Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy

Journal of Neurochemistry

Volumn 117, Issue 5, 2011, Pages 824-832

  Leke, Renata ^a,b   Bak, Lasse K ^b   Iversen, Peter ^c   Sãrensen, Michael ^c   Keiding, Susanne ^c   Vilstrup, Hendrik ^c   Ott, Peter ^c   Portela, Luis V ^a   Schousboe, Arne ^b   Waagepetersen, Helle S ^b  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

cirrhosis; GABA synthesis; glutamine; hepatic encephalopathy; TCA cycle

Indexed keywords

4 AMINOBUTYRIC ACID; AMMONIA; ASPARTIC ACID; GLUTAMIC ACID; GLUTAMINE;

AMINO ACID METABOLISM; AMINO ACID SYNTHESIS; AMMONIA BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN METABOLISM; CITRIC ACID CYCLE; FEMALE; GABAERGIC TRANSMISSION; HEPATIC ENCEPHALOPATHY; LIVER CIRRHOSIS; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETATES; AMMONIA; ANIMALS; ASTROCYTES; BRAIN CHEMISTRY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHRONIC DISEASE; CITRIC ACID CYCLE; COCULTURE TECHNIQUES; COMMON BILE DUCT; EXCITATORY AMINO ACIDS; FEMALE; GAMMA-AMINOBUTYRIC ACID; HEPATIC ENCEPHALOPATHY; LIGATION; LIVER CIRRHOSIS; MASS SPECTROMETRY; MICE; NEURONS; NEUROTRANSMITTER AGENTS; RATS; RATS, WISTAR;

RATTUS;

EID: 79955660794     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07244.x     Document Type: Article

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