Selective inhibition of T cell proliferation but not expression of effector function by human alveolar macrophages

Thorax

Volumn 52, Issue 9, 1997, Pages 786-795

  Upham, John W ^a   Strickland, Deborah H ^a   Robinson, Bruce W S ^b   Holt, Patrick G ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Alveolar macrophage; Immune regulation; T cell

Indexed keywords

CYTOKINE; HOUSE DUST ALLERGEN; PHYTOHEMAGGLUTININ;

ARTICLE; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; LUNG ALVEOLUS MACROPHAGE; MONONUCLEAR CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

EID: 0030765861     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.52.9.786     Document Type: Article

References (39)

1. Holt PG. Regulation of antigen presenting cell (s) in lung and airway tissues. Eur Respir J 1993;6:120-9.
2. Warner LA, Holt PG, Mayrhofer G. Alveolar macrophages. VI. Regulation of alveolar macrophage-mediated suppression of lymphocyte proliferation by a putative T cell. Immunology 1981;42:137-47.
3. McCombs CC, Michalski JP, Westerfield BT, Light RW. Human alveolar macrophages suppress the proliferative response to peripheral blood lymphocytes. Chest 1982;82: 266-71.
4. Toews GB, Vial WC, Dunn MM, Guzzetta P, Nunez G, Stastny P, et al. The accessory cell function of human alveolar macrophages in specific T cell proliferation. J Immunol 1984;132:181-6.
5. Ettensohn DB, Lalor PA, Roberts Jr NJ. Human alveolar macrophage regulation of lymphocyte proliferation. Am Rev Respir Dis 1986;133:1091-6.
6. Rich EA, Cooper C, Toosii Z, et al. Requirement for cell-to-cell contact for the immunosuppressive activity of human alveolar macrophages. Am J Respir Cell Mol Biol 1991;4: 287-94.
7. Schauble TL, Boom WH, Finegan CK, Rich EA. Characterization of suppressor function of human alveolar macrophages for T lymphocyte responses to phytohemagglutinin: cellular selectivity, reversibility, and early events in T cell activation. Am J Respir Cell Mol Biol 1993; 8:89-97.
8. Thepen T, McMenamin C, Girn B, Kraal G, Holt PG. Regulation of IgE production in pre-sensitized animals: in vivo elimination of alveolar macrophages preferentially increases IgE responses to inhaled allergen. Clin Exp Allergy 1992;22:1107-14.
9. Thepen T, Hoeben K, Breve J, Kraal G. Alveolar macrophages down-regulate local pulmonary immune responses against intratracheally administered T cell dependent, but not T cell-independent antigens. Immunology 199;76: 60-4.
10. Kawabe T, Isobe KI, Hasegawa Y, Nakashima I, Shimokata K. Immunosuppressive activity induced by nitric oxide in culture supernatant of activated rat alveolar macrophages. Immunology 1992;76:72-8.
11. Yarbrough WJ, Wilkes DS, Weissler JC. Human alveolar macrophages inhibit receptor mediated increases in intracellular calcium concentration in lymphocytes. Am J Respir Cell Mol Biol 1991;5:411-5.
12. Davidson BL, Faust J, Pessano S, Daniele RP, Rovera G. Differentiation and activation phenotypes of lung T lymphocytes differ from those of circulating T lymphocytes. J Clin Invest 1985;76:60-5.
13. Marathias KP, Preffer FI, Pinto C, Kradin RL. Most human pulmonary infiltrating lymphocytes display the surface immune phenotype and functional responses of sensitized T cells. Am J Respir Cell Mol Biol 1991;5:470-6.
14. Robinson DS, Hamid Q, Ying S, Tsicopoulos A, Barkans J, Bentley AM, et al. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992;326:298-304.
15. Krishnaswamy G, Liu MC, Su S-N, et al. Analysis of cytokine transcripts in the bronchoalveolar lavage cells of patients with asthma. Am J Respir Cell Mol Biol 1993;9: 279-86.
16. Garlepp MJ, Rose AH, Bowman RV, Mavaddat N, Dench J, Holt BJ, et al. A clonal analysis of lung T cells derived by bronchoalveolar lavage of healthy individuals. Immunology 1992;77:31-7.
17. Ferro TJ, Kern JA, Elias JA, Kamoun M, Daniele RP, Rossman MD. Alveolar macrophages, blood monocytes and density fractionated alveolar macrophages differ in their ability to promote lymphocyte proliferation to mitogen and antigen. Am Rev Respir Dis 1987;135:682-7.
18. Upham JW, Holt BJ, Baron-Hay MJ, Yabuhara A, Hales BJ, Thomas WR, et al. Inhalant allergen-specific T cell reactivity is detectable in close to 100% of atopic and normal individuals: covert responses are unmasked by serum-free medium. Clin Exp Allergy 1995;25:634-42.
19. Chelen CJ, Fang Y, Freeman GJ, Secrist H, Marshall JD, Hwang PT, et al. Human alveolar macrophages present antigen ineffectively due to defective expression of B7 costimulatory cell surface molecules. J Clin Invest 1995; 95:1415-21.
20. Rabinovitch PS, June CH, Grossman A, Ledbetter JA. Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of Indo-1 and immunofluorescence with flow cytometry. J Immunol 1986;137: 952-61.
21. Upham JW, McMenamin C, Schon-Hegrad MA, Robinson BWS, Holt PG. Functional analysis of human bronchial mucosal T cells extracted with interleukin-2. Am J Respir Crit Care Med 1994;149:1608-13.
22. Moore SA, Stricter RM, Rolfe MW, Standiford TJ, Burdick MD, Kunkel SL. Expression and regulation of human alveolar macrophage-derived interleukin-1 receptor antagonist. Am J Respir Cell Mol Biol 1992;6:569-75.
23. Roth MD, Golub SH. Human pulmonary macrophages utilize prostaglandins and transforming growth factor beta 1 to suppress lymphocyte activation. J Leukoc Biol 1993; 53:366-71.
24. Holt PG. Alveolar macrophages. III. Studies on the mechanisms of inhibition of T cell proliferation. Immunology 1979;37:437-45.
25. Gelfand EW, Cheung RK, Grinstein S, Mills GB. Characterization of the role for calcium influx in mitogen-induced triggering of human T cells. Identification of calcium-dependent and calcium-independent signals. Eur J Immunol 1986;16:907-12.
26. Cantrell DA, Verbi W, Davies A, Parker P, Crumpton MJ. Evidence that protein kinase C differentially regulates the human T lymphocyte CD2 and CD3 surface antigens. Eur J Immunol 1988;1391-6.
27. Springer TA. A birth certificate for CD2. Nature 1991;353: 704-5.
28. June CH, Ledbetter JA, Linsley PS, Thompson CB. Role of the CD28 receptor in T cell activation. Immunol Today 1990;11:211-6.
29. Upham JW, Strickland DH, Bilyk N, Robinson BWS, Holt PG. Alveolar macrophages from humans and rodents selectively inhibit T-cell proliferation but permit T-cell activation and cytokine secretion. Immunology 1995;84: 142-7.
30. Taniguchi T, Minami Y. The IL-2/IL-2 receptor system: a current overview. Cell 1993;73:5-8.
31. Pennline KJ, Herscowitz HB. Dual role for alveolar macrophages in humoral and cell-mediated immune responses: evidence for suppressor and enhancing functions. J Reticuloend Soc 1981;30:205-17.
32. Holt PG, Oliver J, Bilyk N, McMenamin C, McMenamin PG, Kraal G, et al. Downregulation of the antigen presentation function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages. J Exp Med 1993;177: 397-407.
33. Haskill S, Johnson C, Eierman D, Becker S, Warren K. Adherence induces selective mRNA expression of monocyte mediators and proto-oncogenes. J Immunol 1988; 140:1690-4.
34. Strickland D, Kees UR, Holt PG. Regulation of T cell activation in the lung: alveolar macrophages induce reversible T cell anergy in vitro associated with inhibition of interleukin-2 receptor signal transduction. Immunology 1996;87:250-8.
35. Wilkes DS, Weissler JC. Alloantigen-induced immunoglobulin production in human lung: differential effects of accessory cell populations on IgE synthesis. Am J Respir Cell Mol Biol 1994;10:339-46.
36. Yarbrough WJ, Wilkes DS, Weissler JC. Inhibition of lymphokine-activated killer cells by human pulmonary macrophages: discordance between up-regulation of the beta chain (p75) of the interleukin-2 receptor on CD56 + cells and limited response to interleukin-2. Am J Respir Cell Mol Biol 1994;10:184-91.
37. Wilsher ML, Hughes DA, Haslam PL. Immunoregulatory properties of pulmonary surfactant: effect of lung lining fluid on proliferation of human blood lymphocytes. Thorax 1988;43:354-9.
38. Paine III R, Mody CH, Chavis A, Spahr MA, Turka LA, Toews GB. Alveolar epithelial cells block lymphocyte proliferation in vitro without inhibiting activation. Am J Respir Cell Mol Biol 1991;5:221-9.
39. Poulter LW, Janossy G, Power C, Sreenan S, Burke C. Immunological/physiological relationships in asthma: potential regulation by lung macrophages. Immunol Today 1994;15:258-61.