Mono-(2-ethylhexyl) phthalate-induced disruption of junctional complexes in the seminiferous epithelium of the rodent testis is mediated by MMP2

Biology of Reproduction

Volumn 82, Issue 3, 2010, Pages 516-527

  Yao, Pei Li ^a   Lin, Yi Chen ^a   Richburg, John H ^a  

^a The Center for Molecular Carcinogenesis and Toxicology   (United States)

Author keywords

Apoptosis; Blood testis barrier; Ectoplasmic specialization; Germ cell; Junction; MEHP; MMP2; Paracrine signaling; Sertoli cells; Signal transduction; Testis

Indexed keywords

BETA1 INTEGRIN; GELATINASE A; GELATINASE INHIBITOR; LAMININ; LAMININ GAMMA3; OCCLUDIN; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; SB 3CT; TISSUE INHIBITOR OF METALLOPROTEINASE 2; UNCLASSIFIED DRUG; DRUG DERIVATIVE; MONO (2 ETHYLHEXYL)PHTHALATE; MONO-(2-ETHYLHEXYL)PHTHALATE; MULTIPROTEIN COMPLEX; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD TESTIS BARRIER; CELL DISRUPTION; CELL LOSS; CONTROLLED STUDY; ENZYME ACTIVATION; GERM CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SEMINIFEROUS TUBULE EPITHELIUM; SERTOLI CELL; TESTIS INJURY; TIGHT JUNCTION; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; C57BL MOUSE; CELL ADHESION; CELL CULTURE; CELL JUNCTION; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; FISCHER 344 RAT; METABOLISM; PHYSIOLOGY; TESTIS; TESTIS DISEASE; ULTRASTRUCTURE;

MUS; RODENTIA;

ADHERENS JUNCTIONS; ANIMALS; BLOOD-TESTIS BARRIER; CELL ADHESION; CELLS, CULTURED; DIETHYLHEXYL PHTHALATE; ENZYME ACTIVATION; MALE; MATRIX METALLOPROTEINASE 2; MICE; MICE, INBRED C57BL; MULTIPROTEIN COMPLEXES; RATS; RATS, INBRED F344; SEMINIFEROUS EPITHELIUM; TESTICULAR DISEASES; TESTIS;

EID: 77953085869     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.109.080374     Document Type: Article

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