The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation

Journal of Experimental Medicine

Volumn 204, Issue 5, 2007, Pages 1131-1144

  McCarthy, Corinna ^a   Shepherd, Dawn ^a   Fleire, Sebastian ^d   Stronge, Victoria S ^a   Koch, Michael ^b   Illarionov, Petr A ^e   Bossi, Giovanna ^c   Salio, Mariolina ^a   Denkberg, Galit ^f   Reddington, Faye ^e   Tarlton, Andrea ^a   Reddy, B Gopal ^g   Schmidt, Richard R ^g   Reiter, Yoram ^f   Griffiths, Gillian M ^c   Van Der Merwe, P Anton ^c   Besra, Gurdyal S ^e   Jones, E Yvonne ^b   Batista, Facundo D ^d   Cerundolo, Vincenzo ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^e UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^f TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^g UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD1D ANTIGEN; GALACTOSYLCERAMIDE; LIPID;

ARTICLE; BINDING AFFINITY; CELL ACTIVATION; CONFORMATIONAL TRANSITION; HUMAN; HUMAN CELL; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; SYNAPSE;

ANTIGENS, CD1; CALCIUM; CELL LINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; GALACTOSYLCERAMIDES; GLYCOLIPIDS; HUMANS; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; RECEPTORS, ANTIGEN, T-CELL;

EID: 34249054887     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20062342     Document Type: Article

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