Assessing the relevance of in vitro measures of phthalate inhibition of steroidogenesis for in vivo response

Toxicology in Vitro

Volumn 24, Issue 1, 2010, Pages 327-334

  Clewell, Rebecca A ^a,b   Campbell, Jerry L ^b   Ross, Susan M ^b   Gaido, Kevin W ^b   Clewell III, Harvey J ^b   Andersen, Melvin E ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

Author keywords

Developmental toxicity; Fetal rat; Phthalates; Testes; Testosterone inhibition

Indexed keywords

PHTHALIC ACID; PHTHALIC ACID BUTYL ESTER; PHTHALIC ACID ESTER; PHTHALIC ACID ETHYL ESTER; PHTHALIC ACID MONO N OCTYL ESTER; PHTHALIC ACID MONOBENZYL ESTER; PHTHALIC ACID MONOHEXYL ESTER; PHTHALIC ACID MONOMETHYL ESTER; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ASSAY; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DOWN REGULATION; FEMALE; FETUS; HORMONE INHIBITION; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEXUAL DEVELOPMENT; TESTIS; TESTOSTERONE SYNTHESIS; TOXICITY TESTING;

ANIMALS; CELL SURVIVAL; DOWN-REGULATION; FEMALE; FETAL DEVELOPMENT; FETUS; LEYDIG CELLS; LUTEINIZING HORMONE; MALE; MICE; PHTHALIC ACIDS; PREGNANCY; PROGESTERONE; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK ASSESSMENT; SEXUAL MATURATION; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP; TESTIS; TESTOSTERONE;

RATTUS;

EID: 72049112300     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.08.003     Document Type: Article

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