg J.H., Nanez A., Gao H. Participation of the Fas-signaling system in the initiation of germ cell apoptosis in young rat testes after exposure to mono-(2-ethylhexyl) phthalate. Toxicol. Appl. Pharmacol. 1999, 160:271-278.
    • (1999) Toxicol. Appl. Pharmacol. , vol.160 , pp. 271-278
    • Richburg, J.H.1    Nanez, A.2    Gao, H.3
  • 66
    • 0038561133 scopus 로고    scopus 로고
    • GDNF-induced seminomatous tumours in mouse - an experimental model for human seminomas?
    • Sariola H., Meng X. GDNF-induced seminomatous tumours in mouse - an experimental model for human seminomas?. APMIS 2003, 111:192-196.
    • (2003) APMIS , vol.111 , pp. 192-196
    • Sariola, H.1    Meng, X.2
  • 67
    • 34848864310 scopus 로고    scopus 로고
    • The missing niche for spermatogonial stem cells: do blood vessels point the way?
    • Shetty G., Meistrich M.L. The missing niche for spermatogonial stem cells: do blood vessels point the way?. Cell Stem Cell 2007, 1:361-363.
    • (2007) Cell Stem Cell , vol.1 , pp. 361-363
    • Shetty, G.1    Meistrich, M.L.2
  • 68
    • 0035194978 scopus 로고    scopus 로고
    • Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate
    • Shultz V.D., Phillips S., Sar M., Foster P.M.D., Gaido K.W. Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate. Toxicol. Sci. 2001, 64:233-242.
    • (2001) Toxicol. Sci. , vol.64 , pp. 233-242
    • Shultz, V.D.1    Phillips, S.2    Sar, M.3    Foster, P.M.D.4    Gaido, K.W.5
  • 69
    • 53249101612 scopus 로고    scopus 로고
    • The novel estrogen receptor, G protein-coupled receptor 30, mediates the proliferative effects induced by 17beta-estradiol on mouse spermatogonial GC-1 cell line
    • Sirianni R., Chimento A., Ruggiero C., De Luca A., Lappano R., Ando S., Maggiolini M., Pezzi V. The novel estrogen receptor, G protein-coupled receptor 30, mediates the proliferative effects induced by 17beta-estradiol on mouse spermatogonial GC-1 cell line. Endocrinology 2008, 149:5043-5051.
    • (2008) Endocrinology , vol.149 , pp. 5043-5051
    • Sirianni, R.1    Chimento, A.2    Ruggiero, C.3    De Luca, A.4    Lappano, R.5    Ando, S.6    Maggiolini, M.7    Pezzi, V.8
  • 70
    • 0035004535 scopus 로고    scopus 로고
    • Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects: opinion
    • Skakkebaek N.E., Rajpert-De Meyts E., Main K.M. Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects: opinion. Hum. Reprod. 2001, 16:972-978.
    • (2001) Hum. Reprod. , vol.16 , pp. 972-978
    • Skakkebaek, N.E.1    Rajpert-De Meyts, E.2    Main, K.M.3
  • 71
    • 0031455688 scopus 로고    scopus 로고
    • Have sperm densities declined? A reanalysis of global trend data
    • Swan S.H., Elkin E.P., Fenster L. Have sperm densities declined? A reanalysis of global trend data. Environ. Health Perspect. 1997, 105:1228-1232.
    • (1997) Environ. Health Perspect. , vol.105 , pp. 1228-1232
    • Swan, S.H.1    Elkin, E.P.2    Fenster, L.3
  • 72
    • 0033724655 scopus 로고    scopus 로고
    • The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996
    • Swan S.H., Elkin E.P., Fenster L. The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996. Environ. Health Perspect. 2000, 108:961-966.
    • (2000) Environ. Health Perspect. , vol.108 , pp. 961-966
    • Swan, S.H.1    Elkin, E.P.2    Fenster, L.3
  • 75
    • 33745453647 scopus 로고    scopus 로고
    • What are the sources of exposure to eight frequently used phthalic acid esters in Europeans?
    • Wormuth M., Scheringer M., Vollenweider M., Hungerbuhler K. What are the sources of exposure to eight frequently used phthalic acid esters in Europeans?. Risk Anal. 2006, 26:803-824.
    • (2006) Risk Anal. , vol.26 , pp. 803-824
    • Wormuth, M.1    Scheringer, M.2    Vollenweider, M.3    Hungerbuhler, K.4
  • 76
    • 84872955984 scopus 로고    scopus 로고
    • Germline stem cell niches
    • Harvard Stem Cell Institute, Cambridge, MA, L. Girard (Ed.)
    • Xie T. Germline stem cell niches. StemBook (Internet) 2008, Harvard Stem Cell Institute, Cambridge, MA. L. Girard (Ed.).
    • (2008) StemBook (Internet)
    • Xie, T.1
  • 77
    • 77953085869 scopus 로고    scopus 로고
    • Mono-(2-ethylhexyl) phthalate-induced disruption of junctional complexes in the seminiferous epithelium of the rodent testis is mediated by MMP2
    • Yao P.-L., Lin Y.-C., Richburg J.H. Mono-(2-ethylhexyl) phthalate-induced disruption of junctional complexes in the seminiferous epithelium of the rodent testis is mediated by MMP2. Biol. Reprod. 2010, 82:516-527.
    • (2010) Biol. Reprod. , vol.82 , pp. 516-527
    • Yao, P.-L.1    Lin, Y.-C.2    Richburg, J.H.3
  • 78
    • 34247131767 scopus 로고    scopus 로고
    • Transcriptional regulation of FasL expression and participation of sTNF-alpha in response to sertoli cell injury
    • Yao P.L., Lin Y.C., Sawhney P., Richburg J.H. Transcriptional regulation of FasL expression and participation of sTNF-alpha in response to sertoli cell injury. J. Biol. Chem. 2007, 282:5420-5431.
    • (2007) J. Biol. Chem. , vol.282 , pp. 5420-5431
    • Yao, P.L.1    Lin, Y.C.2    Sawhney, P.3    Richburg, J.H.4
  • 79
    • 0041632103 scopus 로고    scopus 로고
    • Induction of apoptosis by mono(2-ethylhexyl)phthalate (MEHP) in U937 cells
    • Yokoyama Y., Okubo T., Kano I., Sato S., Kano K. Induction of apoptosis by mono(2-ethylhexyl)phthalate (MEHP) in U937 cells. Toxicol. Lett. 2003, 15(144):371-381.
    • (2003) Toxicol. Lett. , vol.15 , Issue.144 , pp. 371-381
    • Yokoyama, Y.1    Okubo, T.2    Kano, I.3    Sato, S.4    Kano, K.5
  • 80
    • 34548856483 scopus 로고    scopus 로고
    • Differential expression of peroxiredoxin 6 in fetal rat testis following in utero exposure to di(n-butyl) phthalate
    • Zhang W., Shen H., Ma L., Shen B., Xu Z., Wang X. Differential expression of peroxiredoxin 6 in fetal rat testis following in utero exposure to di(n-butyl) phthalate. Toxicology 2007, 240:86-95.
    • (2007) Toxicology , vol.240 , pp. 86-95
    • Zhang, W.1    Shen, H.2    Ma, L.3    Shen, B.4    Xu, Z.5    Wang, X.6


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